王昳娜¹，何振华¹，周瑾¹，孙晓芬²

1.绍兴文理学院元培学院，浙江 312000；2.浙江中医药大学附属第二医院

Research progress on the application of hypochlorous acid in wound care

WANG Yi'na，HE Zhenhua，ZHOU Jin，SUN Xiaofen

Shaoxing University，Yuanpei College，Zhejiang 312000 China

Keywords hypochlorous acid solution；wound；infection；bacterial biofilm；clinical application；review

摘要 介绍了次氯酸溶液的发展史、杀菌机制、特点、与其他伤口清洁消毒剂的比较、使用方法以及当前研究的不足，旨在为次氯酸

溶液在伤口治疗、护理中的应用提供依据。

关键词 次氯酸溶液；伤口；感染；细菌生物膜；临床应用；综述

本文献转载于红会烧伤，不代表本网站赞同其观点和对其真实性负责，我们只是用于阅读分享，非商业用途，如若侵权，请告知删除。

杨金燕¹，孙丹¹，夏婷婷¹，施施¹，杨育卉²，闫中强^1.3

1.解放军总医院海南医院疾病预防控制科2.血液科，海南 三亚 572014；3.解放军总医院第二医学中心疾病预防控制科，北京 100039

摘要:次氟酸消毒剂以其强大的消毒杀菌能力和环境友好特性，在医疗领域得到广泛关注及应用。有效浓度的次氟酸不仅能高效杀灭细菌、病毒等微生物,同时具有低毒、无残留、低腐蚀性等优势,适用于各种精密设备及复杂的医疗场景。次氯酸消毒剂可用于儿科病房、血液透析室等重点医疗场所的环境消毒。此外，在口腔护理、伤口处理、手术部位消毒等领域展现了独特的优势。本文探讨了次氯酸消毒剂的性能,为其在医疗机构的合理应用提供参考。随着清洁消毒技术的不断进步和应用的深入拓展，次氟酸消毒剂在医疗领域的应用前景将更加广阔。

关键词:次氯酸；次氯酸消毒剂；医疗机构；理化性质；临床消毒

中图分类号:R187 文献标识码:A 文章编号:1005-4529（2025）03-0476-05

Progress of research on clinical application of hypochlorous acid disinfectant

YANG Jinyan*，SUN Dan，XIA Tingting，SHI Shi，YANG Yuhui，YAN Zhongqiang*  Hainan Hos pital of PLAGeneral Hospital，Sanya ，Hainan 572014，China

Abstract: Hypochlorous acid disinfectant has been widely noticed and applied in the medical field due to its power-ful disinfecting and sterilizing ability and environmental friendly characteristics.Effective concentration of hypo-chlorous acid disinfectant can not only efficiently kill bacteria,viruses and other microorganisms, but also has theadvantages of low toxicity,no residue and low corrosion，which is suitable for all kinds of complicated equipmentand complex medical scenarios,It can be used for environmental disinfection in major medical places such as pedi-atric wards and hemodialysis rooms,In addition,it demonstrates unique advantages in the oral care,wound treat-ment， and surgical site disinfection, This article explores the properties of hypochlorous acid disinfectant to pro-vide reference for the reasonable application in healthcare facilities,With the continuous progress of cleaning anddisinfection technology and ir-depth expansion of application,the prospect of hypochlorous acid disinfectant appli-cation in the medical field will be broader.

Key words:Hypochlorous acid;Hypochlorous acid disinfectant; Medical institution;Physicochemical property;Disinfection

高晓东',胡必杰',鲍容3

(1.复旦大学附属中山医院感染管理科2.临床微生物试验室，上海200032)

摘要:目的探讨次氯酸对皮肤软组织感染常见病原体(包括标准茁株及临床茁株)的体外杀菌效果,为临床应用提供依据。方法﹐根抛《消毒技术规范》将0.5左氏单位的临床分离茁株菌悬液与次氯酸作用1 min和10 min,然后将作用后的液体与中和剂混合中和消毒效果,普通病原体的混合液取1.0 ml进行琼脂倾注法培养,化脓性链球菌和非结核分枝杆菌的混合液取0.1 ml分别在血平板和7H10平板上进行涂布法培养;除非结核分枝杆菌培养7d外,其他病原体培莽48h后进行融落计数,计算杀A对数值。结果﹐次氯酸作用标准開株1 min或10min均可将菌量从0.5麦氏单位(相当于10⁷)降剑0;临床菌株包括化脓性链球菌、耐甲氧两林金黄色懒萄球菌(MRSA).耐碳青霉烯类的鲍氏不动朴菌(CRAB).耐碳青霉烯类的铜绿假弟胞菌(CRPA).耐碳青霉烯类的肺炎克需伯杆南(CRKB),脓肿分枝杆南、色分枝杆開和产气荚膜杆開也得到同样结果。结论﹐本试验首次系统全面检测次氛酸对皮肤软组织感染常见的病原体(包括非结核分枝杆開,厌氧掬,真南等)均有很好的体外杀南活性，可以作为感染伤口的局部爪药。

关键词:次氯酸;皮肤软组纠感染;病原体

中图分类号:R187文献标识码:A文章编号:I005 4529(2017)081714 03

Effectiveness of hypochlorous acid solution against common pathogens of skin and soft tissue infection in vitro

GAO Xiao-dong，HU Bi-jie，BAO Rong

(Zhongshan Hospital of Fudan University ，Shanghai 200032，China)

Abstract:ORJECTIVE To investigale the gertmicidal elficientey of hypochlorous acid solution sgainst cotutmotLpathogcns (Inucluding staudeurd strainus anud clinical strains) of skin atnud solt tissuc inlcetion in vitro.so as to provil:the bosis for improving the boctericidal effect.METHODSAccording to " technical standord for disinfection" ,acertain concentrotion of pothogens of clinical isolates wos treated with hypochlorous ocid solution for 1 min or 10 min,anud then the action of the solution anud neutralizer were tmuixeud, 1.0ml of the tuixlure of cotmtmot.puthogens was used lor agar pouring culure,0. 1 ml of the tuixlure ol Sireplococcus pyogenes anud nontuberulosismycobecterie were cultured using the cooting method in the blood plate and 7H10 plate.Unless the nontuberculo-sis mycohscteria was cultured for 7 d, the other pathogens were cultured for 48 h and the colonies were counted.RESULTS Treatment of hypochlorous acid solution for 1 min or 10 min could decrease the amount of bacte-ris from 0.5 Maxwell units (equivalent to 10⁷) to 0.The clinical isolstes of S. pyogenes，methicillin-resistantSta phylococcus aureus (MRSA)，carbepenem-resistant Acinetobacter baumannii(CRAR),carbapenem-resistantlP'seudomonas aeruginosa (CRPA),carhapenen-resistant Klebsiella pneumoniae(CRKB),Mycohacterium ab-scess ,Mycobacterium tuberculosis , and Clostridium per fringens also got the sxatme results,CONCLUISION Hypo-chlorous acid solution has good germicidal efficiency against common pethogens of skin and soft tissve infection imvittro,and it can be used as topical treatment for infected wounds.

Key words:Hypochlorous acid solution; Skin and soft tissue infection;Pathogens