伤口世界

电子邮件地址: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

星期一, 09 9月 2019

陈国奋

擅长：擅长骨与关节疾病的分期最优化及综合治疗，包括骨创伤、周围神经损伤、退行性骨关节炎、骨质疏松症、强直性脊柱炎及痛风等。在骨与软组织肿瘤领域有较高声誉，包括骨肉瘤的保肢治疗，骨巨细胞瘤的微创治疗，骨转移癌的综合治疗及肿瘤精准医疗领域有独到创新。

星期五, 06 9月 2019

猝死前六个信号要警惕

生命时报中诺医疗

专家介绍：

俞梦越，国家心血管病中心及中国医学科学院阜外医院主任医师、教授、博士生导师，中国临床流行病学会委员，中国公共卫生学会青年委员

近些年来，心脑血管疾病患病率不断上升，猝死的发生率越来越高，不少公众人物如演员高秀敏、古月、马季等都因猝死离世。猝死的主要原因是心源性猝死，包括冠心病或其他恶性心律失常引起的心脏骤停或急性心衰。其中，冠心病导致的猝死可占八成。另外，一些脑血管疾病也会引发猝死。猝死虽然事发突然，实际也是有迹可循的。有心脑血管疾病的高危人群要特别留意几个异常表现，以防止猝死的发生。

星期五, 06 9月 2019

脑血管崩溃前的11大信号！这样预防最科学有效

中诺医疗 来源：凤凰网

缺血性脑卒中和出血性脑卒中，即脑血栓和脑出血，往往会给我们的生活带来毁灭性的打击。一旦脑出血后就会给身体造成巨大伤害，比如半身不遂、甚至昏迷死亡等。专家提醒，脑血管病在发病前，会有很多征兆，但由于症状较轻，很易被人们忽视，特别是对于本身有高血压的人群，下面这11个信号，一定要记住！

星期五, 06 9月 2019

糖尿病为什么可怕？这组漫画说清楚了

中诺医疗声明：本文转载仅作分享。谢谢！

星期五, 06 9月 2019

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

中山一院中诺医疗

中华医学会肾脏病学分会主任委员、中山一院肾内科学科带头人余学清教授指出，慢性肾脏病在我国成年人群中的发病率为10.8%，意味着每十个成年人就有一名是慢性肾脏病患者，这个比例在广东则更高。

星期五, 06 9月 2019

北大医院：糖尿病有救了打太极拳可明显改善

太极拳中诺医疗

太极拳能治糖尿病？

糖尿病——严重危害人类健康，是现代疾病中的一大杀手，对人体的危害仅次于肿瘤和心脑血管病。据估计，Ⅱ型糖尿病病人在全世界有两亿五千万人。在我国，它已超越高血压人群、成为第一大高发疾病。其中2型糖尿病约占糖尿病总数的90％～95％。

K2 Content

The efcacy of hyaluronic acid fragments with amino acid in combating facial skin aging: an ultrasound and histological study 2024-11-05 00:00

Antonio Scarano1 · E. Qorri2 · A. Sbarbati3 · S. A. Gehrke4 · Alessio Frisone1 · D. Amuso3 · Sergio Rexhep Tari1

Received: 30 March 2024 / Accepted: 17 May 2024 / Published online: 24 June 2024

© The Author(s) 2024

Antonio Scarano

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

E. Qorri

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

A. Sbarbati

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

S. A. Gehrke

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

D. Amuso

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Sergio Rexhep Tari

该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

1 Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Strada Marcello Mucci 38/B, 66100 Chieti, Italy

2 Department of Dentistry, Faculty of Medical Sciences, Albanian University, 1001 Tirana, Albania

3 Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, School of Medicine, University of Verona, Verona, Italy

4 Department of Research, Bioface/PgO/UCAM, Montevideo, Uruguay

Abstract

Background Various techniques have been employed in aesthetic medicine to combat skin aging, in particular that of the facial region. Hyaluronic acid is utilized to enhance moisture levels and extracellular matrix molecules. This study aims to histologically assess the efects of low molecular weight hyaluronic acid fragments combined with amino acids (HAAM) on facial skin rejuvenation through intradermal microinjections.

Methods A total of twenty women, with an average age of 45 and ranging from 35 to 64 years old, participated in the study, including 8 in menopause and 12 in the childbearing age group. Mesotherapy was used to administer HAAM to the patients. Prior to and three months after the treatment, each patient underwent small circular punch biopsies. Ultrasound examinations were conducted using B-mode, capturing 2D images in longitudinal or transverse orientations with frequencies ranging from 5 to 13 Mega-hertz (MY LAB X8, ESAOTE, Genova, Italy). A total of 60 ultrasound examinations were taken, with 30 collected before treatment and 30 after treatment.

Results The histological analysis demonstrates an increase in fbroblast activity resulting in the production of Type III reticular collagen, as well as an increased number of blood vessels and epidermal thickness. However, the analysis of ultrasound data before and after treatment showed no statistical diference in skin thickness in malar area, chin and mandibular angle.

Conclusions Histological assessments indicate that subcutaneous infltration of HAAM has a substantial impact on the dermis of facial skin.

Keywords Hyaluronic acid · Hyaluronic acid fragments · Amino acid · Fibroblast · Skin aging · Ultrasound
GLP1R Gene Expression and Kidney Disease Progression 2024-11-04 00:00

Jefferson L. Triozzi, MD, MSCI; Zhihong Yu, MS, PhD; Ayush Giri, MS, PhD; Hua-Chang Chen, PhD; Otis D. Wilson, BBA; Brian Ferolito, MS; T. Alp Ikizler, MD; Elvis A. Akwo, MD, MS; Cassianne Robinson-Cohen, PhD; John Michael Gaziano, MD, MPH; Kelly Cho, PhD, MPH; Lawrence S. Phillips, MD; Ran Tao, PhD; Alexandre C. Pereira, MD, PhD; Adriana M. Hung, MD, MPH; for the VA Million Veteran Program

Key Points

Question Are glucagon-like peptide 1 receptor agonists (GLP-1RAs) associated with kidney disease progression?

Findings In this genetic association study of 353 153 adults, higher genetic GLP1R gene expression as a proxy for GLP-1RAs was associated with a small reduction in the risk of kidney disease progression, even after adjusting for obesity and diabetes.

Meaning These findings support a nephroprotective role of GLP-1RAs.

Abstract

IMPORTANCE Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have nephroprotective properties beyond those related to weight loss and glycemic control.

OBJECTIVE To investigate the association of genetically proxied GLP-1RAs with kidney disease

DESIGN, SETTING, AND PARTICIPANTS This genetic association study assembled a national retrospective cohort of veterans aged 18 years or older from the US Department of Veterans Affairs Million Veteran Program between January 10, 2011, and December 31, 2021. Data were analyzed from November 2023 to February 2024.

EXPOSURES Genetic risk score for systemic GLP1R gene expression that was calculated for each study participant based on genetic variants associated with GLP1R mRNA levels across all tissue samples within the Genotype-Tissue Expression project.

MAIN OUTCOMES AND MEASURES The primary composite outcome was incident end-stage kidney disease or a 40% decline in estimated glomerular filtration rate. Cox proportional hazards regression survival analysis assessed the association between genetically proxied GLP-1RAs and kidney disease progression.

RESULTS Among 353 153 individuals (92.5% men), median age was 66 years (IQR, 58.0-72.0 years) and median follow-up was 5.1 years (IQR, 3.1-7.2 years). Overall, 25.7% had diabetes, and 45.0% had obesity. A total of 4.6% experienced kidney disease progression. Overall, higher genetic GLP1R gene expression was associated with a lower risk of kidney disease progression in the unadjusted model (hazard ratio [HR], 0.96; 95% CI, 0.92-0.99; P = .02) and in the fully adjusted model accounting for baseline patient characteristics, body mass index, and the presence or absence of diabetes (HR, 0.96; 95% CI, 0.92-1.00; P = .04). The results were similar in sensitivity analyses stratified by diabetes or obesity status.

CONCLUSIONS AND RELEVANCE In this genetic association study, higher GLP1R gene expression was associated with a small reduction in risk of kidney disease progression. These findings support pleiotropic nephroprotective mechanisms of GLP-1RAs independent of their effects on body weight and glycemic control.
Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations 2024-10-31 00:00

Daniela Milosheska . Robert Roskar

Received: August 17, 2022 / Accepted: September 6, 2022 / Published online: October 11, 2022

©The Author(s) 2022

ABSTRACT

Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are one of the most popular ingredients used in antiaging treatments. Among the representatives of retinoids, tretinoin is considered the most effective agent with proven antiaging effects on the skin and can be found in formulations approved as medicines for topical treatment of acne, facial wrinkles, and hyperpigmentation. Other retinoids present in topical medicines are used for various indications, but only tazarotene is also approved as adjunctive agent for treatment of facial fine wrinkling and pigmentation. The most commonly used retinoids such as retinol, retinaldehyde, and retinyl palmitate are contained in cosmeceuticals regulated as cosmetics. Since clinical efficacy studies are not required for marketing cosmetic formulations, there are concerns about the efficacy of these retinoids.

From a formulation perspective, retinoids pose a challenge to researchers as a result of their proven instability, low penetration, and potential for skin irritation. Therefore, novel delivery systems based on nanotechnology are being developed to overcome the limitations of conventional formulations and improve user compliance. In this review, the clinical evidence for retinoids in conventional and nanoformulations for topical antiaging treatments was evaluated. In addition, an overview of the comparison clinical trials between tretinoin and other retinoids is presented. In general, there is a lack of evidence from properly designed clinical trials to support the claimed efficacy of the most commonly used retinoids as antiaging agents in cosmeceuticals. Of the other retinoids contained in medicines, tazarotene and adapalene have clinically evaluated antiaging effects compared to tretinoin and may be considered as potential alternatives for antiaging treatments. The promising potential of retinoid nanoformulations requires a more comprehensive evaluation with additional studies to support the preliminary findings.

Keywords: Antiaging; Clinical evidence; Cosmeceuticals; Nanoformulations; Retinoids; Retinol; Tretinoin

Key Summary Points

Tretinoin is the retinoid present in medicines for topical application with the strongest clinical evidence of antiaging Tazarotene and adapalene may be considered as tretinoin alternatives for antiaging treatments.

Clinical evidence is lacking for retinoids contained in cosmeceuticals for topical antiaging treatments.

Novel formulations based on nanotechnology are being developed to overcome the major drawbacks of retinoid Further evaluation with in vivo testing and clinical trials are needed to support the preclinical results for the developed nanoformulations containing retinoids.

D. Milosheska INSLAB, Maribor, Slovenia

R. Roskar (&)

University of Ljubljana, Faculty of Pharmacy, Askerceva cesta 7, 1000 Ljubljana, Slovenia

e-mail: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

陈国奋

猝死前六个信号要警惕

脑血管崩溃前的11大信号！这样预防最科学有效

糖尿病为什么可怕？这组漫画说清楚了

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

北大医院：糖尿病有救了打太极拳可明显改善

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

陈国奋

猝死前六个信号要警惕

脑血管崩溃前的11大信号！这样预防最科学有效

糖尿病为什么可怕？这组漫画说清楚了

10个成年人中就有一个得肾病，生活中常被忽视的6个伤肾小细节，特别是第6个！

北大医院：糖尿病有救了 打太极拳可明显改善

消息订阅

学术会议

伤口世界提示

北大医院：糖尿病有救了打太极拳可明显改善