Bárbara Maria Farias Kruschewsky1 · Roseanne Montargil Rocha1 · Marcelo Araújo2 · Rafael Ernane Andrade3 · Icaro J. S. Ribeiro1
Received: 17 February 2026 / Accepted: 12 April 2026 © The Author(s) 2026
Abstract
Aims To identify patterns of complication burden among individuals with diabetes mellitus based on sociodemographic, behavioral, and clinical characteristics, and to examine their co-occurrence with diabetes-related comorbidities.
Methods This cross-sectional study was conducted during a diabetes health campaign in a municipality in southern Bahia, Brazil, involving 1,542 patients. Data were obtained through a standardized questionnaire and ophthalmological examina-tions. Latent class analysis was applied to identify subgroups with similar clinical characteristics. Models with two to four classes were estimated, with the two-class model presenting the most parsimonious and interpretable solution according to BIC. Associations between classes and comorbidities were estimated using Poisson regression with robust variance, adjusted for age and sex.
Results Two classes were identified. Class 1 (86.6%) showed lower complication burden, with preserved vascular and sen-sory function. Class 2 (13.4%) was characterized by a higher frequency of ulceration, amputation, absent peripheral pulses, and impaired protective sensation. Individuals in Class 2 presented higher prevalence of cardiovascular disease (PR=1.47), myocardial infarction (PR=1.64), neurological disease (PR=1.67), and retinopathy (PR=1.63).
Conclusion The identified classes primarily reflect differences in peripheral complication burden, with higher co-occurrence of vascular and microvascular conditions in the more affected group. These findings describe patterns of complication clus-tering within a screening population and may support population-level strategies for identifying individuals with greater healthcare needs.
Keywords Diabetes mellitus · Risk stratification · Latent class analysis
Merve Oruc1 · Ozant Helvacı2 · Ahmet Oruc3 · Ulver Derici2
Received: 13 February 2026 / Accepted: 12 April 2026 © The Author(s) 2026
Background Orthostatic hypotension (OH) is associated with adverse cardiovascular outcomes and may reflect underlying autonomic and vascular dysfunction. Arterial stiffness is a key determinant of cardiovascular risk; however, its relationship with OH in patients with diabetes mellitus (DM) remains unclear.
Objective To evaluate factors associated with OH and investigate the relationship between arterial stiffness parameters and OH in patients with DM.
Methods This single-center cross-sectional study included 193 patients with DM. Orthostatic blood pressure was measured in the supine position and 3 min after standing. Arterial stiffness was assessed using oscillometric pulse wave velocity (PWV) and related parameters with the Mobil-O-Graph device. Clinical, laboratory, and medication data were analyzed. Logistic regression analyses were performed to identify factors associated with OH.
Results OH was present in 56 patients (29%). Patients with OH had significantly higher central blood pressure and arterial stiffness parameters, including PWV, augmentation pressure, and augmentation index. In multivariate analysis, female sex, older age, diabetic neuropathy, and PWV were independently associated with OH. PWV remained significantly associated with OH after adjustment for confounders. No significant differences were observed between groups regarding antihyper-tensive medication classes.
Conclusion In patients with DM, OH is independently associated with increased arterial stiffness and diabetic neuropathy. These findings suggest a link between orthostatic blood pressure dysregulation and adverse vascular characteristics. Prospec-tive studies are needed to clarify causal relationships and clinical implications.
Keywords Orthostatic hypotension · Arterial stiffness · Pulse wave velocity · Diabetes mellitus · Cardiovascular autonomic neuropathy
Communicated by Salvatore Corrao, M.D
Merve Oruc
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1 Department of Nephrology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey
2 Department of Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey
3 Department of Medical Oncology, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey
放射性溃疡就是哪个部位受放疗，就会引起放射性溃疡。常见的放射性溃疡往往是根据肿瘤的发生部位以及放射治疗需要放疗的部位来引起的，比较常见的包括颈部、胸部，因为女性的乳腺癌发生率较高。
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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