Honghong Zhang1 · Changlin Zhai1 · Huilin Hu1 · Gang Qian1 · Menghui Mao1
Received: 1 November 2025 / Accepted: 18 January 2026©The Author(s) 2026
Abstract
Objective This study aimed to investigate gut microbiota composition and metabolic functions in patients with type 2 diabetes mellitus (DM) complicated by myocardial infarction (MI) and to explore potential mechanisms linking the gut microbiome to MI development.
Methods Sixty patients with DM complicated by MI and 52 patients with DM alone were initially recruited.After quality control, 29 DM +MI patients and 33 DM patients were included in the final analysis. Gut microbial profiles were characterized using shotgun metagenomic sequencing and bioinformatics analyses. Microbial diversity, composition, and gene functions were compared between groups based on KEGG, COG, and CAZy annotations.
Results Overall microbial diversity and metabolic profiles were comparable between the two groups; however, significant differences were observed in specific taxa and functional genes.Taxa enriched in the DM +MI group included Bacteroidales, Prevotellaceae, and Lachnospiraceae. In total, 510 KEGG orthology (KO) units and 21 pathways—including ABC transporters, quorum sensing, and general metabolic pathways—differed significantly between groups. Carbohydrate transport and metabolism, as well as glycoside hydrolase activity, represented the most enriched functional categories. Random forest models based on selected microbial species,KO units, and KEGG pathways achieved areas under the curve (AUCs) of0.868, 0.885, and 0.820, respectively.
Conclusion Patients with DM complicated by MI exhibit distinct gut microbial compositions and functional gene signatures compared with patients with DM alone. These microbiome-based markers may contribute to early risk stratification and provide potential targets for microbiota-focused interventions to mitigate MI risk in patients with diabetes.
Keywords Gut microbiome · Type 2 diabetes mellitus · Myocardial infarction · Metagenomics
Riccardo Magris1 · Andrea Monte1 · NicolòVigolo2 · Francesca Nardello1 · Michele Trinchi1 · Carlo Negri2 · Paolo Gisondi3 · Chiara Cosma4 · Giovanni Sartore4 · Annunziata Lapolla4 · Paolo Moghetti2 · Paola Zamparo1
Received: 17 November 2025 / Accepted: 11 April 2026©The Author(s) 2026
Aims This study aimed to investigate the impact of type 2 diabetes (T2D) on muscle and tendon mechanics by comparing individuals with controlled diabetes to a healthy cohort matched for age, BMI, and physical activity level. A secondary aim was to investigate the possible association between muscle-tendon proprieties and glycated haemoglobin (HbA1c) or advanced glycated end products (AGE, RAGE) as determined in blood and skin biopsies.
Methods Twenty-eight patients and eighteen controls were recruited for this study.Achilles tendon stiffness (kT), muscletendon stiffness (kM, in gastrocnemius medialis) and the rate of torque development (RTD) were evaluated by combining dynamometric and ultrasound data.
Results Diabetic patients showed increased tendon stiffness and reduced tendon elongation compared to controls, but similar RTD and kM values. No differences in advanced glycation end products (in serum or biopsies) were observed between cohorts,but a significant positive correlation was observed between kT and HbA1c (r =0.610,N=46,P<0.001).
Conclusion Our data indicate that muscle, but not tendon, properties can be preserved in controlled and physically active diabetic patients and that higher tendon stiffness does not result in a functional deficit (i.e., same explosive capacity between cohorts).Although this study is cross-sectional and has a limited sample size, our data suggest a potential role of HbA1c as a non-invasive biomarker of altered tendon mechanics in people with diabetes.
ClinicalTrials.gov, protocol number NCT05585502 .
Keywords Advanced glycation end products · Glycated haemoglobin · Tendon stiffness · Muscle stiffness
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
扫一扫了解详情:
任何关于疾病的建议都不能替代执业医师的面对面诊断。所有门诊时间仅供参考，最终以医院当日公布为准。
网友、医生言论仅代表其个人观点，不代表本站同意其说法，请谨慎参阅，本站不承担由此引起的法律责任。
