伤口世界

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星期一, 09 9月 2019

关爱癌性伤口患者，努力让他们活得更有尊严

原创：胡海涛负压引流与创面修复

癌性伤口，给患者的伤痛难于安抚，他们活在癌症与伤口疼痛双重压力下，连正常洗澡权力可能被剥夺了，是苦不堪言。

过去处理过颈部巨大癌性溃疡、会阴部巨大溃疡、腹部癌性肠瘘，虽然没能把他们治愈，但是通过专业处理，他们在离世之前获得了最后的尊严。

星期一, 09 9月 2019

7天治愈颈部脓肿——从切开到愈合！

原创：胡海涛负压引流与创面修复

女性患者，29岁，因为害怕手术，颈部包块肿痛1月，一直保守治疗，超声示左侧颈前区脓肿，一周后需要出国旅游，提出‘一周可以治愈吗’？

星期一, 09 9月 2019

感染性皮脂腺囊肿的负压引流经验分享

原创：胡海涛负压引流与创面修复

前言：皮脂腺囊肿，是一个常见疾病，如果不痛不痒时治疗，直接切除它，一期缝合，一周可以痊愈！感染后就医，是一个麻烦疾病，如果合并糖尿病，更是雪上加霜，痛苦持续少则半个月，多着一个月！

星期一, 09 9月 2019

纱布致医疗事故敲响警钟----警惕伤口窦道遗物残留！

原创：胡海涛负压引流与创面修复

攀枝花市卫生计生委，依据《中华人民共和国执业医师法》《医疗事故处理条例》等相关法律法规，责令西区卫生计生局对承担主要责任的攀枝花宏实医院及其涉责医务人员作出处理：吊销攀枝花宏实医院《医疗机构执业许可证》；吊销主持术前讨论和手术主刀的医生文莉琼《医师执业证书》；吊销器械护士苏阿芹《护士执业证书》；吊销巡回护士周燕《护士执业证书》；暂停参与术前讨论的医生胡晓峰执业活动。

伤口爱好者，如何避免，如何避免不发生在自己身上?

星期一, 09 9月 2019

纱布做负压引流材料，治愈的一例骶尾部褥疮

原创：无限di渴望负压引流与创面修复

套装VSD价格昂贵:让很多患者望而却步，同时也让很多医护人员退避三舍！

星期一, 09 9月 2019

压疮患者，可以给他或她流水洗澡吗？

原创：胡海涛负压引流与创面修复

现实：褥疮患者入院时，脏、脏、很脏，也很恶臭，他们的亲人也是捂着鼻子远远的站着，看到这个患者，就能知道他一定是色、臭、味俱全！

K2 Content

异体表皮干细胞对裸鼠全层皮肤缺损创面移植异体全厚皮成活的影响及其机制 2024-11-22 00:00

黄韶斌 1 胡志成 1 张逸 2 唐冰 1 王鹏 1 徐海琳 1 王志勇 1 董云先 1 程璞 1 荣燕超 1 吴军 3 朱家源 1

1 中山大学附属第一医院烧伤科，广州 510080；

2 南通大学附属医院烧伤整形外科 226001；3 深圳大学第一附属医院烧伤整形科 518037 通信作者：朱家源，Email：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Novel Cosmetic Ingredient CS-AA Polyion Complex and Skin Moisturizing Effect 2024-11-20 00:00

Hyungjoon Jeon Yong Won Shin Jong Gu Won Nojin Park Sang-Wook Park Nam Seo Son Mi-Sun Kim

LG Household & Health Care (LG H&H), LG Science Park R&D Center, Seoul, Republic of Korea

Correspondence: Hyungjoon Jeon (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) Mi-Sun Kim (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 29 January 2024

Revised: 21 June 2024

Accepted: 19 July 2024

Keywords: arginine | chondroitin sulfate | glutamine | skin hydration | TEWL | water-holding capacity

ABSTRACT

Purpose: The study explored the enhanced skin moisturizing capabilities and moisture retention effects achieved by forming a polyion complex using sulfated glycosaminoglycan (GAG), specifically chondroitin sulfate (CS), and amino acids (AA) such as glutamine (Q) and arginine (R). The overall hydration effect of this CS-AA complex was examined.

Methods: After analyzing the CS-AA polyion complex structure using spectroscopic methods, the ex vivo moisture retention ability was assessed under dry conditions using porcine skin samples. Additionally, the efficacy of the CS-AA polyion complex in reducing transepidermal water loss (TEWL) and improving skin hydration was evaluated on human subjects using a digital evaporimeter and a corneometer, respectively.

Results: Validating a systematic reduction in particle size, the following order was observed: CS > CS/AA simple mixture > CSAA complex based on dynamic light scattering (DLS) and transmission electron microscopy (TEM) analysis. Furthermore, observations revealed that the CS-AA complex exhibits negligible surface charge. Additionally, Fourier-transform infrared spectroscopy (FT-IR) analysis demonstrated a distinct peak shift in the complex, confirming the successful formation of the CS-AA complex. Subsequently, the water-holding effect through porcine skin was assessed, revealing a notable improvement in moisture retention (weight loss) for the CS-Q complex: 40.6% (1 h), 20.5% (2 h), and 18.7% (4 h) compared to glycerin. Similarly, the CS-R complex demonstrated enhancements of 50.2% (1 h), 37.5% (2 h), and 33% (4 h) compared to glycerin. Furthermore, TEWL improvement efficacy on human skin demonstrated approximately 25% improvement for both the CS-Q complex and CS-R complex, surpassing the modest 12.5% and 18% improvements witnessed with water and glycerin applications, respectively. Finally, employing a corneometer, hydration changes in the skin were monitored over 4 weeks. Although CS alone exhibited nominal alterations, the CS-Q complex and CS-R complex showed a significant increase in moisture levels after 4 weeks of application.

Conclusion: In this study, polyion complexes were successfully formed between CS, a sulfated GAG, and AA. Comparisons with glycerin, a well-known moisturizing agent, confirmed that the CS-AA complex exhibits superior moisturizing effects in various aspects. These findings suggest that the CS-AA complex is a more effective ingredient than CS or AA alone in terms of efficacy.
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream 2024-11-19 00:00

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

关爱癌性伤口患者，努力让他们活得更有尊严

7天治愈颈部脓肿——从切开到愈合！

感染性皮脂腺囊肿的负压引流经验分享

纱布致医疗事故敲响警钟----警惕伤口窦道遗物残留！

纱布做负压引流材料，治愈的一例骶尾部褥疮

压疮患者，可以给他或她流水洗澡吗？

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

关爱癌性伤口患者，努力让他们活得更有尊严

7天治愈颈部脓肿——从切开到愈合！

感染性皮脂腺囊肿的负压引流经验分享

纱布致医疗事故敲响警钟----警惕伤口窦道遗物残留！

纱布做负压引流材料，治愈的一例骶尾部褥疮

压疮患者，可以给他或她流水洗澡吗？

消息订阅

学术会议

伤口世界提示