伤口世界

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星期一, 12 7月 2021

王贵强

教授，主任医师，博士研究生导师

中央保健会诊专家

北京大学第一医院感染疾病科主任，兼任肝病中心主任

中华医学会感染病学分会前任主任委员

中国医院协会抗菌药物合理应用工作委员会主任委员

中国医师协会感染病医师分会副会长

中华医学会全科医师教育学院副院长

国家免疫规划专家咨询委员会委员

国家卫健委传染病标准委员会委员

国务院应对新冠肺炎联防联控机制医疗救治专家组成员

国家卫健委新冠病毒肺炎恢复期血浆治疗专家组成员

国家卫健委境外抗疫医疗专家组国家顾问团成员

国务院应对新冠肺炎联防联控机制科研攻关专家组成员

科技部新冠肺炎国际合作专家组成员

美国《临床感染病》杂志编委，《中华传染病杂志》和《中华临床感染病杂志》副总编辑，《临床肝胆病学》共同主编等。

星期一, 12 7月 2021

冉兴无

主任医师，教授，博士研究生导师

四川大学华西医院内分泌代谢科副主任

四川大学华西医院糖尿病足诊治中心主任

四川大学华西医院血管中心糖尿病周围血管病变分中心主任

四川省卫生厅学术技术带头人

四川省学术技术带头人

四川省卫生计生委领军人才

中华医学会糖尿病分会常务委员

中华预防医学会组织感染与损伤预防与控制专业委员会副主任委员

中国医师协会内科培训专业指导委员会副主任委员

中华医学会糖尿病分会糖尿病足病工作组组长

西部精神医学协会内分泌暨糖尿病专业委员会主任委员

四川省医学会内分泌暨糖尿病专业委员会主任委员

四川省医学会糖尿病周围血管病变暨足病学组组长

四川省医学会内科专业委员会常务委员兼代谢病学组组长

四川省医师协会内分泌代谢专科医师专业委员会副主任委员。

星期一, 12 7月 2021

一文读懂：清创在伤口愈合中的重要作用

清创（Debridement）用于去除伤口中的坏死组织或异物。清创的方法很多，不同方法的定义和适应症不同。有些方法可能在某些情况下仍不被认同。外科和保守的锐器清创由于需要使用外科器械而被认为是有创方法。医疗人员应该遵循各自（医生、护士、专科护士和医生助理等）行医执业范围和机构的规定进行临床实践。

星期一, 12 7月 2021

Cell子刊揭示细菌可促进皮肤伤口愈合和毛囊新生

星期一, 12 7月 2021

感染伤口的微生物学评估

一、伤口的特征

伤口是破坏皮肤完整性和保护功能的损伤。急性伤口一般由外部损伤导致，包括擦伤、小的割伤、撕裂伤、刺伤、咬伤、烧伤（热、冷、摩擦、化学品）和外科手术切口。如果伤口在三个月内没有能够愈合（即恢复解剖和功能完整性），则被定义为慢性伤口【 1】（注：关于慢性伤口的定义在不断发展，目前逐渐不拘泥于时限，而更加重视影响伤口愈合的病因）。最常见的慢性伤口类型是压力性溃疡、下肢静脉溃疡和糖尿病足溃疡。

星期一, 12 7月 2021

感染伤口的微生物学评估

识别和管理伤口感染是一线医疗实践的重要任务。然而，有关伤口感染病因和采样的很多问题仍然存有争议，缺乏共识。很多伤口感染能够得到临床诊断，而实验室检查的结果提供进一步信息来指导治疗。只有当伤口存在临床感染表现和伤口在恶化、增大或不能愈合时才有必要进行(拭子)培养。对没有感染的伤口进行拭子采集会产生不必要的微生物识别和分析，而所发现的微生物可能仅定植于伤口,而非引起感染。

K2 Content

Betaine–salicylic acid cocrystal for enhanced skincare and acne treatment† 2025-04-03 00:00

Zhenyuan Wang,ab Mi Wang, *a Qingsheng Tao,c Yufei Li, d Hao Wang,a Mei Zhang,c Xueli Liuc and Jiaheng Zhang *a

a Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China. E-mail: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

b Shenzhen Shinehigh Innovation Technology Co., Ltd., Shenzhen 518055, China

c Advanced Research, L'Oreal Research & Innovation China, Shanghai 201206, China

d The Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China

† Electronic supplementary information (ESI) available. CCDC 2101906. For ESI

and crystallographic data in CIF or other electronic format see DOI: https://doi.

org/10.1039/d5md00001g

Salicylic acid (SA) is a natural lipophilic active ingredient commonly used in cosmetics and skin disease treatments, offering benefits such as exfoliation, anti-inflammation effects, antibacterial properties, oil control, and acne alleviation. However, its poor water solubility, low bioavailability, and potential side effects, such as allergies, irritation, and dryness, hinder its widespread application. In this study, we prepared a betaine–salicylic acid (BeSA) cocrystal and systematically characterized its crystal structure, biological activity, and clinical efficacy. The results showed that BeSA has significantly lower irritancy and cytotoxicity than SA, but exhibits excellent anti-inflammatory and antioxidant properties as well as high moisturizing and anti-acne efficacy, making it a potential alternative to SA. Further, quantum chemical calculations and molecular docking simulations were conducted to investigate the intrinsic mechanisms underlying the excellent bioactivity of BeSA cocrystals. This study introduces an innovative solution for safer and more effective skincare formulations based on SA and offers theoretical guidance regarding material engineering and further material optimization, which has crucial implications for both industry and academia.

Received 1st January 2025,

Accepted 4th February 2025

DOI: 10.1039/d5md00001g rsc.li/medchem
Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes: Rationale and design of a two-armed double blind randomized controlled trial 2025-04-02 00:00

Anna Ericsson a,* , Karin Borgstrom¨ b,c , Christine Kumlien a,c,d , Magdalena Gershater Annersten a,c , Tautgirdas Ruzgas b,c , Johan Engblom b,c , Petri Gudmundsson b,c , Victoria Lazer a , Skaidre Jankovskaja b,c , Eva Lavant b,c , Sophia Ågren-Witteschus d , Sebastian Bjorklund ¨ b,d , Saman Salim e,f , Mikael Åstrom¨ g , Stefan Acosta f

a Department of Care Science, Faculty of Health and Society, Malm¨ o University, Malm¨ o, Sweden

b Department of Biomedical Science, Faculty of Health and Society, Malm¨ o University, Malm¨ o, Sweden

c Biofilms – Research Center for Biointerfaces, Malm¨ o University, Malm¨ o, Sweden

d Department of Cardiothoracic and Vascular Surgery, Skåne University Hospital, Malm¨ o, Sweden

e Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark

f Department of Clinical Sciences, Lund University, Malmo, ¨ Sweden

g StatCons, Sweden

ARTICLE INFO

Keywords: Diabetes mellitus Dry feet Prevention Foot-xerosis Self-care

ABSTRACT

Introduction: To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without footulcers using two skincare creams containing different humectants (interventions) against a cream base nonhumectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, lowmolecular weight biomarkers and skin microbiota, microcirculation including transcutaneous oxygen pressure, degree of neuropathy, and HbA1c between intervention-comparator creams.

Methods: Two-armed double-blind RCT, registered in ClinicalTrials.gov Identifier: NCT06427889. With 80 % power, two-tailed significance of 2.5 % in each arm, 39 study persons is needed in each arm, total 78 persons, 98 including dropouts, to be able to prove a reduction of at least one category in the Xerosis Severity Scale with the intervention creams compared to the comparator. In one arm, each participant will treat one foot with one of the intervention creams (Oviderm® or Canoderm®), while the opposite foot will be treated with the comparator cream (Decubal®lipid cream), twice a day. If needed, participants are enrolled after a wash-out period of two weeks. The participants will undergo examinations at baseline, day 14 and day 28.

Discussion: This RCT evaluate the potential effects of humectants in skin creams against foot xerosis in persons with diabetes.
Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles 2025-04-01 00:00

Ha Young Park a , Min Ho Kang a , Guewha Lee b , Jin Woo Kim a,c,*

a Department of Food Science, Sunmoon University, Chungcheongnam-do, Republic of Korea

b Hu evergreen Pharm Inc., Incheon, Republic of Korea

c Center for Next-Generation Semiconductor Technology, Sun Moon University, Chungnam, Republic of Korea

ARTICLE INFO

Keywords: Ginseng non-edible callus Extracellular vesicle Skin regeneration Collagen synthesis Proliferation

1 . ABSTRACT

Background: This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF).

Methods: GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis (TGF-β, SMAD-2, SMAD-3, COL1A1) was measured using RT-PCR.

Results: Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically TGF-β, SMAD-2, SMAD-3, and COL1A1, by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the TGF-β/SMAD signaling pathway, showcasing its potential to induce skin

Conclusions: In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the TGF-β/SMAD signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

王贵强

冉兴无

一文读懂：清创在伤口愈合中的重要作用

Cell子刊揭示细菌可促进皮肤伤口愈合和毛囊新生

感染伤口的微生物学评估

感染伤口的微生物学评估

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

王贵强

冉兴无

一文读懂：清创在伤口愈合中的重要作用

Cell子刊揭示细菌可促进皮肤伤口愈合和毛囊新生

感染伤口的微生物学评估

感染伤口的微生物学评估

消息订阅

学术会议

伤口世界提示