伤口世界

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星期一, 09 12月 2019

糖尿病的元凶或是维生素A缺乏？

原创：国际糖尿病 idiabetes

　　长期以来，糖尿病的确切病因一直是未解之谜。近期，一项具有里程碑意义的研究揭示，维生素A对于维持胰腺β细胞功能是至关重要的，维生素A缺乏有可能是糖尿病的病因。

星期一, 09 12月 2019

糖尿病患者不能承受之“肿”

原创： hernanxu 糖尿病天地

当毛细血管损伤或管壁压力增加导致水液从毛细血管进入周围组织，就会出现水肿。糖尿病患者常常存在血液循环问题，使得伤口愈合很慢甚至难以愈合，如果同时伴有水肿，那么伤口的愈合将会变得更加困难。因此，治疗水肿显得至关重要。

星期一, 09 12月 2019

糖尿病神经损伤的危害竟然这么大！

原创： tjx 糖尿病天地

说起糖尿病神经病变，很多人能略知一二，但是神经系统可影响全身各脏器功能，当糖尿病患者出现神经病变，不同人可能会出现不同症状，这些形形色色的神经病变您都了解吗？

星期一, 09 12月 2019

糖尿病患者易于合并的“老年综合征”

原创： tjx 糖尿病天地

疾病之间并不是独立存在的，尤其是糖尿病，如果糖尿病患者不积极控制血糖，可能会导致多种并发症，而各种并发症之间也会有密切的关系，如糖尿病肾病和糖尿病视网膜病变都是糖尿病的微血管并发症，许多糖尿病肾病患者会同时合并有糖尿病眼底病变；如糖尿病肾病患者一般都会出现高血压。

星期一, 09 12月 2019

糖尿病患者如何做好日常足部护理

原创：国际糖尿病

糖尿病患者通常面临哪些足部问题，应该采取哪些日常护理措施？以下让我们来聆听美国田纳西州退伍军人医疗中心足部医疗部门主任Mark Hinkes医生的观点，Hinkes医生还是Healthy Feet for People With Diabetes一书的作者。

星期一, 09 12月 2019

糖尿病蜜月期：我们需要知道什么？

原创：国际糖尿病

　　部分患者初诊为1型糖尿病并开始胰岛素治疗时，其血糖水平正常或接近正常，糖尿病症状消失。即使应用小剂量胰岛素，其血糖水平也近乎正常，有些患者甚至可以暂时停用胰岛素。这种情况被称为“糖尿病蜜月期”。

K2 Content

An evaluation of the effectiveness of ‘ULTRACOL 200′ in enhancing nasolabial fold wrinkles through cutaneous repair 2024-11-25 00:00

Nguyen Ngan Giang1,2 Hyun Ji Kim3 Pham Ngoc Chien2,3 Han Jin Kwon4 Jung Ryul Ham4 Won Ku Lee4 Yeon Ju Gu4 Shou Yi Zhou2,5 Xin Rui Zhang2,5 Sun Young Nam2 Chan Yeong Heo1,2,3,5

1 Department of Medical Device Development, College of Medicine, Seoul National University, Seoul, Republic of Korea

2 Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

3 Korea Institute of Nonclinical Study, H&Bio. co. Ltd., Seongnam, Republic of Korea

4 UltraV Co., Ltd. R&D Center, Seoul, South Korea

5 Department of Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea

Correspondence Sun Young Nam and Chan Yeong Heo, Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 and 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: Injectable filler, a nonsurgical beauty method, has gained popularity in rejuvenating sagging skin. In this study, polydioxanone (PDO) was utilized as the main component of the ULTRACOL200 filler that helps stimulate collagenesis and provide skin radiant effects. The study aimed to evaluate and compare the effectiveness of ULTRACOL200 with other commercialized products in visually improving dermatological problems.

Methods: Herein, 31 participants aged between 20 and 59 years were enrolled in the study. 1 mL of the testing product, as well as the quantity for the compared groups was injected into each participants face side individually. Subsequently, skin texture and sunken volume of skin were measured using ANTERA 3D CS imaging technology at three periods: before the application, 4 weeks after the initial application, and 4 weeks after the 2nd application of ULTRACOL200.

Results: The final results of skin texture and wrinkle volume evaluation consistently demonstrated significant enhancement. Consequently, subjective questionnaires were provided to the participants to evaluate the efficacy of the testing product, illustrating satisfactory responses after the twice applications.

Conclusion: The investigation has contributed substantially to the comprehension of a PDO-based filler (ULTRACOL200) for skin enhancement and provided profound insight for future clinical trials.

KEYWORDS collagen formation, filler, polydioxanone, skin enhancement, Ultracol200
异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病的元凶或是维生素A缺乏？

糖尿病患者不能承受之“肿”

糖尿病神经损伤的危害竟然这么大！

糖尿病患者易于合并的“老年综合征”

糖尿病患者如何做好日常足部护理

糖尿病蜜月期：我们需要知道什么？

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

糖尿病的元凶或是维生素A缺乏？

糖尿病患者不能承受之“肿”

糖尿病神经损伤的危害竟然这么大！

糖尿病患者易于合并的“老年综合征”

糖尿病患者如何做好日常足部护理

糖尿病蜜月期：我们需要知道什么？

消息订阅

学术会议

伤口世界提示