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Skin preparation for preventing infection following caesarean section

Diah R Hadiati¹, Mohammad Hakimi¹, Detty S Nurdiati ², Yuko Masuzawa³, Katharina da Silva Lopes ⁴, Erika Ota⁵

¹Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. ²Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia. ³Department of Health Informatics, Graduate

School of Medicine/School of Public Health, Kyoto University, Kyoto, Japan.⁴Graduate School of Public Health, St. Luke's International University, Tokyo, Japan. ⁵Global Health Nursing, Graduate School of Nursing Science, St. Luke's International University, Tokyo, Japan

Contact: Diah R Hadiati, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。.

Editorial group: Cochrane Pregnancy and Childbirth Group.

Publication status and date: New search for studies and content updated (no change to conclusions), published in Issue 6, 2020.

Citation: Hadiati DR, Hakimi M, Nurdiati DS, Masuzawa Y, da Silva Lopes K, Ota E. Skin preparation for preventing infection following caesarean section. Cochrane Database of Systematic Reviews 2020, Issue 6. Art. No.: CD007462. DOI: 10.1002/14651858.CD007462.pub5. Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention

Clare F Heal^1,2, Jennifer L Banks ³, Phoebe D Lepper ³, Evangelos Kontopantelis⁴, Mieke L van Driel ⁵

¹General Practice and Rural Medicine, James Cook University, Mackay, Australia. ²Anton Breinl Research Centre for Health Systems Strengthening, Townsville, Australia.³School of Medicine and Dentistry, James Cook University, Mackay, Australia. ⁴Centre for Health Informatics, Institute of Population Health, The University of Manchester, Manchester, UK.⁵Discipline of General Practice, School of Medicine, The University of Queensland, Brisbane, Australia

Contact: Clare F Heal, General Practice and Rural Medicine, James Cook University, Mackay Base Hospital, Bridge Road, Mackay, Queensland, 4740, Australia. 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。.

Editorial group: Cochrane Wounds Group.

Publication status and date: New, published in Issue 11, 2016.

Citation: Heal CF, Banks JL, Lepper PD, Kontopantelis E, van Driel ML. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention. Cochrane Database of Systematic Reviews 2016, Issue 11. Art. No.: CD011426. DOI: 10.1002/14651858.CD011426.pub2.

０.０１％次氯酸在白内障超声乳化术前应用的安全性和有效性

王雨蒙，陆秋辰，赵颖奕，史灿灿，李明新，王贺

ADJUNCTIVE DEBRIDEMENT WITH HYPOCHLOROUS ACID LEADS TO A HEALING TRAJECTORY OF COMPLEX WOUNDS IN CHILDREN

Ferne T. Elsass, MSN, RN, CPN, CWON; Clinical Practice and Education Specialist of Wound and Ostomy, Children’s Hospital of The King’s Daughters, Norfolk, VA 23507

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次氯酸消毒剂在骨科术后切口愈合中的应用：一项实效性随机对照试验 2026-09-05 00:00

张燕１，朱迪１，孙磊１，王任贤２

（１．徐州仁慈医院感染管理科，江苏徐州２４１００４；２．台湾防疫学会，台湾台中４０４４７）

［摘要］目的探讨次氯酸应用于外科术后切口愈合及减少术后切口感染的临床效果。方法纳入某三级甲等医院足踝外科住院患者，按手术时序进行分组：第一阶段（２０２４年１０月１６日—１２月１６日）为对照组，采用４５００～５５００ｍｇ／Ｌ碘伏消毒术后切口；第二阶段（２０２４年１２月１７日—２０２５年２月１７日）为试验组，采用（１１０±１６．５）ｍｇ／Ｌ次氯酸消毒术后切口。术后第１、３、５、７、１０、１４天进行切口消毒、指标评价并记录。主要结局指标为手术部位感染，次要指标包括术后４８ｈ红肿、过敏及疼痛程度评分。结果对照组感染发病率为０．９６％，术后４８ｈ红肿发生率为１６．９９％，疼痛评分（１．４１±０．４９）分；试验组未发生感染，术后４８ｈ红肿发生率为９．５８％，疼痛评分为（１．３６±０．４８）分。两组感染发病率及疼痛评分差异均无统计学意义（均犘＞０．０５），红肿发生率差异具有统计学意义（犘＝０．００６）。按切口类型进行分层分析显示，开放性外伤亚组中，对照组感染发病率为３．１９％，红肿发生率为２９．７９％，疼痛评分为（１．６２±０．４９）分；试验组术后４８ｈ红肿发生率为８．１４％，疼痛评分为（１．４１±０．４９）分，两组感染发病率差异无统计学意义（犘＞０．０５），红肿发生率（犘＜０．００１）及疼痛程度评分（犘＝０．００５）差异均有统计学意义。闭合性外伤亚组中，各结局指标组间比较差异均无统计学意义（均犘＞０．０５）。结论次氯酸溶液在闭合性外伤术后切口应用的效果与碘伏相当；在开放性外伤术后应用中，其控制术后红肿发生及疼痛的效果优于碘伏。

［关键词］次氯酸；碘伏；骨科；切口愈合；实效性随机对照试验

［中图分类号］Ｒ１８１．３＋２Ｒ１８７＋．１
Comparison of the preventive effects of slightly acidic HOCl mouthwash and CHX mouthwash for oral diseases. 2026-09-04 00:00

Yu-Rin Kim¹, Seoul-Hee Nam^2*

¹Department of Dental Hygiene, Silla University, Busan, Republic of Korea

²Department of Dental Hygiene, College of Health Science, Kangwon National University, Samcheok-si, Republic of Korea

Abstract

The purpose of this study was to compare the preventive effects of the slightly acidic hypochlorous acid (HOCl) mouthwash and chlorhexidine (CHX) mouthwash as a chemical plaque control agent for oral diseases. This study was conducted for 15 patients who had no systemic disease among the patients who visited M Dental Clinic in Busan, South Korea, excluding the patients with incomplete data. The patients were divided into three groups: five patients in the 0.005% CHX (Bukwang Pharm Co., Ltd.) gargling group, five in the slightly acidic HOCl gargling group, and five in the saline gargling group. The patients were instructed to gargle with 15 ml of each mouthwash for 1 minute, and to then spit saliva for 1 min to remove the remaining gargling solution. Then the halitosis, O’Leary index, dental caries activity, bacterial species, and motility were measured. As a result, these decreased in the CHX gargling group compared to the saline gargling group, but the difference was not statistically significant (P>0.005), while there were significant decreases in the HOCl gargling group. The O’Leary index, Snyder test, bacterial motility, and Filamentous more distinctly and effectively decreased in the HOCl gargling group than in the CHX gargling group, showing statistically significant differences (p<0.05). Based on this study, CHX, which is currently widely used in dentistry, can be said to be inconvenient to use due to its strong fragrance and taste, and there have been many reports on the side effects on the oral cavity of its long-term use. Therefore, if HOCl, which is harmless to the human body and has an extensive sterilizing power, is used instead of CHX, safe and effective oral care will be achieved.

Keywords: Dental caries, Periodontal disease, Slightly acidic hypochlorous acid (HOCl), Chlorhexidine (CHX),Bacteria.
Does chlorhexidine and povidone-iodine preoperative antisepsis reduce surgical site infection in cranial neurosurgery? 2026-09-03 00:00

BM Davies, HC Patel

Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, UK

ABSTRACT

INTRODUCTION Surgical site infection (SSI) is a significant cause of postoperative morbidity and mortality. Effective preoperative antisepsis is a recognised prophylactic, with commonly used agents including chlorhexidine (CHG) and povidone-iodine (PVI). However, there is emerging evidence to suggest an additional benefit when they are used in combination. METHODS We analysed data from our prospective SSI database on patients undergoing clean cranial neurosurgery between October 2011 and April 2014. We compared the case-mix adjusted odds of developing a SSI in patients undergoing skin preparation with CGH or PVI alone or in combination.

RESULTS SSIs were detected in 2.6% of 1146 cases. Antisepsis with PVI alone was performed in 654 (57%) procedures, while 276 (24%) had CHG alone and 216 (19%) CHG and PVI together. SSIs were associated with longer operating time (p<0.001) and

younger age (p=0.03). Surgery type (p<0.001) and length of operation (p<0.001) were significantly different between antisepsis groups. In a binary logistic regression model, CHG and PVI was associated with a significant reduction in the likelihood of developing an SSI (adjusted odds ratio [AOR] 0.12, 95% confidence interval [CI] 0.02–0.63) than either agent alone. There was no difference in SSI rates between CHG and PVI alone (AOR 0.60, 95% CI 0.24–1.5).

CONCLUSIONS Combination skin preparation with CHG and PVI significantly reduced SSI rates compared to CHG or PVI alone. A prospective, randomized study validating these findings is now warranted.

KEYWORDS

Antisepsis – Chlorhexidine – Neurosurgery – Povidone-iodine – Surgical wound infection

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Skin preparation for preventing infection following caesarean section

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention

０.０１％次氯酸在白内障超声乳化术前应用的安全性和有效性

ADJUNCTIVE DEBRIDEMENT WITH HYPOCHLOROUS ACID LEADS TO A HEALING TRAJECTORY OF COMPLEX WOUNDS IN CHILDREN

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

Skin preparation for preventing infection following caesarean section

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention

０.０１％次氯酸在白内障超声乳化术前应用的安全性和有 效性

ADJUNCTIVE DEBRIDEMENT WITH HYPOCHLOROUS ACID LEADS TO A HEALING TRAJECTORY OF COMPLEX WOUNDS IN CHILDREN

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学术会议

伤口世界提示

０.０１％次氯酸在白内障超声乳化术前应用的安全性和有效性