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O.Zmora1 · Y. Stark2 · O. Belotserkovsky2 · M. Reichert2 · G. A. Kozloski2 · N. Wasserberg3 · H. Tulchinsky4 · L. Segev5 · A.J. Senagore2 · N. Emanuel2
Received: 11 May 2022 / Accepted: 16 August 2022 / Published online: 1 September 2022
© The Author(s) 2022
A. J. Senagore
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1 Shamir Medical Center, Be’er Ya’akov, Israel
2 PolyPid Ltd, Petach Tikvah, Israel
3 Rabin Medical Center, Beilinson Campus, Petach Tikva,
Israel
4 Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel
5 Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel
Abstract
Background Despite significant advances in infection control guidelines and practices, surgical site infections (SSIs) remain a substantial cause of morbidity, prolonged hospitalization, and mortality among patients having both elective and emergent surgeries. D-PLEX100 is a novel, antibiotic-eluting polymer–lipid matrix that supplies a high, local concentration of doxycycline for the prevention of superficial and deep SSIs. The aim of our study was to evaluate the safety and efficacy of D-PLEX in addition to standard of care (SOC) in preventing superficial and deep surgical site infections for patients undergoing elective colorectal surgery.
Methods From October 10, 2018 to October 6, 2019, as part of a Phase 2 clinical trial, we randomly assigned 202 patients who had scheduled elective colorectal surgery to receive either standard of care SSI prophylaxis or D-PLEX100 in addition to standard of care. The primary objective was to assess the efficacy of D-PLEX100 in superficial and deep SSI reduction, as measured by the incidence of SSIs within 30 days, as adjudicated by both an individual assessor and a three-person endpoint adjudication committee, all of whom were blinded to study-group assignments. Safety was assessed by the stratification and incidence of treatment-emergent adverse events.
Results One hundred and seventy-nine patients were evaluated in the per protocol population, 88 in the intervention arm [51 males, 37 females, median age (64.0 range: 19–92) years] and 91 in the control arm [57 males, 34 females, median age 64.5 (range: 21–88) years]. The SSI rate within 30 day post-index surgery revealed a 64% relative risk reduction in SSI rate in the D-PLEX100 plus standard of care (SOC) group [n=7/88 (8%)] vs SOC alone [n=20/91 (22%)]; p=0.0115. There was no significant difference in treatment-emergent adverse events.
Conclusions D-PLEX100 application leads to a statistically significant reduction in superficial and deep surgical site infections in this colorectal clinical model without any associated increase in adverse events.
Keywords Surgical site infection · Localized antibiotic therapy · Doxycycline
P.Calò1 · F. Catena2 · D. Corsaro3 · L. Costantini4 · F. Falez5 · B. Moretti6 · V. Parrinello7 · E. Romanini8,9 · A. Spinarelli10 · G. Vaccaro11,12· F. Venneri13
Received: 27 December 2022 / Accepted: 26 January 2023
Published online:13 February 2023
© The Author(s) 2023 OPEN
G. Vaccaro, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 | 1 University Teaching Hospital of Cagliari and Surgical Department at University of Cagliari, Cagliari, Italy. 2 Department General and Emergency Surgery at Bufalini Hospital, Cesena, Italy. 3 International Research at BHAVE, Via GiambattistaVico 1, 00196 Rome, Italy. 4 Department of Medical and Surgical Sciences, School of Community Medicine and Primary Care, University of Modena and Reggio Emilia, Modena, Italy. 5 Department of Orthopaedics ASL Roma 1 and Director UOC Orthopaedics Hospital San Filippo Neri, Rome, Italy. 6 Orthopedics and Traumatology Complex Operative Unit, University Teaching Hospital of Bari Polyclinic, Bari, Italy. 7 Operative Unit of Quality and Clinical Risk Manager at “G.Rodolico-San Marco” University Teaching Hospital in Catania, Catania, Italy. 8 SIOT Guidelines Commission, Rome, Italy. 9 Complex Operative Unit of Orthopedics and Traumatology at University Teaching Hospital of Bari Polyclinic, Bari, Italy. 10Operative Unit of Orthopedics and Traumatology at University Teaching Hospital of Bari Polyclinic, Bari, Italy. 11Social, Epidemiological and Outcome Research at BHAVE, Via Giambattista Vico 1, 00196 Rome, Italy. 12Sociologist UO Education and Health Promotion, Asp Catania, Via Santa Maria la Grande 5, 95124 Catania, Italy. 13Simple Structure Clinical Risk and Surgical Emergency in Florence, Florence, Italy.
Abstract
Surgical site infections (SSI) are the leading cause of hospital readmission after surgical procedures with significant impact on post-operative morbidity and mortality. Modifiable risk factors for SSI include procedural aspects, which include the possibility of instrument contamination, the duration of the operation, the number of people present and the traffic in the room and the ventilation system of the operating theatre.The aim of this systematic review was to provide literature evidence on the relationship between features of surgical procedure sets and the frequency of SSI in patients undergoing surgical treatment, and to analyse how time frames of perioperative processes and operating theatre traffic vary in relation to the features of the procedure sets use, in order tooptimise infection control in OT. The results of the systematic review brought to light observational studies that can be divided into two categories: evidence of purely clinical significance and evidence of mainly organisational, managerial and financial significance. These two systems are largely interconnected, and reciprocally influence each other. The decision to use disposable devices and instruments has been accompanied by a lower incidence in surgical site infections and surgical revisions for remediation. A concomitant reduction in post-operative functional recovery time has also been observed. Also, the rationalisation of traditional surgical sets has also been observed in conjunction with outcomes of clinical significance.
Pranav Jani1,2 · Umesh Mishra1,2 · Julia Buchmayer3 · Rajesh Maheshwari1,2 · Daphne D’Çruz2 · Karen Walker1,4,5,6,7 · Duygu Gözen8 · Krista Lowe2 · Audrey Wright2 · James Marceau2 · Mihaela Culcer1,2 · Archana Priyadarshi1,2 · Adrienne Kirby9 · James E. Moore10,11 · Ju Lee Oei12,13 · Vibhuti Shah14 · Umesh Vaidya15 · Abdelmoneim Khashana16 · Sunit Godambe17 · Fook Choe Cheah18,19 · Wen‑Hao Zhou20 · Xiao‑Jing Hu21 · Muneerah Satardien22,23
Received: 28 July 2022 / Accepted: 19 September 2022 / Published online: 13 November 2022 © The Author(s) 2022
Abstract
Background Globally, are skincare practices and skin injuries in extremely preterm infants comparable? This study describes skin injuries, variation in skincare practices and investigates any association between them.
Methods A web-based survey was conducted between February 2019 and August 2021. Quantifying skin injuries and describing skincare practices in extremely preterm infants were the main outcomes. The association between skin injuries and skincare practices was established using binary multivariable logistic regression adjusted for regions.
Results Responses from 848 neonatal intensive care units, representing all geographic regions and income status groups were received. Diaper dermatitis (331/840, 39%) and medical adhesive-related skin injuries (319/838, 38%) were the most common injuries. Following a local skincare guideline reduced skin injuries [medical adhesive-related injuries: adjusted odds ratios (aOR)=0.63, 95% confidence interval (CI)=0.45–0.88; perineal injuries: aOR=0.66, 95% CI=0.45–0.96; local skin infections: OR=0.41, 95% CI=0.26–0.65; chemical burns: OR=0.46, 95% CI=0.26–0.83; thermal burns: OR=0.51, 95% CI=0.27–0.96]. Performing skin assessments at least every four hours reduced skin injuries (abrasion: aOR=0.48, 95% CI=0.33–0.67; pressure: aOR=0.51, 95% CI=0.34–0.78; diaper dermatitis: aOR=0.71, 95% CI=0.51–0.99; perineal: aOR=0.52, 95% CI=0.36–0.75). Regional and resource settings-based variations in skin injuries and skincare practices were observed.
Conclusions Skin injuries were common in extremely preterm infants. Consistency in practice and improved surveillance appears to reduce the occurrence of these injuries. Better evidence regarding optimal practices is needed to reduce skin injuries and minimize practice variations.
Keywords Extremely premature infants · Injuries · Neonatal intensive care unit · Skin care · Wounds
Pranav Jani
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Extended author information available on the last page of the article
Mireille Dekker1*, Irene P. Jongerden2 , Martine G. Caris1 , Martine C. de Bruijne2 , Christina M. J. E. Vandenbroucke‑Grauls1,3 and Rosa van Mansfeld1
*Correspondence:
Mireille Dekker
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1 Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands
2 Department of Public and Occupational Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands
3 Department of Clinical Medicine – Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark
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Abstract
Background Important elements of programs that train and support infection control link nurses (ICLN) are the engagement of stakeholders, support from hospital and ward management and a structure for iterative improvement. The effects of programs, that combine all these elements, are unknown. We evaluated such a comprehensive program to explore its impact on link nurses and infection prevention practices and routines.
Methods We used the RE-AIM framework, a robust, evidence-based framework within the field of Implementation Science, to evaluate the impact of our ICLN training and support program. We used a mixed methods approach and organized the outcomes along its five dimensions: Reach, Effectiveness, Adoption, Implementation and Maintenance.
Results Between 2014 and 2018, on average 91% of the inpatient wards and 58% of the outpatient clinics participated in the program (Reach) and impacted guideline adherence in inpatient wards. Link nurses felt engaged and empowered, and perceived their contribution to these results as pivotal. Ward managers confirmed the value of ICLN to help with implementing IPC practices (Effectiveness). The program was adopted both at the hospital and at the ward level (Adoption). Based on ongoing evaluations, the program was adapted by refining education, training and support strategies with emphasis on ward specific aspects (Implementation). The ICLN program was described as a key component of the infection prevention policy to sustain its effects (Maintenance).
Conclusions Our infection control link nurse program helped ICLN to improve infection prevention practices, especially in inpatient wards. The key to these improvements lay within the adaptability of our link nurse program. The adjustments to the program led to a shift of focus from hospital goals to goals tailored to the ward level. It allowed us to tailor activities to align them with the needs specific to each ward.
Keywords Quality improvement, Patient safety, Nursing practice, Nosocomial infections, Infection prevention