伤口世界

伤口世界

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Adipose Stem Cell-Based Treatments for Wound Healing

      Wound healing is one of the most complex physiological regulation mechanisms of the human body. Stem cell technology has had a signifificant impact on regenerative medicine. Adipose stem cells (ASCs) have many advantages, including their ease of harvesting and high yield, rich content of cell components and cytokines, and strong practicability. They have rapidly become a favored tool in regenerative medicine. Here, we summarize the mechanism and clinical therapeutic potential of ASCs in wound repair.

Keywords: adipose stem cells, wound healing, regenerative medicine, skin regeneration, inflflammation

A machine learning algorithm for early detection of heel deep tissue injuries based on a daily history of sub-epidermal moisture measurements

Abstract:Sub-epidermal moisture is an established biophysical marker of pressure ulcer formation based on biocapacitance changes in affected soft tissues, which has been shown to facilitate early detection of these injuries. Artificial intelligence shows great promise in wound prevention and care, including in automated analyses of quantitative measures of tissue health such as sub-epidermal moisture readings acquired over time for effective, patient-specific, and anatomical-site-specific pressure ulcer prophylaxis.Here, we developed a novel machine learning algorithm for early detection of heel deep tissue injuries, which was trained using a database comprising six consecutive daily sub-epidermal moisture measurements recorded from 173 patients in acute and post-acute care settings. This algorithm was able to achieve strong predictive power in forecasting heel deep tissue injury events the next day, with sensitivity and specificity of 77% and 80%, respectively, revealing the clinical potential of artificial intelligence-powered technology for hospital-acquired pressure ulcer prevention. The current work forms the scientific basis for clinical implementation of machine learning algorithms that provide effective, early, and anatomy-specific preventive interventions to minimise the occurrence of hospital-acquired pressure ulcers based on routine tissue health status measurements.

KEYWORDS:artificial intelligence, predictive bioengineering modelling, pressure ulcer/injury prophylaxis, preventive interventions, SEM scanner

护理人员医疗器械相关压力性损伤认知 现状及其影响因素研究

摘要 目的:调查护理人员医疗器械相关压力性损伤(MDRPI)认知现状,并分析其影响因素。方法:采用分层抽样法选取2020年5月—2020年7月清远市10所医院的1074名护理人员为调查对象,采用自行设计的问卷对其进行问卷调查,采用多重逐步回归分析研究护理人员 MDRPI认知的影响因素。结果:42.3%的护理人员知晓压力性损伤的最新分期,MDRPI知晓率为86.8%。绝大部分护理人员在为病人护理时选择合适的器械,固定适宜。48.0%的护理人员不会直接将器械放置在病人身上,大部分护理人员使用纱布/棉垫保护器械接触部位皮肤。约43%的护理人员每天2次或3次评估医疗器械接触部位皮肤,52.4%的护理人员每天2次清洁使用器械部位皮肤;气管插管被认为是最容易引起 MDRPI的原因。多重线性回归分析结果显示,职称、医院级别、培训次数为护理人员 MDRPI知识得分的影响因素(P<0.05)。结论:护理人员 MDRPI知识和行为水平有待提高,需加强护理人员 MDRPI相关知识的规范化培训,提高护理人员对 MDRPI的认知和护理行为水平,以降低病人的 MDRPI发生率。

关键词 医疗器械相关压力性损伤;护理人员;认知;影响因素

山楂树皮膏的抑菌作用及对小白鼠 深Ⅱ度烫伤的治疗效果

摘要:目的:研究山楂树皮膏的抑菌作用及对小白鼠深Ⅱ度烫伤的治疗效果。方法:通过水提法获得山楂树皮膏,用滤氏片法来观察膏的抑菌效应;对小白鼠背部进行深Ⅱ度烫伤,用对照实验的方法来观察山楂树皮膏促进烫伤伤口愈合的效果。结果:山楂树皮膏对大肠杆菌、白色念珠菌、金黄色葡萄球菌、枯草芽孢杆菌的生长均有抑制作用,对白色念珠菌抑制效果最为明显;山楂树皮膏可以减少小白鼠背部深Ⅱ度烫伤伤口的感染机率,缩短创面的愈合时间。结论:山楂树皮膏具有广谱的抗菌作用,对动物烫伤有较明显抗感染、促进伤口愈合的作用。

关键词:山楂树皮膏;抑菌作用;深域度烫伤;伤口愈合

恒定封闭式负压联合曲松棉敷料 在难愈性伤口上的应用效果研究

摘 要 :探讨恒定封闭式负压联合曲松棉敷料在难愈性伤口上的应用效果。选 取 2 0 1 8年 8 月一2 0 2 0年 3 月惠州市第一人民医院接受治疗的难愈性伤口患者 3 6 例进行有针对性地观察,根据随机单盲法,将其分为观察组与对照组,每 组 各 1 8 例患者。对照组患者接受传统敷料及常规换药方法,观察组在其基础上采用恒定封闭式负压联合曲松棉敷料治疗,对 比 两 组 患 者 的临床治疗效果。结果 发 现 ,观察组患者伤口愈合率、治疗满意度显著高于对照组,伤 口 感 染 率 及 伤 口 溃 疡 率 均 显 著 低 于 对 照 组 ,平 均 伤 口 愈 合 时 间 、伤口渗液持续时间、平均换药次数及平均住院时间均显著低于对照组(E < 0 . 0 5 ) ,差异有统计学意义。结 论 :恒定封闭式负压联合曲松棉敷料治疗难愈性伤口效果显著,能够有效降低感染风险,改善患者的生活质量。

关 键 词 !难 愈 性伤口;恒定封闭式负压;曲松棉敷料 ;应用效果

藏红花高渗盐水治疗外科难治性伤口2例

摘要:目的 文章通过藏红花高渗盐水用于外科难治性伤口观察伤口愈合情况。方法 对西藏藏医大学附属医院门诊收治的难治性伤口2例患者使用藏红花高渗盐水前后切口愈合情况进行比较、分析。结果 经上述方法分别治疗16天和30天后(平均23天),2例病人伤口均无分泌物,无红、肿、热、痛等炎症表现,溃疡创面及坏死创面结痂脱落,窦道均闭合。结论藏红高渗盐水治疗外科难治性伤口,效果显著,副作用少,患者经济负担减少。

关键词:藏红花、高渗盐水、难治性伤口