戴申，鹿颜，余鹏辉，龚雨顺*，刘仲华*

湖南农业大学园艺园林学院，国家植物功能成分利用工程技术研究中心，茶学教育部重点实验室，湖南 长沙 410128

摘要：综述了茶叶及其主要功能成分茶多酚、茶氨酸和咖啡碱对秀丽线虫、果蝇及老鼠等多种模式生物的抗衰老作用；概述了茶叶预防衰老相关疾病的保健功能；阐述了茶叶通过调节能量感应网络延缓衰老的研究现状；简单讨论了今后茶叶抗衰老研究的方向。

关键词：茶；抗衰老；能量感应网络

中图分类号：S571.1 文献标识码：A 文章编号：1000-369X(2019)01-023-11

Research Progress of The Preventing Effects of Tea on Aging and Aged-related Pathologies

DAI Shen, LU Yan, YU Penghui, GONG Yushun*, LIU Zhonghua*

Hunan Agriculture University, College of Horticulture and Landscape, National Engineering Center of Plant Functional Components Utilization, Key Lab of Tea Science, Changsha 410128, China

Abstract: In this paper, the anti-aging effects of tea in model organisms such as Caenorhabditis elegans, Drosophila flies and mice were reviewed. The main functional components (tea polyphenols, theanine and caffeine) were especially emphasized. The beneficial functions of tea in preventing age-related diseases were summarized. Furthermore, the latest research on its mechanism of regulating the nutrient-sensing signaling networks was expounded. Finally, the future research direction was briefly discussed.

Keywords: tea, anti-aging, nutrient-sensing signaling networks

收稿日期：2018-08-27 修订日期：2018-09-20

基金项目：湖南省自然科学基金（No. 2018JJ2161）

作者简介：戴申，女，硕士研究生，主要从事茶叶功能成分化学研究。*通信作者：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。，该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Pam Brown

GP in Swansea

Citation: Brown P (2024) Diabetes Distilled: Diabetes remission in the real world. Diabetes & Primary Care 26: 145–7

      Diabetes remission is achievable at scale in the real world, according to early results from the NHS Type 2 Diabetes Path to Remission programme published in Lancet Diabetes & Endocrinology. Of 7540 people referred to the programme between September 2020 and December 2022, a total of 1740 started the total diet replacement section of the programme before January 2022, and 960 (55%) completed the programme. Mean weight loss for the 1710 who started the programme and had follow-up data available was 9.4 kg (8.3%), with a mean weight loss of 10.3 kg (9.3%) among the 945 who completed the programme. Amongst the 945 who completed the programme and had two HbA1c measurements, 32% achieved remission, with mean weight loss of 15.9 kg (14.4%), while overall 27% of those who started the programme achieved remission regardless of whether they completed. Remission rates are lower than in trials such as DiRECT and DIADEM-I, despite similar levels of weight loss. The authors highlight that an additional 17% of participants met the HbA1c targets for remission but continued on metformin and may otherwise have achieved remission. These early results confirm that type 2 diabetes remission is indeed possible at scale in the real world, outside of clinical trials.

  Pam Brown GP in Swansea

Citation: Brown P (2024) Diabetes Distilled: Impact of metformin timing on glucose and GLP-1 response. Diabetes & Primary Care 26: 143–4

  Glucose-lowering effects in response to normal-release metformin are greater when the drug is given 30 or 60 minutes before, rather than with, food, according to this small study in people with well-controlled type 2 diabetes published in Diabetologia. Endogenous GLP-1 secretion increased when metformin 1000 mg was given 30 or 60 minutes prior to a glucose infusion, whereas there was no increase when the metformin was administered at the same time as the glucose. The results suggest that, if tolerated, administering standard release metformin before meals may lead to improved postprandial glycaemic control.