伤口世界

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星期三, 11 9月 2019

人民日报：医疗最难的不是技术，而是给医生一个冒险的理由

中山二院糖尿病足中心

一位援疆医生讲述了自己的故事：一天夜里，他接诊了一名遭遇车祸的病人，肝脏破裂，生命垂危。虽经全力抢救，病人终因失血过多而死亡。当医生告诉家属这个坏消息后，家属不仅没有责怪医生，反而向医生道谢，然后要求把切下的破碎肝脏带回去，和死者一起埋葬。丧事办完后，家属又来到医院结清所有费用。此举令这位医生十分感动。从此，每当遇到危重患者，他都没有后顾之忧，总是愿意冒险一搏。

星期三, 11 9月 2019

糖尿病足患者足功能的保全（下）

原创：十六点五中山二院糖尿病足中心

如果说大拇指占了人手功能的50%以上的功能，那么足的大趾的功能并没有那么大的作用，实际上，为了追求足底的平面，这三个支撑点的功能都非常重要。

星期三, 11 9月 2019

糖尿病足患者足功能的保全（上）

原创：十六点五中山二院糖尿病足中心

足部对于一个人来说最重要的功能就是站立和行走，这些功能对于一个人来说是非常重要的，没有站立和行走的功能，就意味着这个人无法生活自理，无法工作，需要其他人的照顾，生活质量的急剧下降。

星期三, 11 9月 2019

尾声：2019年版IWGDF有关糖尿病足指南的学习心得（十三）

原创：十六点五中山二院糖尿病足中心

有关糖尿病足这个顽疾，国内外学界最近几年出了很多的指南、专家共识，对于几个比较重要的指南（包括对于2019年版IWGDF糖尿病足指南、2015年版IWGDF糖尿病足指南、中华医学会糖尿病分会糖尿病足及周围血管病变学组等）进行研读之后，有这么几个印象。

星期三, 11 9月 2019

糖尿病足的分类（下）：2019年版IWGDF有关糖尿病足指南的学习心得（十二）

原创：十六点五中山二院糖尿病足中心

2019年版IWGDF有关糖尿病足指南特别推荐的SINBAD系统是指对糖尿病足以下的一些指标进行评价后的分类：Site(位置)、Ischemia(缺血)、Neuropathy(神经病变)、Bacterial infection(细菌感染)、Area(面积)、Depth(深度)。

星期三, 11 9月 2019

糖尿病足的分类：2019年版IWGDF有关糖尿病足指南的学习心得（十一）

原创：十六点五中山二院糖尿病足中心

有时候，作为一个西医生，不得不感慨西方学者和东方学者之间思维定势的差别，当阅读到2019年版IWGDF糖尿病足指南中非常隆重的专列了一章糖尿病足溃疡的分类（IWGDF Guideline on the classification of diabetic foot ulcers）的时候，不得不佩服西方学者对某个事物分类的执着和重视。

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

人民日报：医疗最难的不是技术，而是给医生一个冒险的理由

糖尿病足患者足功能的保全（下）

糖尿病足患者足功能的保全（上）

尾声：2019年版IWGDF有关糖尿病足指南的学习心得（十三）

糖尿病足的分类（下）：2019年版IWGDF有关糖尿病足指南的学习心得（十二）

糖尿病足的分类：2019年版IWGDF有关糖尿病足指南的学习心得（十一）

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

人民日报：医疗最难的不是技术，而是给医生一个冒险的理由

糖尿病足患者足功能的保全（下）

糖尿病足患者足功能的保全（上）

尾声：2019年版IWGDF有关糖尿病足指南的学习心得（十三）

糖尿病足的分类（下）：2019年版IWGDF有关糖尿病足指南的学习心得（十二）

糖尿病足的分类：2019年版IWGDF有关糖尿病足指南的学习心得（十一）

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学术会议

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