Macrocystis pyrifera ferment-containing creams for optimizing facial skin rejuvenation

Michael Gold MD FAAD¹ | Yoon-Soo Cindy Bae MD FAAD² | David J. Goldberg MD JD FAAD^3,4 | Sumayah Jamal MD PhD⁵ | Amy B. Lewis MD⁶ | Shari Marchbein MD FAAD⁷ | Adriana Ros DO⁸ | Uma Santhanam PhD⁹ | Lisa DiNatale^9,10 | Jaime Emmetsberger PhD^9,10

细胞衰老与衰老相关疾病研究进展

田潇雨 卢娜

中国药科大学，中国·江苏 南京 210000

摘 要

衰老(Senecence)是细胞功能逐渐退化的一种状态，在这种状态下细胞几乎丧失复制能力，并且细胞周期抑制基因p16INK4a 的表达升高。细胞衰老贯穿生物个体的整个生命过程，在各种生理以及病理过程中发挥重要的作用。一方面，衰老的细胞能够促进胚胎发育，伤口愈合和宿主免疫反应以及抑制肿瘤发生发展等。另一方面，随着年龄增长而在体内积累的衰老细胞也会对机体带来有害的影响。这些不能增殖的细胞产生衰老相关分泌表型(Senescence-Associated Secretory PhenotypeSASP)，促进衰老相关疾病(Aging-related Diseae)的发生发展，而清除衰老细胞能够减缓衰老相关疾病的症状。因此寻找能够特异性杀死衰老细胞的药物(Senolytics)成为了抗衰老领域的研究重点。

关键词
细胞衰老;衰老相关分泌表型;衰老相关疾病;抗衰老;Senolytics

Advances in Research on Senescence in Health and Diseases

Xiaoyu Tian Na Lu

China Pharmaceutical University, Nanjing, Jiangsu, 210000, China

AbstractSenescence is a state in which the cell's functional characteristics are gradually deteriorating, in which the cell is at a sustained lowevel ofreplication and is accompanied by an increase in the expression of the cell cycle inhibitor pl6lNK4a The production of senescent cells occurs throughout life and plays key roles in various physiological and pathological proceses. These noneproliferating celsoccupy key cellular niches and produce senescence-associated secretory phenotype (SASP) which contributes to aging-related diseasesprogress. Therefore, the search for Senolytics has become the focus ofresearch in the field of anti-aging.

Keywords
cellular senescence, SASP, aging-related disease, anti-senescence, senolytics

间充质干细胞抗衰老的理论研究进展

刘淼  叶俊儒
(成都医学院第一附属医院，成都610000)
【摘要】研究抗衰老是当今社会的热点课题。干细胞是具有自我更新能力和多向分化能力的细胞,间充质干细胞包含其中。研究常用的间充质干细胞有骨髓间充质干细胞和脂肪间充质干细胞,二者均在组织修复和抗衰老方面有广泛的应用,有很好的发展前景。本文综述了近年来脂肪间充质干细胞抗衰老作用的特点、机制及应用研究进展。

【关键词】干细胞;骨髓间充质干细胞;脂肪间充质干细胞;抗衰老;组织修复【中图分类号】R725【文献标识码】A【文章编号】1005-1457(2017)04-30-7

Advances in the Theoretical Research of Mesenchymal Stem Cells

Liu Miao Ye Junru

( The first affiliated hospital ofchengdu medical college ,chengdu 610000 , China)
Research on aging is a hot topic in today's society, Mesenchymal stem cells is a kind of stem cells, hasAbstraettheability to self-renewal and multi-directional differentiation potential, Research between commonly used there arebone marrow mesenchymal stem cells and adipose mesenchymal stem cells, mesenchymal stem cells between both intissue repair and anti-aning has a wide range of applications, In this paper,the characteristics,mechanism and applica-tion of the anti-aging effect of adipose mesenchymal stem cells in recent years are reviewd.

【Key words】Stem Cells; Bone Marrow mesenchymal stem cells; Adipose Mesenchymal stem cells; Ant- Aging; Tissue repair

眼周年轻化联合治疗方案的临床管理

章 晾

（武汉美莱医疗美容整形医院，湖北 武汉，430000）

【摘 要】 目的 探讨应用手术和非手术联合治疗方案恢复眼周年轻化的临床管理概念。方法 综合分析患者眼周衰老临床表现，选择上睑松弛矫正术、眼袋整形术等手术治疗方案联合肉毒素、玻尿酸、光电治疗等非手术治疗方案进行个性化的治疗。

结果 患者 22 例，术后回访 3-18 个月，眼周年轻化联合治疗方案越全面效果满意度越高。结论 应针对眼周衰老制定个性化联合治疗方案，达到眼周年轻化的目的。

【关键词】眼周年轻化；眼整形术；肉毒素；透明质酸；单极射频

DOI：

The clinical management of the combined treatment of peri-orbital rejuvenation ZHANG Liang (Mylike Cosmetic Hospital, Hubei Province, 430000, China)

[ABSTRACT] Objective To explore the concept of clinical management in the application of combined surgical and non-surgical treatment to restore the peri-orbital rejuvenation. Methods The clinical manifestations of peri-orbital aging were analyzed comprehensively, and surgical treatment (Blepharoplasty and Eyebag surgery ) combined with non-surgical treatment was selected. Non-surgical treatment includes: Botulinum toxin injection , Laser therapy (Radio frequency ; Picosecond) and Microneeding therapy. Results 22 patients were followed up for 3-18 months. The more comprehensive the treatment, the higher the satisfaction. Conclusion It is necessary to make a Personalized combination therapy for peri-orbital aging, so as to achieve the goal of peri-orbital

[KEY WORDS] peri-orbital rejuvenation; Blepharoplasty; botulinum toxin; hyaluronic acid; monopolar radiofrequency

抗衰老药物的研究进展

何晨1，刘晶晶1，陈楠1，段路娟1，王斓星1，王丽丽2+(1．河北农业大学生命科学学院，保定071000；2．河北农业大学中国枣研究中心，保定071000)

摘要：目的

总结近年来研究人员在抗衰老药物研究领域的发现，为后期研究提供参考。方法通过查阅近5年的相关文献，对抗衰老药物进行分类归纳。结果抗衰老药物大致可分为中药类(如当归、人参和蜂王浆等)、小分子类(如二甲双胍、白藜芦醇、原花青素和雷帕霉素)和多肽类(如大米多肽、大豆多肽和人工合成多肽)，通过构建不同的生物模型(如D半乳糖致衰老小鼠模型、p53基因敲除斑马鱼模型和秀丽隐杆线虫模型等)可证实其抗衰老作用。结论尽管抗衰老药物的作用效果得到了证实，但其分子作用机制有待进一步阐明。

关键词：抗衰老药物；中药类；小分子类；多肽类

DOI：10．3969／i．issn．1004—2407．2020．01．035

中图分类号：R977

文献标志码：A

文章编号：1004—2407(2020)01一0154一04

点阵二氧化碳激光对眶周皮肤年轻化有效性、 安全性和满意度的系统综述及荟萃分析

袁 悦1 ，纪晓晖1 ，顾敬喜2 ，陈官芝1*

1 青岛大学附属医院皮肤科，山东 青岛

2 山东省郯城县皮肤病防治站，山东 临沂

收稿日期：2024年2月27日；录用日期：2024年3月21日；发布日期：2024年3月29日

摘 要

目的：点阵CO₂激光疗法在改善皮肤老化方面已经得到了广泛的应用，由于眶周皮肤的脆弱、易造成瘢痕的特性，目前针对眶周皮肤年轻化的激光治疗开展较少。本研究旨在确定点阵CO₂激光联合疗法在眶周皮肤再生表面修复中的有效性和安全性。方法：截至2023年12月01号，在3个主要数据库中进行了系统搜索。纳入的研究包括点阵CO₂激光或联合其他疗法来改善眼周老化的有效性及并发症，并报告了治疗的有效性和安全性；多篇文章报道同一组患者时，选择最近的报道完整数据的文章。排除标准包括体外研究、动物研究、未使用点阵CO2激光、专家述评、书信、会议摘要、数据不完整或不能获取、CO2点阵激光治疗但未声明关于眶周皱纹或年轻化的研究。结果：筛选后纳入7项临床试验，共纳入166例患者。研究汇总发现眶周皮肤老化及皱纹深度绝大部分都得到了改善，大多数患者都对这项技术感到满意。研究中发现患者在CO2激光术后耐受性良好，主要产生的并发症有包括红斑(n = 8)、色素沉着过度(n = 8)、渗出、渗血、局部水肿、结痂、疼痛、灼热、瘙痒、水疱等。随访时均再未观察到疱疹感染等其他不良反应。术后7天无瘢痕及表皮萎缩再形成。大多数并发症轻微且短暂。治疗后红斑发生率为0.10 (95% CI:0.03~0.18, p < 0.01)，色素沉着发生率为0.08 (95% CI: 0.03~0.16, p < 0.01)。结论：研究发现，点阵CO2激光治疗眶周皮肤年轻化是有效且安全的。由于缺乏高质量的报告，有必要进行更多的试验来证实这些结果。

关键词 年轻化，点阵CO₂ 激光，眶周，Meta分析

A Systematic Review and Meta-Analysis of Efficacy, Safety, and Satisfaction Rates of Fractional CO₂ Laser in Periocular Skin Rejuvenation

Yue Yuan1, Xiaohui Ji1, Jingxi Gu2, Guanzhi Chen1*

1 Dermatology Department, The Affiliated Hospital of Qingdao University, Qingdao Shandong

2 Skin Disease Prevention Station of Tancheng County, Shandong Province, Linyi Shandong Received: Feb. 27th, 2024; accepted: Mar. 21st , 2024; published: Mar. 29th, 2024

Abstract

Objective: Fractional CO₂ laser therapy has been widely used in improving skin aging. Due to the fragile and scarring properties of periorbital skin, laser therapy for periorbital skin rejuvenation is rarely carried out now. The aim of this study was to determine the efficacy and safety of fractional CO₂ laser combined therapy in periorbital skin regeneration surface repair. Methods: As of December 01, 2023, a systematic search was conducted in three major databases. Included studies included the efficacy and complications of fractional CO₂ laser or combined with other therapies to improve periocular aging, and reported the efficacy and safety of the treatment. When multiple articles report on the same group of patients, select the most recent article reporting completedata. Exclusion criteria included in vitro studies, animal studies, no use of a fractional CO₂ laser, expert reviews, letters, conference abstracts, incomplete or unavailable data, and studies on periorbital wrinkles or rejuvenation that did not claim fractional CO₂ laser treatment. Results: After screening, 7 clinical trials were included, involving a total of 166 patients. The study summary found that periorbital skin aging and wrinkle depth were largely improved, and most patients were satisfied with this treatment. The study found that patients were well tolerated after fractional CO₂ laser surgery, and the main complications included erythematosis (n = 8), hyper pigmentation (n = 8), exudation, bleeding, local edema, scab, pain, burning, pruritus, blisters, etc. No other adverse reactions such as herpes infection were observed during follow-up. No scar or epidermal atrophy was found 7 days after surgery. Most complications were mild and short-lived. The incidence of erythema after treatment was 0.10 (95% CI: 0.03~0.18, p < 0.01), and the incidence of hyper pigmentation was 0.08 (95% CI: 0.03~0.16, p < 0.01). Conclusion: It is found that fractional CO₂ laser is effective and safe in the treatment of periorbital skin rejuvenation. Due to paucity of high-quality reportings, additional trials are warranted to corroborate these results.

Keywords Rejuvenation, Fractional CO₂ Laser, Periorbital, Meta-Analysis

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