文献精选

男性雄激素性秃发中西医诊疗专家共识

国家皮肤和性传播疾病专业质控中心毛发专家委员会,国家中西医结合医学中心毛发专病医联体,中国整形美容协会中医美容分会,中华中医药学会皮肤科分会毛发学组,北京中西医结合学会皮肤性病专业委员会毛发学组

National Professional Quality Control Center for Skin and Sexually Transmitted Diseases, Hair Expert Comittee; National Center of Integrated Traditional Chinese and Westerm Medicine Hair Diseases Medical Treatment Combination; Chinese Plastic and Aesthetic Association of Traditional Chinese Medicine Cosmetology Branch; Working Group for Hair Diseases, China Association of Chinese Medicine, Dermatology Branch; Working Group for Hair Diseases, Beijing Association of the Integrating of Traditional and Western Medicine Dematological and Venereal Diseases Professional Committee

[摘要]雄激素性秃发(AGA)是临床最常见的脱发性疾病,男性AGA发病率更高,严重影响患者的身心健康和生活质量。目前认为该病与遗传易感性和脱发部位毛囊细胞对雄激素的高反应性密切相关。诊断主要依据病史、脱发模式和皮肤镜检查。中医药治疗是我国AGA防治的优势和特色,为了推广男性AGA的规范化中西医诊治理念,提高我国在该领域的诊治水平,特组织编写了该专家共识。

[关键词]雄激素性秃发,男性; 中西医;诊疗;专家共识
[中图分类号] R758.71
[文献标识码] A
[文章编号] 1000- 4963(2024 )05- -0305-07
doi: 10.16761/j.cnki.1000- 4963.2024.05.014

2023中国临床实践指南:雄激素性脱发诊断与治疗

中华医学会整形外科学分会中国雄激素性脱发诊断与治疗指南制订工作组整形美容 .
专业国家级医疗质量控制中心中国整形美容协会毛发医学分会中国女医师协会.
整形美容专业委员会
通信作者:张菊芳,西湖大学医学院附属杭州市第一人民医院医疗美容科,杭州310006, Email: zhjuf@ vip. sina. com;

吴文育,复旦大学附属华山医院皮肤科,上海200040, Email: wuwenyu@ huashan. org. cn;

牛冬,浙江农林大学动物科技学院、动物医学院,杭州311300, Email: dniu@ zafu. edu.cn;

龙笑,中国医学科学院北京协和医学院北京协和医院整形外科,北京100032, Email: pumclongxiao@ 126. com.

[摘要] 雄激素性脱发发病率逐年增高并呈现低龄化的趋势,困扰着众多患者。对于雄激素性脱发的治疗,近年来出现了很多新方式和思路，因此雄激素性脱发的治疗策略需要随之更新;另外,随着近年来毛发行业的发展,大量的从业者涌人雄激素性脱发诊治的相关岗位,因此需要经过证实的指南来进行指引。指南制订工作组遴选了有关临床问题，经过证据检索、专家论证,形成了相关推荐意见,以期能够进一步规范雄激素性脱发的治疗决策。

[关键词] 脱发;雄激素性脱发; 整形外科;指南
基金项目:杭州市医学重点学科( 002020004);上海市级医院皮肤科临床能力促进与提升专科联盟(SHDC22022302);上海市重中之重研究中心建设项目(2023702018);上海毛发医学工程技术研究中心(19D22250500);浙江省自然科学基金重点项目(LZ22C010003);北京协和医院中央高水平医院临床科研专项( 2022-PUMCH-B-042)

DOI: 10. 3760/ema. j. en1 14453-20231029-00156

Chinese guideline for the diagnosis and treatment of androgenetic alopecia ( 2023)

The Working Group of Chinese Guideline for the Diagnosis and Treatment of Androgenetic Alopeeia, Chinese Medical Association of Plastic Surgery; National Medical Quality Control Center for Plastic Surgery; Society of Hair Medicine, Chinese Association of Plastics and Aesthetics; Plastic & Aesthetic Surgery Comitee, China Medical Women 's Association

Corresponding author: Zhang Jufang， Department of Medical Cosmetology， Hangzhou First People' s Hospital, Westlake University, Hangzhou 310006， China, Email: zhjuf@ rip. sina. com; Wu Wenyu,
Department of Dermatology, Huashan Hospital, F'udan University, Shanghai 200040， China， Email: wuwenyu@ huashan. org. cn; Niu Dong, Animal Science College and Animal Medicine College , Zhejiang
A&F University , Hangzhou 311300，China, Email: dniu@ zafu. edu. cn; Long Xiao, Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100032, China ，Email: pumclongxiao@ 126. com

[ Summary] The incidence rate of androgenetice alopecia is increasing year by year and presents a trend of younger age, which puzzles many patients. In recent years, there have been many new treatment
methods and ideas for androgenetic alopecia, so the treatment strategies for androgenetic alopecia need to be : updated accordingly. In addition, with the development of the hair industry in recent years, a large number of practitioners have flocked to positions related to the diagnosis and treatment of androgenetie alopecia, so proven guidelines are needed for guidance. The guide writing team selected relevant clinical issues, gave recommendations based on a thorough literature review of the latest reports and expert' s evaluation, in the hope of providing a treatment algorithm for androgenetic alopecia.

[Key words] Alopecia; Androgenetic alopecia; Plastie surgery; Guideline

Fund program: Hangzhou Key Discipline of Medieine ( 0020200044 ) ; Shanghai M unicipal Hospital Dermatology Clinical Ability Promotion and Enhancement Specialist Alliance .
( SHDC22022302) ; Shanghai Most Important Research Center Construction Project ( 2023Z702018) ; Shanghai Hair Medical Engineering Technology Research Center ( 19DZ2250500); Zhejiang Province
Natural Science Foundation Key Project ( LZ22C010003 ); National High Level Hospital Clinical Research Funding ( 2022-PUMCH-B-042)

Disclosure of Conflicts of Interest: The authors have no financial interest to declare in relation to the content of this article.

DOI: 10. 3760/ ema. j. en1 14453-2023 1029-00156

中国敏感性皮肤诊治专家共识

何黎1 ，郑捷2 ，马慧群3 ，郝飞4 ，刘玮5 ，王刚6 ，李利7 ，高兴华8 ，项蕾红9 ，吴艳1 0 ，谢红付11 ，袁超12 ，林彤13 ，赖维14 ，刘盛秀1 5 ，张丽8 ，李吉1 1 ，严淑贤9 ，崔勇16 ，李虹17 ，陈抗18 ，周展超19 ，钟莉20 ，梁虹2 1 ，骆丹2 2 ，卢凤艳23 ，熊霞24 ，庞勤2 5 ，王玮蓁26 ，王秀丽12 ，朱丽萍1

［中图分类号］Ｒ 593． 1

［文献标识码］ A

［文章编号］ 1001 － 7089( 2017) 01 － 0001 － 04

［DOI］ 10. 13735 /j. cjdv. 1001-7089. 201611168

［基金项目］云南省“高原皮肤病防治转化医学协同创新中心”( 601160707) ; 教育部 2013 年度“创新团队发展计划”( ＲIT13067) 资助项目

［作者单位］ 1．昆明医科大学第一附属医院，云南昆明 650032;

2．上海交通大学附属瑞金医院，上海 200240;

3．西安交通大学第二附属医院，陕西西安710000;

4．第三军医大学第一附属医院( 西南医院) ，重庆400038;

5．北京空军总医院，北京100142;

6．第四军医大学西京医院，陕西西安710000;

7．四川大学华西医院，四川成都610041;

8．中国医科大学附属第一医院，辽宁沈阳110001;

9．复旦大学附属华山医院，上海200040;

10．北京大学第一医院，北京 100034;

11．中南大学湘雅医院，湖南长沙 410008;

12．上海市皮肤病医院，上海 200443;

13．中国医学科学院皮肤病医院，江苏南京210042;

14．中山大学附属第三医院，广东广州 510630;

15．安徽医科大学附属医院，安徽合肥 230032;

16．中日友好医院，北京 100029;

17．昆明薇诺娜皮肤医疗美容有限公司，云南昆明 650031;

18．海南省皮肤病医院，海南海口 570000;

19．南京展超丽格医疗美容诊所，江苏南京 210000;

20．重庆大学附属医院，重庆 400038;

21．武汉大学人民医院，湖北武汉 430060;

22．南京医科大学第一附属医院，江苏南京 210029;

23．曲靖市第一人民医院，云南曲靖 655000;

24．西南医科大学附属中医医院，重庆 400038;

25．天津市中医药研究院附属医院( 长征医院) ，天津 300120;

26．武汉市第一医院，湖北武汉 430070

［学术秘书］朱丽萍，E-mail: 13529062890@ 103． com

A New Ten-item Questionnaire For Assessing Sensitive Skin: The Sensitive Scale-10

Laurent Misery 1,2 , Catherine Jean-Decoster3 , Sophie Mery 3 , Victor Georgescu 3 and Vincent Sibaud 3 1 Laboratory of Neurosciences of Brest, University of Western Brittany, 2 Department of Dermatology, University Hospital of Brest, Brest, and 3 Dermatological Laboratories Avène, Lavaur, France

Sensitive skin is common but until now there has been no scale for measuring its severity. The Sensitive Scale is a new scale with a 14-item and a 10-item version that was tested in 11 countries in different languages on 2,966 participants. The aim of this study was to validate the pertinence of using the Sensitive Scale to measure the severity of sensitive skin. The internal consistency was high. Correlations with the dry skin type, higher age, female gender, fair phototypes and Dermatology Life Quality Index were found. Using the 10-item version appeared to be preferable because it was quicker and easier to complete, with the same internal consistency and the 4 items that were excluded were very rarely observed in patients. The mean initial scores were around 44/140 and 37/100. The use of a cream for sensitive skin showed the pertinence of the scale before and after treatment. Key words: sensitive skin; DLQI; scale; severity; questionnaire.

Accepted Apr 2, 2014; Epub ahead of print Apr 7, 2014

Acta Derm Venereol 2014; 94: 635–639.

Prof Laurent Misery, Department of Dermatology, University Hospital of Brest, 2 avenue Foch, FR-29200 Brest, France. E-mail: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

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K2 Content

GLP1R Gene Expression and Kidney Disease Progression 2024-11-04 00:00

Jefferson L. Triozzi, MD, MSCI; Zhihong Yu, MS, PhD; Ayush Giri, MS, PhD; Hua-Chang Chen, PhD; Otis D. Wilson, BBA; Brian Ferolito, MS; T. Alp Ikizler, MD; Elvis A. Akwo, MD, MS; Cassianne Robinson-Cohen, PhD; John Michael Gaziano, MD, MPH; Kelly Cho, PhD, MPH; Lawrence S. Phillips, MD; Ran Tao, PhD; Alexandre C. Pereira, MD, PhD; Adriana M. Hung, MD, MPH; for the VA Million Veteran Program

Key Points

Question Are glucagon-like peptide 1 receptor agonists (GLP-1RAs) associated with kidney disease progression?

Findings In this genetic association study of 353 153 adults, higher genetic GLP1R gene expression as a proxy for GLP-1RAs was associated with a small reduction in the risk of kidney disease progression, even after adjusting for obesity and diabetes.

Meaning These findings support a nephroprotective role of GLP-1RAs.

Abstract

IMPORTANCE Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have nephroprotective properties beyond those related to weight loss and glycemic control.

OBJECTIVE To investigate the association of genetically proxied GLP-1RAs with kidney disease

DESIGN, SETTING, AND PARTICIPANTS This genetic association study assembled a national retrospective cohort of veterans aged 18 years or older from the US Department of Veterans Affairs Million Veteran Program between January 10, 2011, and December 31, 2021. Data were analyzed from November 2023 to February 2024.

EXPOSURES Genetic risk score for systemic GLP1R gene expression that was calculated for each study participant based on genetic variants associated with GLP1R mRNA levels across all tissue samples within the Genotype-Tissue Expression project.

MAIN OUTCOMES AND MEASURES The primary composite outcome was incident end-stage kidney disease or a 40% decline in estimated glomerular filtration rate. Cox proportional hazards regression survival analysis assessed the association between genetically proxied GLP-1RAs and kidney disease progression.

RESULTS Among 353 153 individuals (92.5% men), median age was 66 years (IQR, 58.0-72.0 years) and median follow-up was 5.1 years (IQR, 3.1-7.2 years). Overall, 25.7% had diabetes, and 45.0% had obesity. A total of 4.6% experienced kidney disease progression. Overall, higher genetic GLP1R gene expression was associated with a lower risk of kidney disease progression in the unadjusted model (hazard ratio [HR], 0.96; 95% CI, 0.92-0.99; P = .02) and in the fully adjusted model accounting for baseline patient characteristics, body mass index, and the presence or absence of diabetes (HR, 0.96; 95% CI, 0.92-1.00; P = .04). The results were similar in sensitivity analyses stratified by diabetes or obesity status.

CONCLUSIONS AND RELEVANCE In this genetic association study, higher GLP1R gene expression was associated with a small reduction in risk of kidney disease progression. These findings support pleiotropic nephroprotective mechanisms of GLP-1RAs independent of their effects on body weight and glycemic control.
Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations 2024-10-31 00:00

Daniela Milosheska . Robert Roskar

Received: August 17, 2022 / Accepted: September 6, 2022 / Published online: October 11, 2022

©The Author(s) 2022

ABSTRACT

Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are one of the most popular ingredients used in antiaging treatments. Among the representatives of retinoids, tretinoin is considered the most effective agent with proven antiaging effects on the skin and can be found in formulations approved as medicines for topical treatment of acne, facial wrinkles, and hyperpigmentation. Other retinoids present in topical medicines are used for various indications, but only tazarotene is also approved as adjunctive agent for treatment of facial fine wrinkling and pigmentation. The most commonly used retinoids such as retinol, retinaldehyde, and retinyl palmitate are contained in cosmeceuticals regulated as cosmetics. Since clinical efficacy studies are not required for marketing cosmetic formulations, there are concerns about the efficacy of these retinoids.

From a formulation perspective, retinoids pose a challenge to researchers as a result of their proven instability, low penetration, and potential for skin irritation. Therefore, novel delivery systems based on nanotechnology are being developed to overcome the limitations of conventional formulations and improve user compliance. In this review, the clinical evidence for retinoids in conventional and nanoformulations for topical antiaging treatments was evaluated. In addition, an overview of the comparison clinical trials between tretinoin and other retinoids is presented. In general, there is a lack of evidence from properly designed clinical trials to support the claimed efficacy of the most commonly used retinoids as antiaging agents in cosmeceuticals. Of the other retinoids contained in medicines, tazarotene and adapalene have clinically evaluated antiaging effects compared to tretinoin and may be considered as potential alternatives for antiaging treatments. The promising potential of retinoid nanoformulations requires a more comprehensive evaluation with additional studies to support the preliminary findings.

Keywords: Antiaging; Clinical evidence; Cosmeceuticals; Nanoformulations; Retinoids; Retinol; Tretinoin

Key Summary Points

Tretinoin is the retinoid present in medicines for topical application with the strongest clinical evidence of antiaging Tazarotene and adapalene may be considered as tretinoin alternatives for antiaging treatments.

Clinical evidence is lacking for retinoids contained in cosmeceuticals for topical antiaging treatments.

Novel formulations based on nanotechnology are being developed to overcome the major drawbacks of retinoid Further evaluation with in vivo testing and clinical trials are needed to support the preclinical results for the developed nanoformulations containing retinoids.

D. Milosheska INSLAB, Maribor, Slovenia

R. Roskar (&)

University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, 1000 Ljubljana, Slovenia

e-mail: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations 2024-10-30 00:00

Gérald J. Prud’homme1,2 *, Mervé Kurt 2 and Qinghua Wang3,4

1 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada,

2 Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Unity Health Toronto, Toronto, ON, Canada,

3 Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China,

4 Shanghai Yinuo Pharmaceutical Co., Ltd., Shanghai, China

Edited by:

Cátia F. Lourenço, University of Coimbra, Portugal

Reviewed by:

Mujib Ullah, Stanford University, United States Taylor Landry, East Carolina University, United States

*Correspondence:

Gérald J. Prud’homme 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Specialty section:

This article was submitted to Molecular Mechanisms of Aging, a section of the journal Frontiers in Aging

Received: 28 April 2022

Accepted: 06 June 2022

Published: 12 July 2022

Citation:

Prud’homme GJ, Kurt M and Wang Q (2022) Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations. Front. Aging 3:931331.

doi: 10.3389/fragi.2022.931331

The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened lifespan, stunted growth, renal disease, hyperphosphatemia, hypercalcemia, vascular calcification, cardiac hypertrophy, hypertension, pulmonary disease, cognitive impairment, multi-organ atrophy and fibrosis. Overexpression of Klotho has opposite effects, extending lifespan. In humans, Klotho levels decline with age, chronic kidney disease, diabetes, Alzheimer’s disease and other conditions. Low Klotho levels correlate with an increase in the death rate from all causes. Klotho acts either as an obligate coreceptor for fibroblast growth factor 23 (FGF23), or as a soluble pleiotropic endocrine hormone (s-Klotho). It is mainly produced in the kidneys, but also in the brain, pancreas and other tissues. On renal tubular-cell membranes, it associates with FGF receptors to bind FGF23. Produced in bones, FGF23 regulates renal excretion of phosphate (phosphaturic effect) and vitamin D metabolism. Lack of Klotho or FGF23 results in hyperphosphatemia and hypervitaminosis D. With age, human renal function often deteriorates, lowering Klotho levels. This appears to promote age-related pathology. Remarkably, Klotho inhibits four pathways that have been linked to aging in various ways: Transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), Wnt and NF-κB. These can induce cellular senescence, apoptosis, inflammation, immune dysfunction, fibrosis and neoplasia. Furthermore, Klotho increases cell-protective antioxidant enzymes through Nrf2 and FoxO. In accord, preclinical Klotho therapy ameliorated renal, cardiovascular, diabetes-related and neurodegenerative diseases, as well as cancer. s-Klotho protein injection was effective, but requires further investigation. Several drugs enhance circulating Klotho levels, and some cross the blood-brain barrier to potentially act in the brain. In clinical trials, increased Klotho was noted with renin-angiotensin system inhibitors (losartan, valsartan), a statin (fluvastatin), mTOR inhibitors (rapamycin, everolimus), vitamin D and pentoxifylline. In preclinical work, antidiabetic drugs (metformin, GLP-1-based, GABA, PPAR-γ agonists) also enhanced Klotho. Several traditional medicines and/or nutraceuticals increased Klotho in rodents, including astaxanthin, curcumin, ginseng, ligustilide and resveratrol. Notably, exercise and sport activity increased Klotho. This review addresses molecular, physiological and therapeutic aspects of Klotho.

Keywords: aging, FGF23, hyperphosphatemia, klotho, IGF-1, NF-KappaB, TGF-beta, Wnt

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

男性雄激素性秃发中西医诊疗专家共识

2023中国临床实践指南:雄激素性脱发诊断与治疗

中国敏感性皮肤诊治专家共识

A New Ten-item Questionnaire For Assessing Sensitive Skin: The Sensitive Scale-10

学术会议

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Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

男性雄激素性秃发中西医诊疗专家共识

2023中国临床实践指南:雄激素性脱发诊断与治疗

中国敏感性皮肤诊治专家共识

A New Ten-item Questionnaire For Assessing Sensitive Skin: The Sensitive Scale-10

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学术会议

伤口世界提示