名医介绍

王爱红

博士、主任医师、硕士研究生导师

战略支援部队特色医学中心(原解放军第306医院)内分泌科主任

中华糖尿病杂志通讯编委，中华健康管理学杂志，中国全科医学审稿人

TranslationalSurgery 青年编委，Diabetes Care 中文版青年编委

专业特长:从事糖尿病及其慢性并发症的临床及科研工作，尤其是糖尿病足及下肢动脉病变方面，发表论文70余篇，获军队医疗成果二等整2项，军队医疗成果三等奖3项，承担全军高新技术课题，全军青年培育-拔尖项目及首都特色应用研究课题等

汤正义

博士、主任医师

上海交通大学医学院附属瑞金医院内分泌代谢病科主任医师

兼任中华医学会糖尿病分会神经病变，糖尿病足溃疡与大血管病变学组成员

中华医学会上海糖尿病分会委员与糖尿病足病学组组长

拍仟《中国辣尿病杂志》等国内多个医学杂志的编季

长期从事临床疾病的诊治与研究，先后在甲状腺相关眼病，糖尿病与相关并发症垂体，督上晚方面做了一系列的临床和基础研究，相应的文音先后发表了100多篇，句括SC收录30余篇，与多部专芙的编写，还在临床上建寸这些疾病一系列的诊断和治疗特色方法。目前专注于糖尿病神经病变与糖尿。

王爱萍

主任医师

东部战区空军医院糖尿病足中心主任

2019年南京市十佳医生

中华医学会糖尿病分会足病与周围血管病变学组副组长

江苏省医学会糖尿病分会足病与周围血管病变学组组长

主要从事慢性伤口，尤其是糖尿病足伤口的临床和基础研究工作:

获得省级重大和重点课题各1项

国家自然基金面上项目1项

已发夷论文40余篇其中SC收灵18篇

王爱萍获得省级以上科技进步奖2项

创新奖1项主编出版书籍2本(其中1本为国家重点图书的第二册)

主笔撰写了双语版的《多学科合作下的糖尿病足诊治实践指南(2020版)》

陈轶坚

博士，副主任医师，硕士研究生导师

复日大学附属华山医院抗生素研究所临床应用室副主任

中华医学会细菌感染与耐药防治分会工作秘书、青年学组副组长

中国医药教育协会感染专业委员会青年委员

上海市医学会感染与化疗分会青年委员会副主任委员

瑞典Karolinska(卡罗琳斯卡)医学院访问学者

专长于各种细菌性和真菌性疾病的诊治，及发热待查的诊断熟悉各种抗感染药物的~1V期新药临床研究以第一作者或通讯作者发表文竟20余篇

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K2 Content

Cutting-edge skin ageing research on tissue stem cell 2024-12-23 00:00

Received December 11, 2023; accepted February 20, 2024; published online February 26, 2024

Ryo Ichijo∗

Laboratory of Tissue Homeostasis, Department of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University, 53 Shogoin

Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

∗Ryo Ichijo, Laboratory of Tissue Homeostasis, Department of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan. Tel.: +81-75-751-4016,

email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

In developed economies, the growing number of older individuals is a pressing issue. As a result, research progress into ageing has emphasized the significance of staying healthy in one’s later years. Stem cells have a fundamental role to play in fostering diverse cell types and necessary processes for tissue repair and regeneration. Stem cells experience the effects of ageing over time, which is caused by their functional deterioration. Changes to stem cells, their niches and signals from other tissues they interact with are crucial factors in the ageing of stem cells. Progress in single-cell RNA sequencing (scRNA-seq) technology has greatly advanced stem cell research. This review examines the mechanisms of stem cell ageing, its impact on health and investigates the potential of stem cell therapy, with a special emphasis on the skin.

Graphical Abstract

Keywords: ageing, homeostasis, regeneration, single cell RNA sequencing, stem cell.
Characterization of skin barrier defects using infrared spectroscopy in patients with atopic dermatitis 2024-12-20 00:00
Samuel F. Williams , 1 Helen Wan,1 John Chittock , 1 Kirsty Brown,1 Andrew Wigley,1 Michael J. Cork 1,2,3 and Simon G. Danby 1

1 Sheffield Dermatology Research, Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Sheffield, UK

2 Sheffield Children’s NHS Foundation Trust, Sheffield Children’s Hospital, Western Bank, Sheffield, UK

3 Sheffield Teaching Hospitals NHS Foundation Trust, The Royal Hallamshire Hospital, Sheffield, UK Correspondence: Samuel F. Williams. Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background Atopic dermatitis (AD) is characterized by skin barrier defects that are often measured by biophysical tools that observe the functional properties of the stratum corneum (SC).

Objectives To employ in vivo infrared spectroscopy alongside biophysical measurements to analyse changes in the chemical composition of the SC in relation to AD severity.

Methods We conducted an observational cross-sectional cohort study where attenuated total reflection Fourier transform infrared (ATRFTIR) spectroscopy measurements were collected on the forearm alongside surface pH, capacitance, erythema and transepidermal water loss (TEWL), combined with tape stripping, in a cohort of 75 participants (55 patients with AD stratified by phenotypic severity and 20 healthy controls). Common FLG variant alleles were genotyped.

Results Reduced hydration, elevated TEWL and redness were all associated with greater AD severity. Spectral analysis showed a reduction in 1465 cm–1 (full width half maximum) and 1340 cm–1 peak areas, indicative of less orthorhombic lipid ordering and reduced carboxylate functional groups, which correlated with clinical severity (lipid structure r=–0.59, carboxylate peak area r=–0.50).

Conclusions ATR-FTIR spectroscopy is a suitable tool for the characterization of structural skin barrier defects in AD and has potential as a clinical tool for directing individual treatment based on chemical structural deficiencies.

What is already known about this topic?
- The skin of patients with atopic dermatitis (AD) is characterized by atypical lipid levels and structure, diminished natural moisturizing factor (NMF) and filaggrin deficiency.
- As a result of these structural alterations, normal skin barrier function is reduced.
- Purpose-built probes or assays are typically used to monitor and quantify biochemical changes, such as pH, moisturization factors, hydration and transepidermal water loss (TEWL), on the epidermal surface as a result of the onset of dermatitis.
What does this study add?
- Characteristics from the mid-infrared spectra collected from participants’ skin provided molecular insight into the pathogenesis of AD.
- Lipid- and carboxylate-associated mid-infrared peaks were strongly associated with biophysical measurements, including skin hydration, NMF and TEWL.
- Peaks analysis also indicated a filaggrin deficiency, caused by genetic deposition or inflammatory action.
- Early detection of a genetic predisposition to AD would allow for preventative measures to be undertaken.
Accepted: 20 November 2023

© The Author(s) 2023. Published by Oxford University Press on behalf of British Association of Dermatologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Changes in human skin composition due to intrinsic aging: a histologic and morphometric study 2024-12-19 00:00

Marta Arnal‑Forné1 · Tamara Molina‑García2 · María Ortega2 · Víctor Marcos‑Garcés2,3 · Pilar Molina4 · Antonio Ferrández‑Izquierdo1,2,5 · Pilar Sepulveda1,6,7 · Vicente Bodí2,3,6,8 · César Ríos‑Navarro1,2,6 · Amparo Ruiz‑Saurí1,2,6

Accepted: 10 June 2024 / Published online: 2 July 2024

© The Author(s) 2024

Abstract

Skin represents the main barrier against the external environment, but also plays a role in human relations, as one of the prime determinants of beauty, resulting in a high consumer demand for skincare-related pharmaceutical products. Given the importance of skin aging in both medical and social spheres, the present research aims to characterize microscopic changes in human skin composition due to intrinsic aging (as opposed to aging infuenced by external factors) via histological analysis of a photoprotected body region. Samples from 25 autopsies were taken from the periumbilical area and classifed into four age groups: group 1 (0–12 years), group 2 (13–25 years), group 3 (26–54 years), and group 4 (≥55 years). Diferent traditional histological (hematoxylin–eosin, Masson’s trichrome, orcein, toluidine, Alcian blue, and Feulgen reaction) and immunohistochemical (CK20, CD1a, Ki67, and CD31) stains were performed. A total of 1879 images photographed with a Leica DM3000 optical microscope were morphometrically analyzed using Image ProPlus 7.0 for further statistical analysis with GraphPad 9.0. Our results showed a reduction in epidermis thickness, interdigitation and mitotic indexes, while melanocyte count was raised. Papillary but not reticular dermis showed increased thickness with aging. Specifcally, in the papillary layer mast cells and glycosaminoglycans were expanded, whereas the reticular dermis displayed a diminution in glycosaminoglycans and elastic fbers. Moreover, total cellularity and vascularization of both dermises were diminished with aging. This morphometric analysis of photoprotected areas reveals that intrinsic aging signifcantly infuences human skin composition. This study paves the way for further research into the molecular basis underpinning these alterations, and into potential antiaging strategies.

Keywords Skin aging · Intrinsic aging · Morphometric analysis · Human biopsies

César Ríos-Navarro 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Amparo Ruiz-Saurí 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Pathology, University of Valencia, Avda. Blasco Ibáñez 15. 46010, Valencia, Spain

2 Instituto de Investigación Sanitaria INCLIVA Biomedical Research Institute, Avda. Menéndez Pelayo 4acc, 46010 Valencia, Spain

3 Cardiology Department, Hospital Clínico Universitario, Valencia, Spain

4 Department of Pathology, Instituto de Medicina Legal y Ciencias Forenses, Valencia, Spain

5 Anatomic Pathology Department, Hospital Clínico Universitario, Valencia, Spain

6 Centro de Investigación Biomédica en Red (CIBER)-CV, Madrid, Spain

7 Regenerative Medicine and Heart Transplantation Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain

8 Department of Medicine, University of Valencia, Valencia, Spain

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

王爱红

汤正义

王爱萍

陈轶坚

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

王爱红

汤正义

王爱萍

陈轶坚

消息订阅

学术会议

伤口世界提示