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Molecular farming expression of recombinant fusion proteins applied to skincare strategies

Artificial Intelligence in the Evolution of Customized Skincare Regimens

Periprocedural Skincare for Nonenergy and Nonablative Energy-Based Aesthetic Procedures in Patients With Skin of Color

An Optical-Fiber-Based Smart Textile (Smart Socks) to Manage Biomechanical Risk Factors Associated With Diabetic Foot Amputation

Bijan Najafi, PhD, MSc1,2 , Hooman Mohseni, PhD3 , Gurtej S. Grewal, PhD2 , Talal K. Talal, DPM4 , Robert A. Menzies, MSc4 , and David G. Armstrong, DPM, MD, PhD2

Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA

2 Southern Arizona Limb Salvage Alliance (SALSA), Department of Surgery,University of Arizona, Tucson, Arizona, USA

3 Electrical Engineering and Computer Sciences, McCormick School of Engineering; Physics and Astronomy, Weinberg College of Arts and Sciences; Northwestern University, Evanston, IL, USA

4 Diabetic foot and Wound Clinic, Department of Medicine, Hamad Medical Co, Doha, Qatar

Corresponding Author:

Bijan Najafi, PhD, MSc, Interdisciplinary Consortium on Advanced Motion Performance, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, One Baylor Plaza, MS:BCM390, Houston, TX 77030, USA. Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Journal of Diabetes Science and Technology 2017, Vol. 11(4) 668–677

© 2017 Diabetes Technology Society Reprints and permissions: sagepub.com/journalsPermissions.nav DOI: 10.1177/1932296817709022  journals.sagepub.com/home/dst

Abstract

Objective: This study aimed to validate a smart-textile based on fiber-optics for simultaneous measurement of plantar temperature, pressure, and joint angles in patients with diabetic peripheral neuropathy (DPN).

Methods: After in-vitro validation in the laboratory, 33 eligible subjects with DPN were recruited (age: 58 ± 8 years, BMI: 31.5 ± 8 kg/m2 ) for assessing plantar pressure and temperature during habitual gait-speed in a clinical-setting. All participants were asked to walk at their habitual speed while wearing a pair of sensorized socks made from highly flexible fiber optics (SmartSox). An algorithm was designed to estimate temperature, pressure, and toe range of motion from optical wavelength generated from SmartSox. To validate the device, results from thermal stress response (TSR) using thermography and peak pressure measured by computerized pressure insoles (F-Scan) were used as gold standards.

Results: In laboratory and under controlled conditions, the agreements for parameters of interest were excellent (r > .98, P = .000), and no noticeable cross-talks between measurements of temperature, angle, and pressure were observed. During clinical data acquisition, a significant correlation was found for pressure profile under different anatomical regions of interest between SmartSox and F-Scan (r = .67, P < .050) as well as between thermography and SmartSox (r = .55, P < .050).

Conclusion: This study demonstrates the validity of an innovative smart textile for assessing simultaneously the key parameters associated with risk of foot ulcers in patients with DPN. It may empower clinicians to objectively stratify foot risk and provide timely care. Another study is warranted to validate its clinical application in preventing limb threating problems in patients with DPN.

Keywords

diabetic foot ulcer, SmartSox, wearable, fiber optics, plantar pressure, plantar temperature

Comprehensive cost-of-illness analysis of pressure ulcer treatment: A real-world study at a Czech university hospital

Lenka Krupova
1 | Andrea Pokorna
2,3 | Miroslav Krupa4 | Klara Bene
sov ˇ a
3

1 Department of Dermatology, University Hospital Ostrava, Ostrava, Czech Republic

2 Department of Health Sciences, Faculty of Medicine, Masaryk University, Brno, Czech Republic

3 Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic

4 Faculty of Business Administration, Prague University of Economics and Business, Prague, Czech Republic

Correspondence

Andrea Pokorn
a, Department of Health Sciences, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic. Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Funding information

Ministerstvo Zdravotnictví Ceské Republiky, Grant/Award Number: NU20-09-00094

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

© 2025 The Author(s). International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Abstract

Pressure ulcers (PUs) impose a significant economic burden on healthcare sys tems, affecting patient quality of life and leading to substantial treatment costs. This study presents a cost-of-illness analysis of PU treatment in hospitalized patients in the Czech Republic, based on real-world clinical data. The analysis was conducted using a comprehensive methodology at a Czech university hos pital, involving 304 hospitalizations. The study included all hospitalized patients with PUs. Data were collected employing a bottom-up, person-based approach, which refers to the collection and analysis of cost data at the individ ual patient level. This method captures detailed resource utilization for each patient. The methodology accounted for both systemic and local costs, includ ing materials, medications, caregiver time, and procedures. The study involved 304 hospitalizations, with a mean length of stay of 13 days. The total cost of PU treatment, excluding pharmacotherapy, had a median of €678, while including pharmacotherapy, the median cost rose to €929. Younger patients incurred higher treatment costs. Significant cost variations were observed among different departments. We developed and applied a novel cost model to quantify the expenses associated with PUs, which accurately highlighted the financial burden in the hospital care setting. We present a rigorous methodol ogy for PU cost-of-illness analysis, providing a valuable tool for future research and clinical practice. This comprehensive approach supports the development of targeted interventions to reduce the incidence and severity of PUs, ulti mately improving patient care and reducing healthcare costs.

KEYWORDS

cost analysis, healthcare costs, patients, pressure ulcers, treatment costs

Key Messages

Accurate cost-of-illness analysis of pressure ulcer treatment is crucial for improving patient outcomes and reducing healthcare costs.

This study developed a methodology to calculate PU treatment costs, using data from 304 hospitalizations at a Czech university hospital.

The median PU treatment cost was €678 (excluding pharmacotherapy) and €929 (including pharmacotherapy), with significant cost variations across

The cost model provides a tool for targeting interventions in pressure ulcers' management to reduce financial burden and enhance patient care.