Wang Shuaishuai 1† , Zhu Tongtong1† , Wang Dapeng2 ,
Zhang Mingran1 , Wang Xukai 1 , Yu Yue1 , Dong Hengliang1 ,
Wu Guangzhi 1 * and Zhang Minglei 1 *
1 Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China,
2 Department of Orthopedics, Siping Central Hospital, Siping, China
EDITED BY
Xiaoyuan Li,
Northeast Normal University, China
REVIEWED BY
Fuzeng Ren,
Southern University of Science and
Technology, China
Gong Cheng,
Harvard University, United States
Ruogu Qi,
Nanjing University of Chinese Medicine,
China
*CORRESPONDENCE
Wu Guangzhi,
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Zhang Minglei,
†
These authors have contributed equally to this work
SPECIALTY SECTION
This article was submitted to Biomaterials, a section of the journal
Frontiers in Bioengineering and Biotechnology
RECEIVED 27 October 2022
ACCEPTED 18 January 2023
PUBLISHED 30 January 2023
CITATION
Shuaishuai W, Tongtong Z, Dapeng W, Mingran Z, Xukai W, Yue Y, Hengliang D, Guangzhi W and Minglei Z (2023), Implantable biomedical materials for treatment of bone infection.
Front. Bioeng. Biotechnol. 11:1081446.
doi: 10.3389/fbioe.2023.1081446
COPYRIGHT
© 2023 Shuaishuai, Tongtong, Dapeng, Mingran, Xukai, Yue, Hengliang, Guangzhi and Minglei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The treatment of bone infections has always been difficult. The emergence of drugresistant bacteria has led to a steady decline in the effectiveness of antibiotics. It is also especially important to fight bacterial infections while repairing bone deffects and cleaning up dead bacteria to prevent biofilm formation. The development of biomedical materials has provided us with a research direction to address this issue.
We aimed to review the current literature, and have summarized multifunctional antimicrobial materials that have long-lasting antimicrobial capabilities that promote angiogenesis, bone production, or “killing and releasing.” This review provides a comprehensive summary of the use of biomedical materials in the treatment of bone infections and a reference thereof, as well as encouragement to perform further research in this field.
KEYWORDS
biological materials, bone infection, multifunctional material, implantable material, treatment of bone infection, progress of infection treatment, multifunctionalization of materials
This article is excerpted from the 《 Frontiers in Endocrinology》 by Wound World
创伤是指由于各种致伤因素导致的机体软组织、骨骼甚至内脏器官等等各个系统的损伤,创伤可以根据发生地点、受伤部位、受伤组织、致伤因素及皮肤完整程度进行分类。 按发生地点分为战争伤、工业伤、农业伤、交通伤、体育伤、生活伤等;按受伤部位分为颅脑创伤、胸部创伤、腹部创伤、各部位的骨折和关节脱位、手部伤等;按受伤类型分为骨折、脱位、脑震荡、器官破裂等;相邻部位同时受伤者称为联合伤(如胸腹联合伤);按受伤的组织或器官分类时,又可按受伤组织的深浅分为软组织创伤、骨关节创伤和内脏创伤。软组织创伤指皮肤、皮下组织和肌肉的损伤,也包括行于其中的血管和神经。单纯的软组织创伤一般较轻,但广泛的挤压伤可致挤压综合征。血管破裂大出血亦可致命。骨关节创伤包括骨折和脱位,并按受伤的骨或关节进一步分类并命名。如股骨骨折、肩关节脱位等。内脏创伤又可按受伤的具体内脏进行分类和命名。如脑挫裂伤、肺挫伤、肝破裂等。同一致伤原因引起两个以上部位或器官的创伤,称为多处伤或多发伤。按致伤因素,分为火器伤、切伤、刺伤、撕裂伤、挤压伤、扭伤、挫伤等。按皮肤完整程度,分为闭合性创伤、开放性创伤等。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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