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Mandy Li Ling Tan, Jiah Shin Chin, Leigh Madden & David L. Becker
To cite this article: Mandy Li Ling Tan, Jiah Shin Chin, Leigh Madden & David L. Becker (2022): Challenges faced in developing an ideal chronic wound model, Expert Opinion on Drug Discovery,
DOI: 10.1080/17460441.2023.2158809
To link to this article: https://doi.org/10.1080/17460441.2023.2158809
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Published online: 26 Dec 2022.
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Mandy Li Ling Tana,b# , Jiah Shin Chinb# , Leigh Maddenb and David L. Beckerb,c,d a Nanyang Institute of Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, 639798, Singapore; b Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore; c Skin Research Institute Singapore, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; d National Skin Centre, Mandalay Road, Singapore
ABSTRACT
Introduction: Chronic wounds are a major drain on healthcare resources and can lead to substantial reductions in quality of life for those affected. Moreover, they often precede serious events such as limb amputations and premature death. In the long run, this burden is likely to escalate with an ageing population and lifestyle diseases such as obesity. Thus far, the identification of beneficial therapeutics against chronic wounds have been hindered by the lack of an ideal chronic wound animal model. Although animal models of delayed healing have been developed, none of these models fully recapitulate the complexity of the human chronic wound condition. Furthermore, most animals do not develop chronic wounds. Only the thoroughbred racehorse develops chronic ulcers.
Areas covered: In this review, the different characteristics of chronic wounds that highlight its complexity are described. In addition, currently available models reflecting different aspects of chronic wound pathology and their relevance to human chronic wounds are discussed. This article concludes by listing relevant features representative of an ideal chronic wound model. Additionally, alternative approaches for the development of chronic wound models are discussed.
Expert opinion: Delayed models of healing, including the streptozotocin diabetic model, skin flap model and magnet-induced IR models have emerged. While these models have been widely adopted for preclinical therapeutic testing, their relevance towards human chronic wounds remains debatable. In particular, current delayed healing models often fail to fully incorporate the key characteristics of chronic ulcers. Ultimately, more representative models are required to expedite the advancement of novel therapeutics to the clinic.
ARTICLE HISTORY
Received 5 October 2021 Accepted 12 December 2022
KEYWORDS
Animal models; biofilm infection; chronic wounds; delayed healing models; delayed wound closure; excessive extracellular matrix degradation; hyper thickened epidermis; increased senescent cells population; persistent inflammation
艾则孜●吾买尔，姜爱新，曹淑娟
(喀什地区第一人民医院眼科中心，新疆喀什844000)
[摘要] 目的:通过随机对照试验，观察氦氖激光在喀什地区弱视儿童中的治疗效果。方法:选取2016年2月至2018年11月期间就诊喀什地区第一人民医院符合纳排标准的弱视儿童，按随机数字表法，分为试验组(氦氖激光+弱视常规治疗组)与对照组(弱视常规治疗组)，比较两组的弱视治疗效果。
结果:本试验成功纳入弱视儿童111例(177眼),其中试验组61例(97眼)，对照组S0例(80眼)。与对照组相比，汉族试验组弱视儿童效果明显(P=0.023)，维吾尔族试验组弱视儿童未见明显疗效(P=0.481);试验组与对照组在喀什地区不同年龄、不同弱视程度、不同弱视类型及不同弱视眼数儿童中未见明显差异(P>0.05)。结论:氦氖激光治疗喀什地区弱视儿童作用有限，为避免过度医疗，不建议在南疆地区开展。
[关键词] 氦氖激光;弱视;随机对照研究
Efficacy of helium-neon laser in amblyopia of Kashgar children: A randomized controlled trial
AizeziWUMAIER, JIANG Aixin, CAO Shujuan
(Ophthalmological Center, First People's Hospital in Kashgar, Kashgar Xinjiang 844000, China)
Abstract Objective: To observe the therapeutic effect of helium-neon laser in amblyopia children in Kashgar by a randomized controlled trial. Methods: Amblyopia children who met eligibility criteria during February 2016 to November 2018 were selected and divided into two groups according to random number table: test group (helium neon laser + conventional treatment for amblyopia) and control group (conventional treatment for amblyopia). The effects of amblyopia treatment were compared between two groups. Results: One hundred and eleven amblyopic children (177 eyes), including 61 children (97 eyes) of the test group and 50 children (80 eyes) of the control group were included in this study. The efect of helium-neon laser was significant in Han children (P=0.023), but not in Uygur children (P=0.481) in the test group compared with the control group.
Condusion: Helium-neon laser has limited effect in treating children with amblyopia in K ashgar region. To avoid over-treatment, it is not recommended to perform it in southern Xinjiang.
Keywords：helium neon laser; amblyopia; randomized controlled trial
陈敏，高春雪
(吉林国健美容医院，吉林长春，130013)
[摘要]目的探讨激光美容技术治疗色素性疾病色素痣的临床效果，为临床使用提供参考依据。方法选取我院2016年16月~ 2018年16月所收治色素痣色素性疾病患者78例，随机分为研究组和对照组。对照组39例，予以微创切除术;研究组39例，予以激光美容针。比较两组临床表现、疗效、不良反应差异。结果研究组患者中， 创面愈合时间为(8.19士 1.76)d、创面疼痛评分为(2.21+1.07) 分，均显著低于对照组，t分别为8.253、 4.761， 差异具有统计学意义(P< 0.05) 。研究组总有效率为97.44%，明显高于对照组的79 . 49%，(P< 0.05)。研究组患者中，色素沉着12例、红斑1例，不良反应发生率为33.35%，明显低于对照组的69.23%, X2为8.672，差异具有统计学意义(P< 0.05)。结论激激光 美容技术可明显提升色素痣临床疗效，缩短治疗周期，减轻患者痛苦，且不良反应更少，安全性高，更有利于改善患者外貌美观度， 值得临床推广应用。
[关键词]激光美容; 色素痣;不良反应 DOI; 10. 19593/j. issn. 2095-0721. 2019. 01. 016
Clinical effect analysis of carbon dioxide lattice laser cosmetic technique in the treatment of pigmented nevus CHEN Min, GAO Chun-xue (Jilin National Health and Beauty Hospital, Jilin Province, 130013,China)
[ABSTRACT] Objective To investigate the clinical effect of laser cosmetology in the treatment of pigmented nevus of pigmentary diseases, and to provide reference for clinical use. Methods 78 patients with pigmented nevus treated in our hospital from June 2016 to June 2018 were randomly divided into study group and control group. 39 cases in the control group were treated with minimally invasive resection and 39 cases in the study group were treated with laser cosmetic needle. The differences of clinical manifestations,curative effects and adverse reactions between the two groups were compared. Results In the study group, the wound healing time was (8.19+1.76) D and the wound pain score was (2.21+1 .07), which were significantly lower than those in the control group, t was 8.253 and 4.761, respectively, with statistical significance (P <0.05);The total effective rate was 97.44% in the study group, which was signifcantly higher than 79.49% in the control group (P <0.05); There were 12 cases of pigmentation and 1 case of erythema in the study group. The incidence of adverse reactions was 33.33%, which was significantly lower than 69.23% and 8.672 in the control group (P <0.05);. Conclusion Laser Laser Beauty Technology can significantly improve the clinical eficacy of pigmented nevus, shorten the treatment cycle, aleviate the pain of patients, and less adverse reactions, high safety, more conducive to improving the appearance and beauty of patients, worthy of clinical application.
[KEY WORDS] laser cosmetology; pigmented nevus; adverse reactions
赵宏锟,邹悦,李云琴
引用:赵宏锟,邹悦,李云琴.阈下微脉冲激光在眼科疾病治疗中的应用.国际眼科杂志2020;20(1) :92-95
基金项目:云南省科技厅-昆明医科大学应用基础研究联合专项
资金项目[ No.2017FE467(- 146), 2018FE001(-077)];白求恩●朗沐中青年眼科科研基金( No. BJ-LM2018009J)
作者单位:(650021)中国云南省昆明市,云南省第二人民医院
昆明医科大学第四附属医院云南省眼科医院
作者简介:赵宏锟,硕士研究生,住院医师,研究方向:眼底病。
通讯作者:李云琴,博士,副主任医师，研究方向:眼底病.
liyunqin2004@ 126.com
收稿日期: 2019-06-21
修回日期: 2019-11-21
摘要
阈下微脉冲激光( SML)是-种短促重复的脉冲激光,与传统激光相比,SML不会破坏视网膜色素上皮(RPE)细胞，也不会留下激光斑,是一-种相对安全的治疗手段。SML可能的作用机制是通过重复的阈值下能量激活RPE细胞,促使热休克蛋白表达增加,从而启动RPE细胞的调节修复功能。目前SML的适应证主要有中心性浆液性脉络膜视网膜病变、糖尿病性黄斑水肿、视网膜静脉阻塞继发黄斑水肿、重度非增殖期糖尿病视网膜病变和增殖期糖尿病视网膜病变。本文旨在综述SML的作用机制及其在各适应证中的应用,以期为SML的临床应用提供参考。
关键词:阈下微脉冲激光;应用;机制;中心性浆液性脉络膜视网膜病变;糖尿病性黄斑水肿;糖尿病视网膜病变;视网膜静脉阻塞
DOI: 10.3980/j. issn.1672- 5123.2020.1.21
Process in application of subthreshold micropulse laser
Hong- -Kun Zhao, Yue Zou, Yun- Qin Li .
Foundation items: Yunnan Science and Technology Department -Kunming Medical University Joint Fund for Applied Basic Research [ No.2017FE467(-146); 2018FE001( -077)]; Bethune ●Lumitin Young Ophthalmology Research Fund ( No. BJ-LM2018009J)
The Second People's Hospital of Yunnan Province; the Fourth Affiliated Hospital of Kunming Medical University; Yunnan Eye Hospital , Kunming 650021, Yunnan Province , China
Correspondence to: Yun-Qin Li. The Second People's Hospital of
Yunnan Province ( The Fourth Affiliated Hospital of Kunming
Medical University; Yunnan Eye Hospital)， Kunming 650021 ,
Yunnan Province，China. liyunqin2004@ 126.com
Received :2019-06-21
Accepted:2019-11-21
Abstract
●Subthreshold micropulse laser ( SML) consists of shortrepetitive pulses of laser. This kind of treatment is safe and cheap, and contrary to conventional laser photocoagulation ( LPC )，SML doesn ’t involve destruction of retinal cells and leave no scars. The possible mechanism of SML is to stimulate retinal pigment epithelium ( RPE) cells for the production of heat shock proteins ( HSPs) and regulate its metabolism and improve its function. The clinical indication of SML includes central serous chorioretinopathy ( CSC)，diabetic retinopathy edema ( DME )， nonproliferative diabetic retinopathy ( NPDR) and proliferative diabetic retinopathy ( PDR) and macular edema ( ME) secondary to retinal vein occlusion ( RVO ). This article discussed the mechanism and safety of SML and reviewed the updates of its application.
KEYWORDS: subthreshold micropulse laser; application; mechanism ; central serous chorioretinopathy; diabetic macular edema; diabetic retinopathy; retinal vein occlusion
Citation: Zhao HK, Zou Y, Li YQ. Process in application of subthreshold micropulse laser. Guoji Yanke Zazhi ( Int Eye Sci ) 2020;20(1) :92-95
