Maheshvari N. Patel , Nayan K. Patel , Apeksha M. Merja , Saurav Patnaik
1. Clinical Research, NovoBliss Research Private Limited, Ahmedabad, IND 2. Pharmacology, Swaminarayan University, Ahmedabad, IND 3. Dermatology, NovoBliss Research Private Limited, Ahmedabad, IND 4. Cosmetology, Anveya Living Private Limited, Gurgaon, IND
Corresponding author: Maheshvari N. Patel, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Review began 09/06/2024
Review ended 09/18/2024
Published 09/23/2024
© Copyright 2024
Patel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.7759/cureus.69968
Categories: Dermatology
Keywords: dark spots, facial cleanser and serum, porphyrins, iga scoring, niacinamide, acne
1, 2 1 3 4
Open Access Original Article
How to cite this article
Patel M N, Patel N K, Merja A M, et al. (September 23, 2024) Clinical Evaluation of the Efficacy, Safety, and In-Use Tolerability of a Diacnemide™-Containing Acne Kit (Facial Serum and Cleanser) Regimen for the Synergistic Management of Facial Acne in Adults. Cureus 16(9): e69968.
DOI 10.7759/cureus.69968
Jun Yan Ng1 , Qi Yi Ambrose Wong1 , Jun Jie Lim1 , Dingyu Cen1 , Jia Yi Karen Wong1 , Yi Ying Eliza Lim1 , Yang Yie Sio1 , Kavita Reginald1,2 , Yee‑How Say1,2,3 and Fook Tim Chew1,4*
*Correspondence:
Fook Tim Chew
该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Full list of author information is available at the end of the article
Abstract
Background Skin ageing takes on many diferent forms. Despite this diversity in skin ageing phenotypes, literature published to date is limited in scope, as many research studies either focus on one single phenotype or just a few specifc phenotypes. Presently, phenotypes such as wrinkles, pigment spots, and photo-ageing are receiving most of the research attention. We therefore wonder whether the current discourse on skin ageing places a disproportion‑ate amount of focus on a few selected phenotypes, leaving other skin ageing phenotypes underexplored.
Methods In this cross-sectional study, we performed a broad assessment of forty-one signs of skin ageing and characterised the phenotypes that constituted key components of skin ageing. We also explored the interrelationship among forty-one skin ageing phenotypes using Spearman’s Correlation and Principal Component Analysis.
Results We analysed our study population, which is composed of 3281 ethnic Chinese participants from the Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES). The first ten principal components cumulatively explain 46.88% of the variance of skin ageing phenotypes in our study population. We discovered that the commonly discussed forms of skin ageing (i.e., wrinkles, pigmentation, and photo-ageing) only accounted for a small portion (24.39%) of the variance of all skin ageing phenotypes in our study population. Telangiectasia, a poor lip fullness, a lighter skin colour, xerosis, ephelides (freckles), ptosis of eyelids (droopy eyelids), eyebags, and a low eyebrow positioning were other key components of skin ageing, accounting for a further 22.49% of the variance of skin ageing phenotypes in our study population. We found that each of these ten skin ageing phenotypes characterises a key and important aspect of skin ageing. In this broad assessment of skin ageing, we frst described the prevalence of forty-one signs of skin ageing and then characterised in detail both the prevalence and severity distribution of ten key skin ageing phenotypes.
Conclusions We presented clear evidence that skin ageing is much more than just wrinkles, pigmentation and photo-ageing. The addition of telangiectasia, poor lip fullness, a lighter skin colour, xerosis, ephelides, ptosis of eyelids, eyebags, and a low eyebrow positioning added more dimensions to skin ageing phenotype presentations.
Keywords Skin aging, Skin ageing, Broad assessment, Cross-sectional study, Wrinkling, Sagging, Principal Component Analysis, Chinese, Singapore/Malaysia Cross-sectional Genetics Epidemiology Study, SMCGES
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
在医学上，皮肤病是有关皮肤的疾病，是严重影响人民健康的常见病、多发病之一，如麻风、疥疮、真菌病、皮肤细菌感染等。皮肤病是皮肤（包括毛发和甲）受到内外因素的影响后，其形态、结构和功能均发生变化，产生病理过程，并相应的产生各种临床先后表现。皮肤病的发病率很高，多比较轻，常不影响健康，但少数较重甚至可以危及生命。
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
扫一扫了解详情:
任何关于疾病的建议都不能替代执业医师的面对面诊断。所有门诊时间仅供参考，最终以医院当日公布为准。
网友、医生言论仅代表其个人观点，不代表本站同意其说法，请谨慎参阅，本站不承担由此引起的法律责任。
