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Ehab Mohammed1, Issa Al Salmi1,2* , Dawood Al Riyami3, Saif Khan3, Marwa Al Riyami4, Fatma Al Rahbi1, Suad Hannawi5
1 The Renal Medicine Department, The Royal Hospital, Muscat, Oman
2 The Medicine Department, Oman Medical Specialty Board, Muscat, Oman
3 The Renal Medicine Department, SQUH, Muscat, Oman
4 The Pathology Department, SQUH, Muscat, Oman
5 The Medicine Department, MOHAP, Dubai, UAE
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How to cite this paper: Mohammed, E., Al Salmi, I., Al Riyami, D., Khan, S., Al Riyami, M., Al Rahbi, F. and Hannawi, S. (2022) Non-Diabetic Kidney Disease in Type 2 Diabetes Mellitus: A Study of 82 Patients and Review of the Literatures. Open Journal of Nephrology, 12, 169-186. https://doi.org/10.4236/ojneph.2022.121017
Received: February 25, 2022
Accepted: March 25, 2022
Published: March 28, 2022
Copyright © 2022 by author(s) and Scientific Research Publishing Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/
Abstract
Background: Worldwide, diabetic nephropathy-DN is the leading cause of end-stage kidney disease-ESKD, DN is a common cause of renal failure with a reported frequency of 10% - 15% in type-2-diabetes-mellitus-T2DM patients, however there is a great discrepancy between countries. The aim of the present study is to evaluate the findings of kidney biopsies performed on diabetic patients.
Materials and Methods: We studied native kidney histopathological findings in the period from January 2016 till end of December 2018 done for patients with T2DM with chronic kidney diseases-CKD.
Results: A total of 82 DM-patients, 50 males (61%) and 32 females (39%) with age mean (95% CI) of 50.8 (47.1 - 55.2) years for all patients, ranged between 15 to 65 years. Histological findings showed that 57.3% of patients had DN. While focal-segmental-glomerulosclerosis-FSGS was present in 20.7%—primary in 8.6% and secondary in 12.1%. IgA represented 4.9%, while Lupus nephritis, Membranous and drug induced interstitial nephritis were each present in 3.7%. MCD was present in 2.4%. Lastly diffuse proliferative GN, ANCA associated glomerulonephritis, and hypertensive nephrosclerosis accounted for 1.2%.
Conclusion: The prevalence of NDKD is remarkably frequent in DM patients who underwent kidney biopsy and FSGS was the most frequent diagnosis. To get a proper histopathological diagnosis, an adequate tissue biopsy is needed with an adequate number of glomeruli. There is a great need for more consideration to biopsy diabetic patients, as the finding of NDKD requires a different therapeutic approach. This, hopefully, will help to manage these patients better and therefore, ameliorate the progression to ESKD over time and therefore delay the need for RRT.
Keywords
Diabetic Nephropathy, Diabetic Kidney Disease, Histopathology, Light Microscopy, Electron Microscopy, Immunofluorescence, Non-Diabetic Kidney Diseases, Renal Replacement Therapy (RRT)
Fu-Lei Li1 | Gao-Chao Wang2 | Bu-Qiang Wu1
1 Department of General Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China
2 Changzhi Medical College, Changzhi, China
Correspondence
Bu-Qiang Wu, MD, Department of General Surgery, Heping Hospital Affiliated to Changzhi Medical College, No. 110, Yan'an South Road, Changzhi, 046000, Shanxi Province, China. Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Abstract
This study aimed to explore the clinical application and efficacy of traditional Chinese medicine (TCM) powder in the treatment of acute and chronic wounds. Eighty patients with a wound infection were randomly and equally divided into a control group and an observation group. Gauze padding containing furacilin was used to dress the infected wounds of the control group. TCM powder was used to treat the wounds of the observation group. The total response rate of the observation group was significantly higher than the control group (P = .017). The colour and exudate volume scores in the observation group were lower than the control group, and the differences between the two groups were statistically significant (P < .05). The time to the appearance of new epithelium and time to the wound healing of the burns in the observation group were shorter than the control group, and the differences were statistically significant (P < .05). The TCM powder absorbed a large amount of necrotic tissue and exudate from the wound surface, cleared heat and toxins, and activated blood circulation. It also resolved blood stasis, eliminated pus, and allowed for new skin growth, as well as regenerating muscle.
KEYWORDS ：burn depth, burns, scalds, traditional Chinese medicine powder, wound surface
Key Messages
- the use of traditional Chinese medicine powder has certain advantages over the conventional Western medicine treatment of wounds as it is noninvasive and relatively cheap
- it has been shown to heal all types of burns, including third-degree burns, and is effective for treating ulcers, such as those found in diabetic foot
- it has also been successful in healing wounds that conventional treatment could not
Yu Zhu1,2*, Qingqing Liu1*, Yurong Zhu1*, Tiantian Guo1, Mengtong Jin1, Jiali Hao1, Chao Qi1, Xiaofeng Miao1, Duan Xi1, Jiamao Fan1#, Jin Li2
1 Linfen Central Hospital, Linfen, China
2 Beijing Sport University, Beijing, China
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How to cite this paper: Zhu, Y., Liu, Q.Q.,Zhu, Y.R., Guo, T.T., Jin, M.T., Hao, J.L.,Qi, C., Miao, X.F., Xi, D., Fan, J.M. and Li, J. (2022) Effects of Common Myokines on Diabetes Mellitus. Journal of Diabetes Mellitus, 12, 153-166. https://doi.org/10.4236/jdm.2022.123013
Received: February 17, 2022
Accepted: June 14, 2022
Published: June 17, 2022
Copyright © 2022 by author(s) and Scientific Research Publishing Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/
Abstract
Diabetes mellitus, a type of chronic metabolic disease, is occurring more frequently and causes severe threats to human health. In vivo, exercise can stimulate skeletal muscle cells to secrete and release myokines into blood circulation, which will participate in metabolism and act on multiple organs or systems. Recently, the relationship between myokines and diabetes mellitus was a hot research topic, and myokines may be potential targets for the diagnosis, monitoring, prevention and treatment of diabetes mellitus. In this review, we elucidated the multiple effects of common myokines in the pathogenesis and therapy of diabetes mellitus, which will provide a theoretical foundation of the mechanism in the positive effects of exercises on humans.
Keywords: Diabetes, Myokines, Islet Cells, Insulin Resistance
Anna Papadopoulou*, Petros Karkalousos, Maria Trapali
Laboratory of Chemistry, Biochemistry, Cosmetic Science, University of West Attica, Athens, Greece
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How to cite this paper: Papadopoulou, A., Karkalousos, P. and Trapali, M. (2022) Effects of Diabetes Mellitus upon Sperm Quality Insight into Molecular Level. Journal of Diabetes Mellitus, 12, 75-86.
https://doi.org/10.4236/jdm.2022.122008
Received: January 10, 2022
Accepted: April 16, 2022
Published: April 19, 2022
Copyright © 2022 by author(s) and Scientific Research Publishing Inc.
This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).
http://creativecommons.org/licenses/by/4.0/
Abstract
Diabetes Mellitus is a chronic disease that affects important body organs in a very serious manner. The consequences of this disease turn out to be a significant problem for the patient, who tries to cope with the new condition his organism has been placed in. The most common effect of the disease, hyperglycaemia, leads over time to serious damage to various body systems, such as nerves and blood vessels. What is not widely known among the population is that diabetes may have harmful effects on the reproductive system of the men suffering from diabetes type 1 and 2 and that such a parameter could lead to or might be the reason for infertility problems for couples, for example, miscarriage or embryonic failure. AGEs is a number of products which are believed to play an important role, because their presence has been detected in increased level in diabetic men. This implies that those glycation products might play a key role in diabetic complications. Their receptor, RAGE, member of the immunoglobulin superfamily has been detected in the reproductive tract of diabetic men. Reactive oxygen species (ROS), a possible product of AGEs appear in high levels in seminal plasma and are believed to be the cause of DNA fragmentation. The objective of this review was to gather all the available material i.e. studies on diabetes mellitus in one article, to study the research which has already been conducted and the conclusions that have been drawn, in order to offer, if possible, new pathways and perspectives to the scientists, who focus on fertility problems, sometimes intractable.
Keywords
Diabetes, Nuclear Fragmentation, Sperm Quality, ROS, Sperm Motility, Sertoli Cells, RAGE, Sperm Structure, Gene Expression
