Yingying Meng1,2, Wali Lukman Ahmed3, Jian Luo4*

1 Medical School of Yangtze University, Jinzhou, China

2 Department of Gastroenterology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

3 Xuzhou Medical University, Xuzhou, China

4 Nursing Department, Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China

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How to cite this paper: Meng, Y.Y., Ahmed,W.L. and Luo, J. (2020) Application of Negative Pressure Manual Dressing Change Combined with Mupirocin Ointment in the Treatment of a Case of a Patient with Cirrhosis Complicated with Deep Thigh Abscess. Journal of Biosciences and Medicines, 8, 113-121. https://doi.org/10.4236/jbm.2020.85011

Received: March 13, 2020

Accepted: May 5, 2020

Published: May 8, 2020

Copyright © 2020 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

Abstract

Objective: To explore the treatment and nursing characteristics for pressure injury on the inside of the thigh caused by forced posture in patients with cirrhosis and diabetes mellitus.

Methods: A patient with cirrhosis and diabetes mellitus complicated with abscess of right inner thigh pressure injury was selected as the study object, who was admitted to Xuzhou Medical University Hospital on June 29, 2019. The analysis of the clinical diagnosis, treatment and nursing process were applied to explore the prognosis of the patient with cirrhosis and diabetes mellitus complicated with deep abscess of the thigh.

Results: The traditional treatment including incision and drainage was not allowed, as the general treatment was not effective for the patients with cirrhosis and diabetes mellitus complicated with deep abscess in the inner thigh. After 8 days of negative pressure manual dressing change combined with mupirocin ointment treatment, the local skin condition returned to normal.

Conclusion: After literature search, it was found that the above-mentioned cirrhosis combined with diabetes and deep abscess cases in the inner thigh were rare clinically. When the traditional treatment of incision and drainage is limited, negative pressure manual dressing change combined with antibiotics is an effective method, which is worthy of clinical application and promotion.

Keywords

Cirrhosis, Diabetes Mellitus, Pressure Injury, Deep Tissue Abscess, Negative Pressure Dressing Change

敏1* ，刘倩倩2 ，王 茹3# ，袁雅倩1

1 武汉科技大学医学院，湖北 武汉

2 三峡大学第三临床医学院国药葛洲坝中心医院心血管内科，湖北 宜昌

3 武汉科技大学附属华润武钢总医院老年病科，湖北 武汉

收稿日期：2022年1月21日；录用日期：2022年2月11日；发布日期：2022年2月24日

摘 要

随着人们年龄的增长，不可避免地出现机体各项生理功能下降，慢性病发生率上升，逐渐走向衰弱，直至生命终结。机体衰弱和糖尿病通常同时出现在某些老年人，且有部分共同的发病机制和危险因素。这篇文章旨在综述近年来对两种病理情况的新认识，描述它们的相互关系研究和治疗策略进展。

关键词

老年化，糖尿病，衰弱，发病机制，相互关系

文章引用: 曾敏, 刘倩倩, 王茹, 袁雅倩. 老年糖尿病患者合并衰弱综合征的研究现状[J]. 临床医学进展, 2022, 12(2):

1366-1373. DOI: 10.12677/acm.2022.122198

Research Status of the Elderly Diabetic Patients with Debilitating Syndrome

Min Zeng1*, Qianqian Liu2, Ru Wang3#, Yaqian Yuan1

1 Medical College, Wuhan University of Science and Technology, Wuhan Hubei

2 Department of Cardiovascular Medicine, Sinopharm Gezhouba Central Hospital, The Third Clinical Medical College of China Three Gorges University, Yichang Hubei

3 Department of Geriatrics, China Resources & WISCO General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan Hubei

Received: Jan. 21st, 2022; accepted: Feb. 11th, 2022; published: Feb. 24th, 2022

Abstract

With the growth of people’s age, it is inevitable that the physiological function of the body declines,and the incidence of chronic diseases increases, and gradually weakened, until the end of life. Frailty and diabetes mellitus usually occur simultaneously in some elderly people, and share some common pathogenesis and risk factors. This article aims to review new insights into two pathological conditions in recent years and describe their interrelationship research and advances in therapeutic strategies.

Keywords

Aging, Diabetes Mellitus, Frailty, Pathogenesis, Relationship

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

代丽霞1* ，陈新田1 ，李振江2 ，朱燕亭2#

1 西安医学院，陕西 西安

2 陕西省人民医院肾病血透中心，陕西 西安

收稿日期：2021年12月28日；录用日期：2022年1月18日；发布日期：2022年1月29日

摘 要

糖尿病肾病是糖尿病重要的微血管并发症，引起持续进展的慢性肾脏损害，导致肾功能衰竭。糖尿病肾病作为慢性肾病患者主要病因及死亡原因，极大地加重了全球健康及经济负担。糖尿病肾病发病机制较为复杂，现有治疗方案效果有限，亟待进一步探索发病机制，以更好地预防、治疗、管理糖尿病肾病。长链非编码RNA参与了许多生理过程，如细胞周期调节、细胞凋亡和存活、肿瘤迁移和代谢等。某些LncRNAs在糖尿病肾病发病机制中发挥重要作用。本文综述了参与糖尿病肾病发病机制、作为生物标志物或在临床应用中作为治疗靶点的LncRNAs。

关键词

糖尿病肾病，LncRNAs，生物标志物，治疗靶点

Progress in the Function and Significance of LncRNAs in Diabetic Nephropathy Lixia Dai1*, Xintian Chen1, Zhenjiang Li2, Yanting Zhu2#

1 Xi’an Medical University, Xi’an Shaanxi

2 Kidney Disease Hemodialysis Center of Shaanxi Provincial People’s Hospital, Xi’an Shaanxi

Received: Dec. 28th, 2021; accepted: Jan. 18th, 2022; published: Jan. 29th, 2022

Abstract

      Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus, leading to gradual progress in chronic deterioration of renal function, eventually resulting in the occurrence of kidney failure. DN is the major cause of the high morbidity and mortality of chronic kidney disease (CKD), which significantly aggravates the healthy and economic burden globally. Therefore, it is important to explore the underlying mechanism for prevention and management of DN due to the complicated pathogenesis and limited therapy. Long noncoding RNA (LncRNA), a novel target, is involved in many physiological processes, such as cell cycle regulation, apoptosis, cell survival, tumor migration and metabolism. Furthermore, evidence suggests that LncRNAs play a vital role in DN pathogenesis. This review summarizes LncRNAs, which are involved in the pathogenesis of DN, and used as biomarkers or therapeutic targets of DN in clinical practice.

Keywords

Diabetic Nephropathy, LncRNAs, Biomarkers, Therapeutic Targets

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

侯显玥，杜柯锐，杨小娟*

延安大学附属医院肾内科，陕西 延安

收稿日期：2022年6月1日；录用日期：2022年6月24日；发布日期：2022年7月4日

摘 要

随着对糖尿病肾病(DKD)研究的不断深入，慢性炎症状态的地位越来越凸显。近年来，一种与天冬氨酸半胱氨酸蛋白水解酶(Caspase)-1相关的程序性细胞死亡机制，通过足细胞与肾小管上皮细胞的焦亡引起一系列炎症反应，最终导致肾功能恶化。肠道菌群异常在慢性肾脏病患者中致病证据越来越充分，其机制表现为菌群比例的失调(有害细菌增多、有益菌减少甚至缺如)，产生炎症因子及氧化应激产物。另外，内脂素(Visfatin)在DKD发生发展中均发挥作用，参与胰岛素抵抗、调控糖脂代谢、增强炎症反应等过程。同样，适应性免疫系统及相关细胞因子同样有重要作用，通过T细胞、B细胞及白细胞介素(interleukin,IL)-17A、白细胞介素(interleukin, IL)-2、肿瘤坏死因子(TNF)和肿瘤坏死因子(TNF)受体等细胞因子共同导致蛋白尿的产生、肾功能的恶化。因此，了解诱导慢性炎症的各类分子机制在糖尿病肾病发生以及发展中的作用，对糖尿病肾病的早期识别及治疗有重要意义。

关键词

糖尿病肾病，炎症，细胞焦亡，肠道菌群，内脂素，适应性免疫

Progress in the Study of Chronic Inflammatory Mechanism of Diabetic Nephropathy Xianyue Hou, Kerui Du, Xiaojuan Yang*

Department of Nephrology, Affiliated Hospital of Yan’an University, Yan’an Shaanxi Received: Jun. 1st, 2022; accepted: Jun. 24th, 2022; published: Jul. 4th, 2022

Abstract

With the continuous deepening of the study of Diabetic Kidney Disease (DKD), the status of chron-ic inflammation is becoming more and more prominent. In recent years, a programming cell death mechanism related to cyspase-1 is caused by the scorching of foot cells and renal tubular epithelial cells, which causes a series of inflammatory reactions and eventually leads to kidney function worsen. The inferior of the intestinal flora is increasingly sufficient in patients with chronic kidney disease, and its mechanism is manifested as the disorders of the flora ratio (increasing harmful bacteria, reduced beneficial bacteria, or even lack of), producing inflammatory factor and oxidation stimulating products. In addition, Visfatin played a role in the development of DKD to participate in the process of participating in insulin resistance, regulating sugar fat metabolism, and enhancing inflammatory response. Similarly, the adaptive immune system and related cytokine also have an important role, T cells, B cells and cytokines such as interleukin (IL)-17A, interleukin (IL)-2, tumor necrosis factor (TNF) and tumor necrosis factor (TNF) receptor jointly lead to the production of proteinuria and the deterioration of renal function. Therefore, understanding the role of various types of molecular mechanisms that induce chronic inflammation in the occurrence and development of diabetic nephropathy is of great significance for the early identification and treatment of diabetic nephropathy.

Keywords

Diabetic Kidney Disease, Inflammation, Pyroptosis, Gut Microbiota, Visfatin, Adaptive Immunity

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/