Bronte Jeffrey1,2*, Logan Gardner6,7, Michelle Le1 , Julie Frost1 and Ming Wei Lin1,3,4,5
*Correspondence: Bronte Jeffrey 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
1 Department of Clinical Immunology, Westmead Hospital, Sydney, Australia
2 St Vincent’s Clinical School, University of New South Wales, Sydney, Australia
3 Faculty of Medicine and Health, University of Sydney, Sydney, Australia
4 Department of Immunopathology, Westmead Hospital, Sydney, Australia
5 Centre for Immunology and Allergy Research, Westmead Institute of Medical Research, Sydney, Australia
6 Allergy, Asthma and Clinical Immunology, The Alfred Hospital, Melbourne, Australia
7 School of Public Health & Preventive Medicine, Monash University, Melbourne, Australia
© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
İbrahim Halil Aydoğdu | Esen Özkaya Department of Dermatology and Venereology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Correspondence: İbrahim Halil Aydoğdu (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)
Received: 26 April 2025 | Revised: 14 June 2025 | Accepted: 30 June 2025
Funding: The authors received no specific funding for this work.
Keywords: allergic contact dermatitis | carbamate | epidemiology | glove | mercapto | nonoccupational | occupational | patch test | rubber additives | thiuram
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2025 The Author(s). Contact Dermatitis published by John Wiley & Sons Ltd.
ABSTRACT
Background: Rubber additives are common causes of allergic contact dermatitis (ACD) worldwide, yet data from Turkey remain
Objectives: To evaluate the prevalence of rubber additive sensitisation and its clinical/occupational relevance in a tertiary re ferral centre.
Methods: A retrospective study on 2687 consecutively patch-tested patients with rubber additives at our allergy unit between 1996 and 2023.
Results: Rubber sensitisation was found in 10.6%, with a slight increase after 2010. Male predominance was noted (female: male=1:2.3). Thiurams and carbamates were the most frequent sensitizers. ACD was diagnosed in 7.9%, primarily caused by gloves (85.5%). Hands were most commonly affected (94.4%). Logistic regression analysis showed that thiuram and carba mate sensitisation was significantly associated with hand eczema, while benzothiazole derivatives were linked to foot eczema. Airborne ACD occurred in 4.2%, mainly in healthcare workers. Hand eczema with and without wrist extension was observed with similar frequency. Occupational ACD accounted for 79.3% of cases, especially among construction (56.8%) and healthcare workers (14.8%), with a relative increase in the latter group after 2015.
Conclusions: The high prevalence of sensitisation from rubber gloves is concerning. Legal measures are urgently needed, includ ing safer additives and clearer glove labelling. Patch testing remains essential, even without the classic glove-pattern distribution.
Authors
Li Wei
Yuting Bao
Maria Hendrika van Zuilen
Preetha Kamath
Joy E. Schank
Catherine R. Ratliff
David Strider
Matthew Regulski
Barbara C. Zeiger
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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