Tim Mori1,2 · Katsiaryna Prystupa2,3 · Klaus Straßburger1,2 · Marc Bonn2,4 · Oana Patricia Zaharia2,3,5 · Olaf Spörkel2,4 · Oliver Kuß1,2,6 · Michael Roden2,3,5 · Robert Wagner2,3,5
Received: 10 December 2024 / Accepted: 13 December 2024 / Published online: 17 January 2025 © The Author(s) 2025
Chiara M. Soldavini1 · Gabriele Piuri1 · Paola A. Corsetto2 · Irma Colombo2 · Veronica Resi3 · Stefania Zava2 · Gabriele Rossi1 · Enrico Ferrazzi1,4 · Angela M. Rizzo2
Received: 27 December 2024 / Accepted: 2 March 2025 / Published online: 1 April 2025 © The Author(s) 2025
Abstract
Normal pregnancy is characterized by changes in lipid metabolism with significant implications for the health of both mother and offspring. When these changes develop into maternal dyslipidemia, a significant association with adverse pregnancy outcomes has been observed, including the development of gestational diabetes (GD), modulation of the inflam-matory response, and excessive fetal growth. In the present study, we performed a lipidomic assessment of patients at GD diagnosis (24–28 weeks of gestation) and 12 weeks after diagnosis. We found higher levels of esterified oleic acid in plasma at the time of GD diagnosis in women who subsequently required pharmacological therapy to control blood glu-cose levels compared to those who did not require additional treatment, suggesting that the measurement of plasma oleic acid might be an additional tool for the early identification of patients with a more severe form of gestational diabetes. Moreover, plasma oleic acid levels showed a positive correlation with fetal growth in the context of adequate glycemic control, supporting a metabolic dysregulation of other pathways whose identification could help clinicians to discriminate different cases within the spectrum of severity of the disease. Finally, the correlation between plasma oleic acid and circu-lating BAFF levels at the time of diagnosis and 12 weeks later adds a possible mechanism to support the pro-inflammatory and pro-diabetic state in the metabolic set of GD. Overall, these findings strongly support the role of plasma oleic acid as a possible early marker for GD severity stratification during pregnancy.
Keywords Gestational diabetes · Lipidomics · Oleic acid · Fatty acid · Pregnancy inflammation · Biomarker
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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