Costanza Rossi1, *, Sabrina Vaccaro1, *, Massimiliano Borselli1 , Giovanna Carnovale Scalzo1 , Mario Damiano Toro2, Vincenzo Scorcia1 , Giuseppe Giannaccare 31

Department of Ophthalmology, University Magna Graecia of Catanzaro, Catanzaro, Italy; 2 Eye Clinic, Public Health Department, University of Naples

Federico II, Naples, Italy; 3 Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy

*These authors contributed equally to this work

Correspondence: Giuseppe Giannaccare, Ophthalmology, Chairman of Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy, Email 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Purpose: To report the outcomes of a novel microwave heating device (Blepha EyeBag®) used serially for the treatment of meibomian gland dysfunction (MGD).

Patients and Methods: This prospective single center study was conducted at University Magna Graecia of Catanzaro. Patients were instructed to apply the compress twice daily for 15 days and once per day every two days, as reported in the package insert. Outcome measures were i) ocular surface disease index (OSDI) score, ii) tear meniscus height (TMH), iii) non-invasive keratograph break-up time (NIKBUT) (first and average), iv) meiboscore, v) bulbar redness. Evaluations were performed at baseline (T0) after 15 days (T1) and after 45 days of therapy (T2).

Results: Overall, 19 patients with MGD (8 males, 11 females; mean age 64.58 ± 9.72 years) were included. The mean value of OSDI score showed a significant decrease from 28.16 ± 17.46 at T0 to 13.69 ± 7.62 at T2 (p=0.008). The mean value of NIKBUT first significantly increased from 6.67 ± 3.51 seconds (s) at T0 to 10.46 ± 4.64 at T2 (p=0.0121); in parallel, the mean value of NIKBUT average increased significantly from 11.09 ± 4.15 s at T0 to 14.95 ± 4.85 at T2 (p=0.0049). No significant differences were detected at each time point for bulbar redness, meiboscore and TMH. Throughout the entire study, no adverse events were recorded.

Conclusion: The microwave-heated eye bag treatment is both safe and effective for treatment of MGD, being able to significantly ameliorate both patient-reported symptoms and tear film stability.

Keywords: MGD, dry eye, ocular surface disease, warming device, eyelid

Angelica Dessì, Roberta Pintus, Vassilios Fanos and Alice Bosco *

Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, AOU Cagliari, 09124 Cagliari, Italy; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.D.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (V.F.) * Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Citation: Dessì, A.; Pintus, R.; Fanos, V.; Bosco, A. Integrative Multiomics Approach to Skin: The Sinergy between Individualised Medicine and Futuristic Precision Skin Care?

Metabolites 2024, 14, 157. https:// doi.org/10.3390/metabo14030157

Academic Editors: Eleftherios Panteris and Olga Deda

Received: 1 February 2024

Revised: 1 March 2024

Accepted: 4 March 2024

Published: 7 March 2024

Abstract: The skin is a complex ecosystem colonized by millions of microorganisms, the skin microbiota, which are crucial in regulating not only the physiological functions of the skin but also the metabolic changes underlying the onset of skin diseases. The high microbial colonization together with a low diversity at the phylum level and a high diversity at the species level of the skin is very similar to that of the gastrointestinal tract. Moreover, there is an important communication pathway along the gut–brain–skin axis, especially associated with the modulation of neurotransmitters by the microbiota. Therefore, it is evident that the high complexity of the skin system, due not only to the genetics of the host but also to the interaction of the host with resident microbes and between microbe and microbe, requires a multi-omics approach to be deeply understood. Therefore, an integrated analysis, with high-throughput technologies, of the consequences of microbial interaction with the host through the study of gene expression (genomics and metagenomics), transcription (transcriptomics and meta-transcriptomics), and protein production (proteomics and meta-proteomics) and metabolite formation (metabolomics and lipidomics) would be useful. Although to date very few studies have integrated skin metabolomics data with at least one other ‘omics’ technology, in the future, this approach will be able to provide simple and fast tests that can be routinely applied in both clinical and cosmetic settings for the identification of numerous skin diseases and conditions. It will also be possible to create large archives of multi-omics data that can predict individual responses to pharmacological treatments and the efficacy of different cosmetic products on individual subjects by means of specific allotypes, with a view to increasingly tailor-made medicine. In this review, after analyzing the complexity of the skin ecosystem, we have highlighted the usefulness of this emerging integrated omics approach for the analysis of skin problems, starting with one of the latest ‘omics’ sciences, metabolomics, which can photograph the expression of the genome during its interaction with the environment.

Keywords: skinomics; multiomics; precision skin care; skin metabolome; system biology

Hiroyasu Iwahashi1 | Yoshihito Kawashima1 | Hitoshi Masaki2,3 | Atsushi Taga4,5

1Research Center, Maruzen Pharmaceuticals Co., Ltd., Hiroshima, Japan | 2Laboratory of Photoaging Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Tokyo, Japan | 3Research Institute for Human Health Science, Konan University, Hyougo, Japan | 4Pathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kindai University, Osaka, Japan | 5Antiaging Center, Kindai University, Osaka, Japan

Correspondence: Hiroyasu Iwahashi (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 7 June 2024 | Revised: 7 January 2025 | Accepted: 7 January 2025

Funding: The authors received no specific funding for this work.

Keywords: Endo180 | Melissa officinalis | photoaging | type I collagen | wrinkle

Jean-Michel Amici1 | Guénaelle Le Dantec2 | Ann' Laure Demessant2 | Catherine Queille-Roussel3 | Magali Procacci Babled3 |

Anne Claire Cathelineau3 | Alix Danoy4 | Solene Trevisan4 | Merete Haedersdal5,6

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.

1 Service de Dermatologie, Hôpital Saint André, Bordeaux, France | 2La Roche-Posay Laboratoire Dermatologique, Levallois-Perret, France | 3CPCAD, CHU Nice, Nice, France | 4Newtone Technologies–A QIMA Life Sciences Company, Lyon, France | 5Department of Dermatology, Copenhagen University Hospital, Copenhagen, Denmark | 6Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark

Correspondence: Ann' Laure Demessant (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 31 July 2024 | Accepted: 18 September 2024

Funding: This study was supported by La Roche-Posay Laboratoire Dermatologique, France.

Keywords: dermocosmetic | post-procedure | re-epithelization | superficial CO2 laser | vitamin B5