an Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3
1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China
2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China
3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China
4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China
Correspondence
Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.
Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.
Abstract
Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.
Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).
Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.
Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.
Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.
KEYWORDS
anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle
yatulloh Alquraisy1 , Gofarana Wilar 2 , Ahmed Fouad Abdelwahab Mohammed3 , Ali El-Rayyes4 , Cecep Suhandi 1, Nasrul Wathoni 1
1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Padjadjaran, Sumedang, 45363, Indonesia;
2 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Padjadjaran, Sumedang, 45363, Indonesia; 3 Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt; 4 Department of Chemistry, College of Science, Northern Border University, Arar, Saudi Arabia
Correspondence: Nasrul Wathoni, Email 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Abstract: Various studies have been widely conducted on conditioned medium for the development of anti-aging preparations, including the utilization of stem cells, which present a promising alternative solution. This narrative review aims to understand the latest developments in various conditioned medium stem cell applications for anti-aging on the skin. A search of the Scopus database yielded publications of interest. The research focused on articles published without restrictions on the year. After finding 68 articles in the search results, they moved on to the checking phase. Upon comprehensive literature review, 23 articles met the inclusion criteria, while 45 articles were deemed ineligible for participation in this research. The results of the review indicate that conditioned medium from various stem cells has demonstrated success in reducing risk factors for skin aging, as proven in various tests. The successful reduction of the risk of skin aging has been established in vitro, in vivo, and in clinical trials. Given the numerous studies on the progress of exploring and utilizing conditioned medium, it is expected to provide a solution to the problem of skin aging.
Keywords: conditioned medium, stem cell, anti-aging, skin aging
原创：卢魁
我们经常能看到些步履蹒跚的老年人和些行动不便的中年人， 他们与那些行色匆匆的年轻人形成了鲜明的对比，这些老年人中有一半以上都会受着各种各样的疾病困扰，而最常见的一种就“慢性伤口”。
原创:卢魁
少吃多尝：宴席上丰盛的四高膳食对糖尿病病情控制十分不利，不少糖尿病病人觉得赴宴后血糖会有所升高，所以糖尿病惠者饮食必须控制总热量，一般以低热量、低脂肪、低糖、高纤维膳食为主。面对宴席上的“四高”食品多尝，以免一吃就超量，要像靖蜓点水一样多样化地品尝一点，选择性地少吃一些。这样既饱了口福，也不至于超量。
原创：祝建清
生活中难免磕磕碰碰，跌跌撞撞受伤之后该如何处理伤口呢？红药水、碘酒……这些家庭常备药物看着都眼熟但你分得清什么伤口用什么药吗？处理伤口，药水选哪种好？
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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