代丽霞1* ，陈新田1 ，李振江2 ，朱燕亭2#

1 西安医学院，陕西 西安

2 陕西省人民医院肾病血透中心，陕西 西安

收稿日期：2021年12月28日；录用日期：2022年1月18日；发布日期：2022年1月29日

摘 要

糖尿病肾病是糖尿病重要的微血管并发症，引起持续进展的慢性肾脏损害，导致肾功能衰竭。糖尿病肾病作为慢性肾病患者主要病因及死亡原因，极大地加重了全球健康及经济负担。糖尿病肾病发病机制较为复杂，现有治疗方案效果有限，亟待进一步探索发病机制，以更好地预防、治疗、管理糖尿病肾病。长链非编码RNA参与了许多生理过程，如细胞周期调节、细胞凋亡和存活、肿瘤迁移和代谢等。某些LncRNAs在糖尿病肾病发病机制中发挥重要作用。本文综述了参与糖尿病肾病发病机制、作为生物标志物或在临床应用中作为治疗靶点的LncRNAs。

关键词

糖尿病肾病，LncRNAs，生物标志物，治疗靶点

Progress in the Function and Significance of LncRNAs in Diabetic Nephropathy Lixia Dai1*, Xintian Chen1, Zhenjiang Li2, Yanting Zhu2#

1 Xi’an Medical University, Xi’an Shaanxi

2 Kidney Disease Hemodialysis Center of Shaanxi Provincial People’s Hospital, Xi’an Shaanxi

Received: Dec. 28th, 2021; accepted: Jan. 18th, 2022; published: Jan. 29th, 2022

Abstract

      Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus, leading to gradual progress in chronic deterioration of renal function, eventually resulting in the occurrence of kidney failure. DN is the major cause of the high morbidity and mortality of chronic kidney disease (CKD), which significantly aggravates the healthy and economic burden globally. Therefore, it is important to explore the underlying mechanism for prevention and management of DN due to the complicated pathogenesis and limited therapy. Long noncoding RNA (LncRNA), a novel target, is involved in many physiological processes, such as cell cycle regulation, apoptosis, cell survival, tumor migration and metabolism. Furthermore, evidence suggests that LncRNAs play a vital role in DN pathogenesis. This review summarizes LncRNAs, which are involved in the pathogenesis of DN, and used as biomarkers or therapeutic targets of DN in clinical practice.

Keywords

Diabetic Nephropathy, LncRNAs, Biomarkers, Therapeutic Targets

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

侯显玥，杜柯锐，杨小娟*

延安大学附属医院肾内科，陕西 延安

收稿日期：2022年6月1日；录用日期：2022年6月24日；发布日期：2022年7月4日

摘 要

随着对糖尿病肾病(DKD)研究的不断深入，慢性炎症状态的地位越来越凸显。近年来，一种与天冬氨酸半胱氨酸蛋白水解酶(Caspase)-1相关的程序性细胞死亡机制，通过足细胞与肾小管上皮细胞的焦亡引起一系列炎症反应，最终导致肾功能恶化。肠道菌群异常在慢性肾脏病患者中致病证据越来越充分，其机制表现为菌群比例的失调(有害细菌增多、有益菌减少甚至缺如)，产生炎症因子及氧化应激产物。另外，内脂素(Visfatin)在DKD发生发展中均发挥作用，参与胰岛素抵抗、调控糖脂代谢、增强炎症反应等过程。同样，适应性免疫系统及相关细胞因子同样有重要作用，通过T细胞、B细胞及白细胞介素(interleukin,IL)-17A、白细胞介素(interleukin, IL)-2、肿瘤坏死因子(TNF)和肿瘤坏死因子(TNF)受体等细胞因子共同导致蛋白尿的产生、肾功能的恶化。因此，了解诱导慢性炎症的各类分子机制在糖尿病肾病发生以及发展中的作用，对糖尿病肾病的早期识别及治疗有重要意义。

关键词

糖尿病肾病，炎症，细胞焦亡，肠道菌群，内脂素，适应性免疫

Progress in the Study of Chronic Inflammatory Mechanism of Diabetic Nephropathy Xianyue Hou, Kerui Du, Xiaojuan Yang*

Department of Nephrology, Affiliated Hospital of Yan’an University, Yan’an Shaanxi Received: Jun. 1st, 2022; accepted: Jun. 24th, 2022; published: Jul. 4th, 2022

Abstract

With the continuous deepening of the study of Diabetic Kidney Disease (DKD), the status of chron-ic inflammation is becoming more and more prominent. In recent years, a programming cell death mechanism related to cyspase-1 is caused by the scorching of foot cells and renal tubular epithelial cells, which causes a series of inflammatory reactions and eventually leads to kidney function worsen. The inferior of the intestinal flora is increasingly sufficient in patients with chronic kidney disease, and its mechanism is manifested as the disorders of the flora ratio (increasing harmful bacteria, reduced beneficial bacteria, or even lack of), producing inflammatory factor and oxidation stimulating products. In addition, Visfatin played a role in the development of DKD to participate in the process of participating in insulin resistance, regulating sugar fat metabolism, and enhancing inflammatory response. Similarly, the adaptive immune system and related cytokine also have an important role, T cells, B cells and cytokines such as interleukin (IL)-17A, interleukin (IL)-2, tumor necrosis factor (TNF) and tumor necrosis factor (TNF) receptor jointly lead to the production of proteinuria and the deterioration of renal function. Therefore, understanding the role of various types of molecular mechanisms that induce chronic inflammation in the occurrence and development of diabetic nephropathy is of great significance for the early identification and treatment of diabetic nephropathy.

Keywords

Diabetic Kidney Disease, Inflammation, Pyroptosis, Gut Microbiota, Visfatin, Adaptive Immunity

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

http://creativecommons.org/licenses/by/4.0/

许洋洋* ，陈树荣，田章萍，蔡晓燕，李 慧

盐城市亭湖区人民医院，江苏 盐城

收稿日期：2022年3月26日；录用日期：2022年4月21日；发布日期：2022年4月28日

摘 要

目的：研究VSD负压引流联合纳米银敷料在3、4期压力性损伤感染创面中的应用效果，为3、4期压力性损伤感染创面的患者制定合理的护理方案、评价护理效果提供依据。方法：选取2019年3月~2021年3月一年时间中，在我院就诊的3、4期压力性损伤患者320例，并将其平均分为两组，即观察组与对照组。前者采用的治疗方式为VSD负压引流技术联合纳米银离子敷料；后者使用VSD负压引流技术进行治疗。两组进行数据对比，对比的因素有临床治疗效果、换药次数与费用、创面愈合与肉芽组织生长时间。结果：观察组上述因素都明显低于对照组(P < 0.05)，其临床治疗有效率(86.88%)显著高于对照组(59.38%,P < 0.05)。结论：采用VSD负压引流技术联合银离子技术对3、4期压力性损伤患者进行治疗，可以减少换药次数以此来节省费用，同时患者所承受的疼痛也有很大程度降低，并且创面愈合速度更快，综上所述，其临床应用价值较高，值得进行推广。

关键词：VSD负压引流，纳米银敷料治疗，压力性损伤，促进创面愈合，临床治疗效果，应用对比研究

Comparative Application Study of VSD Negative Pressure Drainage Combined with Nano-Silver Dressing in the Treatment of Stage 3 and 4 Pressure Injuries

Yangyang Xu*, Shurong Chen, Zhangping Tian, Xiaoyan Cai, Hui Li

People’s Hospital of Tinghu District, Yancheng City, Yancheng Jiangsu

Received: Mar. 26th, 2022; accepted: Apr. 21st, 2022; published: Apr. 28th, 2022

文章引用: 许洋洋, 陈树荣, 田章萍, 蔡晓燕, 李慧. VSD 负压引流联合纳米银敷料治疗 3、4 期压力性损伤中的应用对比研究[J]. 临床医学进展, 2022, 12(4): 3529-3534. DOI: 10.12677/acm.2022.124512

Abstract

Objective: To study the application effect of VSD negative pressure drainage combined with nano-silver dressing in stage 3 and 4 pressure injury infected wounds, so as to provide basis for formulating reasonable nursing plan and evaluating nursing effect for patients with stage 3 and 4 pressure injury infected wounds. Methods: A total of 320 patients with stage 3 and 4 stress injury admitted to our hospital from March 2019 to March 2021 were randomly divided into observation group and control group, with 160 cases in each group. The control group was treated with VSD negative pressure drainage, and the observation group was treated with VSD negative pressure drainage combined with nano-silver ion dressing. Pain degree, dressing change times, dressing change cost, wound healing time, granulation tissue growth time and clinical treatment effect were compared between the two groups. Results: The number of dressing change, cost of dressing change, wound healing time, pain degree and granulation tissue growth time in the observation group were significantly lower than those in the control group (P < 0.05). The clinical effective rate in the observation group (86.88%) was significantly higher than that in the control group (59.38%, P < 0.05). Conclusion: We use VSD negative pressure drainage technology to combine silver ion technology to treat patients with stress injuries 3 and 4, which can reduce the number of changes to save costs large extent, and the wound healing is faster, at the same time, the pain of the patient has been greatly reduced, and the wound healing is faster. In summary, its clinical application is worth promoting.

Keywords：VSD Negative Pressure Drainage, Nano-Silver Dressing Treatment, Pressure Injury, Promote Wound Healing, Clinical Treatment Effect, Comparative Application Study

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

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周 甜1,2，邵小娟1 ，杜小东1,2，马卫国1 ，李 亚1*

1 西安医学院第一附属医院内分泌科，陕西 西安

2 西安医学院研究生院，陕西 西安

收稿日期：2022年4月27日；录用日期：2022年5月21日；发布日期：2022年5月30日

摘 要

本文报道2021年09月29日西安医学院第一附属医院内分泌科收治的1例62岁男性2型糖尿病足合并反复发热患者的诊疗过程。经过积极检查及诊疗临床诊断为糖尿病足合并类风湿性关节炎，且给予降温、抗感染、局部清创换药等治疗后，患足创面愈合良好。启示：临床上糖尿病足伴发热的原因主要为感染性疾病，但不局限于感染性疾病，自身免疫性疾病不易忽略，尤其在使用糖皮质激素治疗时。

关键词：糖尿病足，类风湿性关节炎，发热

A Case Report of Diabetic Foot Complicated with Rheumatoid Arthritis Tian Zhou1,2, Xiaojuan Shao1, Xiaodong Du1,2, Weiguo Ma1, Ya Li1*

1 Department of Endocrinology, The First Affiliated Hospital of Xi’an Medical College, Xi’an Shaanxi

2 Graduate School of Xi’an Medical College, Xi’an Shaanxi

Received: Apr. 27th, 2022; accepted: May 21st , 2022; published: May 30th, 2022

Abstract

This article reported on the diagnosis and treatment of a 62-year-old male patient with type 2 diabetic foot complicated with recurrent fever admitted to the Department of Endocrinology of the First Affiliated Hospital of Xi’an Medical University on September 29, 2021. After positive examination and diagnosis and treatment, the patient was clinically diagnosed as diabetic foot compli-cated with rheumatoid arthritis. After cooling, anti-infection, local debridement and dressing change, the wound healed well. Revelation: Clinically, diabetic foot with fever is mainly caused by infectious diseases, but not limited to infectious diseases. Autoimmune diseases are not easy to be ignored, especially when glucocorticoids are used for treatment.

Keywords：Diabetic Foot, Rheumatoid Arthritis, Fever

Copyright © 2022 by author(s) and Hans Publishers Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY 4.0).

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