伤口世界

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星期一, 09 9月 2019

小腿伤口难愈合的若干原因

原创：胡海涛负压引流与创面修复

遇到下肢溃疡，如大隐静脉曲张性溃疡、小腿外伤、深静脉血栓后遗症、动脉闭塞性等等，都比较难愈合，原因有以下若干：

星期一, 09 9月 2019

陈国奋

擅长：擅长骨与关节疾病的分期最优化及综合治疗，包括骨创伤、周围神经损伤、退行性骨关节炎、骨质疏松症、强直性脊柱炎及痛风等。在骨与软组织肿瘤领域有较高声誉，包括骨肉瘤的保肢治疗，骨巨细胞瘤的微创治疗，骨转移癌的综合治疗及肿瘤精准医疗领域有独到创新。

星期五, 06 9月 2019

猝死前六个信号要警惕

生命时报中诺医疗

专家介绍：

俞梦越，国家心血管病中心及中国医学科学院阜外医院主任医师、教授、博士生导师，中国临床流行病学会委员，中国公共卫生学会青年委员

近些年来，心脑血管疾病患病率不断上升，猝死的发生率越来越高，不少公众人物如演员高秀敏、古月、马季等都因猝死离世。猝死的主要原因是心源性猝死，包括冠心病或其他恶性心律失常引起的心脏骤停或急性心衰。其中，冠心病导致的猝死可占八成。另外，一些脑血管疾病也会引发猝死。猝死虽然事发突然，实际也是有迹可循的。有心脑血管疾病的高危人群要特别留意几个异常表现，以防止猝死的发生。

星期五, 06 9月 2019

脑血管崩溃前的11大信号！这样预防最科学有效

中诺医疗 来源：凤凰网

缺血性脑卒中和出血性脑卒中，即脑血栓和脑出血，往往会给我们的生活带来毁灭性的打击。一旦脑出血后就会给身体造成巨大伤害，比如半身不遂、甚至昏迷死亡等。专家提醒，脑血管病在发病前，会有很多征兆，但由于症状较轻，很易被人们忽视，特别是对于本身有高血压的人群，下面这11个信号，一定要记住！

星期五, 06 9月 2019

糖尿病为什么可怕？这组漫画说清楚了

中诺医疗声明：本文转载仅作分享。谢谢！

星期五, 06 9月 2019

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

中山一院中诺医疗

中华医学会肾脏病学分会主任委员、中山一院肾内科学科带头人余学清教授指出，慢性肾脏病在我国成年人群中的发病率为10.8%，意味着每十个成年人就有一名是慢性肾脏病患者，这个比例在广东则更高。

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

小腿伤口难愈合的若干原因

陈国奋

猝死前六个信号要警惕

脑血管崩溃前的11大信号！这样预防最科学有效

糖尿病为什么可怕？这组漫画说清楚了

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

小腿伤口难愈合的若干原因

陈国奋

猝死前六个信号要警惕

脑血管崩溃前的11大信号！这样预防最科学有效

糖尿病为什么可怕？这组漫画说清楚了

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

消息订阅

学术会议

伤口世界提示