Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells

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Kick-Starting Wound Healing: A Review of Pro-Healing Drugs 2026-10-28 00:00

Bethany L. Patenall , Kristyn A. Carter and Matthew R. Ramsey *

Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.A.C.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +1-(617)-525-5775

Abstract: Cutaneous wound healing consists of four stages: hemostasis, inflammation, proliferation/repair, and remodeling. While healthy wounds normally heal in four to six weeks, a variety of underlying medical conditions can impair the progression through the stages of wound healing, resulting in the development of chronic, non-healing wounds. Great progress has been made in developing wound dressings and improving surgical techniques, yet challenges remain in finding effective therapeutics that directly promote healing. This review examines the current understanding of the pro-healing effects of targeted pharmaceuticals, re-purposed drugs, natural products, and cell-based therapies on the various cell types present in normal and chronic wounds. Overall, despite several promising studies, there remains only one therapeutic approved by the United States Food and Drug Administration (FDA), Becaplermin, shown to significantly improve wound closure in the clinic. This highlights the need for new approaches aimed at understanding and targeting the underlying mechanisms impeding wound closure and moving the field from the management of chronic wounds towards resolving wounds.

Keywords: chronic wounds; diabetes; wound healing; epithelization; macrophages; biomaterials

Comparative assessment of commercially available wound gels in ex vivo human skin reveals major differences in immune response‑modulatory effects 2026-10-27 00:00

S.Seiser¹ , D. Cerbu¹ , A. Gallhofer¹ , J. Matiasek² & A. Elbe‑Bürger^1*
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Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells

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09 7月 2025

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Author : 伤口世界

Polarity-guided uneven mitotic divisions control brassinosteroid activity in proliferating plant root cells

This is an open access article under the CC BY license.

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Kick-Starting Wound Healing: A Review of Pro-Healing Drugs 2026-10-28 00:00

Bethany L. Patenall , Kristyn A. Carter and Matthew R. Ramsey *

Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.A.C.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +1-(617)-525-5775

Abstract: Cutaneous wound healing consists of four stages: hemostasis, inflammation, proliferation/repair, and remodeling. While healthy wounds normally heal in four to six weeks, a variety of underlying medical conditions can impair the progression through the stages of wound healing, resulting in the development of chronic, non-healing wounds. Great progress has been made in developing wound dressings and improving surgical techniques, yet challenges remain in finding effective therapeutics that directly promote healing. This review examines the current understanding of the pro-healing effects of targeted pharmaceuticals, re-purposed drugs, natural products, and cell-based therapies on the various cell types present in normal and chronic wounds. Overall, despite several promising studies, there remains only one therapeutic approved by the United States Food and Drug Administration (FDA), Becaplermin, shown to significantly improve wound closure in the clinic. This highlights the need for new approaches aimed at understanding and targeting the underlying mechanisms impeding wound closure and moving the field from the management of chronic wounds towards resolving wounds.

Keywords: chronic wounds; diabetes; wound healing; epithelization; macrophages; biomaterials
Comparative assessment of commercially available wound gels in ex vivo human skin reveals major differences in immune response‑modulatory effects 2026-10-27 00:00

S.Seiser¹ , D. Cerbu¹ , A. Gallhofer¹ , J. Matiasek² & A. Elbe‑Bürger^1*
Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers 2026-10-26 00:00

Ewa A. BURIAN¹, Lubna SABAH¹, Klaus KIRKETERP-MØLLER¹, Glenn GUNDERSEN² and Magnus S. ÅGREN^1,3,4

¹Department of Dermatology and Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark, ²SoftOx Solutions AS, Oslo, Norway, ³Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, and ⁴Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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2019广东省医疗行业协会伤口管理分会年会

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2019年6月15日中国广州
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