伤口世界
- 星期三, 12 1月 2022
Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches
Abstract: Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by difffferent degrees of severity. Wound healing is a complex process that involves multiple steps such as inflflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plantbased treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.
Keywords: wound healing; pentacyclic triterpenes; tetracyclic triterpenes
- 星期二, 11 1月 2022
The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model
Abstract: Mangifera indica can generate up to 60% of polluting by-products, including peels. However,it has been shown that flflavonoids and mangiferin are mainly responsible for the antioxidant, antiinflflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was analyzed by HPLC-DAD, as well as concentrations of total phenol (TPC) and flflavonoids (TFC) and antioxidant activity (SA50). Wound healing effificacy was determined by measurements of wound contraction, histological analysis, and tensiometric method; moreover, anti-inflflammatory, antibacterial, and acute dermal toxicity (OECD 402) were also evaluated. Phenol, resorcinol, conjugated resorcinol, and mangiferin were detected. TPC, TFC, and SA50 were 136 mg GAE/g, 101.66 mg QE/g, and 36.33 µg/mL, respectively. Tensile strength and wound contraction closure did not show signifificant differences between MEMI and dexpanthenol groups. Histological analysis (after 14 days) shows a similar architecture between MEMI treatment and normal skin. MEMI exhibits a reduction in edema. Staphylococcus epidermidis had an MIC of 2 mg/mL, while Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli reached 4 mg/mL. The MEMI showed no signs of toxicity. Therefore, this study demonstrates multiple targets that flflavonoids and mangiferin of MEMI may present during the healing process.
Keywords: Mangifera indica peel; wound healing; antibacterial; antioxidant.
- 星期一, 10 1月 2022
Role of Honey in Advanced Wound Care
Abstract: Honey is a natural product rich in several phenolic compounds, enzymes, and sugars with antioxidant, anticarcinogenic, anti-inflflammatory, and antimicrobial potential. Indeed, the development of honey-based adhesives for wound care and other biomedical applications are topics being widely investigated over the years. Some of the advantages of the use of honey for wound-healing solutions are the acceleration of dermal repair and epithelialization, angiogenesis promotion, immune response promotion and the reduction in healing-related infections with pathogenic microorganisms. This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can inflfluence the healing properties, also highlighting promising results in in vitro and in vivo trials. The challenges in the use of honey for wound healing are also covered and discussed. The delivery methodology (direct application, incorporated in fifibrous membranes and hydrogels) is also presented and discussed.
Keywords: honey; wound-healing; antioxidant; antimicrobial; hydrogels; dermal repair; hydrogel
- 星期一, 10 1月 2022
Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review
Abstract: Epigallocatechin gallate (EGCG) is associated with various health benefifits. In this review, we searched current work about the effects of EGCG and its wound dressings on skin for wound healing. Hydrogels, nanoparticles, micro/nanofifiber networks and microneedles are the major types of EGCG-containing wound dressings. The benefificial effects of EGCG and its wound dressings at different stages of skin wound healing (hemostasis, inflflammation, proliferation and tissue remodeling) were summarized based on the underlying mechanisms of antioxidant, anti-inflflammatory,antimicrobial, angiogenesis and antififibrotic properties. This review expatiates on the rationale of using EGCG to promote skin wound healing and prevent scar formation, which provides a future clinical application direction of EGCG.
Keywords: EGCG; skin wound healing; wound dressing; anti-inflammation; angiogenesis; antifibrosis.
- 星期五, 07 1月 2022
Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process
Abstract: Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and fifinally culminating with the formation of a fifibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflflammation and immune suppression at the wound site represents a medical challenge. So far, many therapeutic strategies have been developed to improve cellular homeostasis and chronic wounds in order to accelerate wound repair. In this context, the role of Nuclear factor erythroid 2-related factor 2 (Nrf2) during the wound healing process has been a stimulating research topic for therapeutic perspectives. Nrf2 is the main regulator of intracellular redox homeostasis. It increases cytoprotective gene expression and the antioxidant capacity of mammalian cells. It has been reported that some bioactive compounds attenuate cellular stress and thus accelerate cell proliferation, neovascularization and repair of damaged tissues by promoting Nrf2 activation. This review highlights the importance of the Nrf2 signaling pathway in wound healing strategies and the role of bioactive compounds that support wound repair through the modulation of this crucial transcription factor.
Keywords: Nrf2; wound healing; skin; inflflammation; antioxidant.
- 星期五, 07 1月 2022
次氯酸在伤口护理中的应用研究进展
摘要 介绍了次氯酸溶液的发展史、杀菌机制、特点、与其他伤口清洁消毒剂的比较、使用方法以及当前研究的不足，旨在为次氯酸溶液在伤口治疗、护理中的应用提供依据。
关键词 次氯酸溶液；伤口；感染；细菌生物膜；临床应用；综述
