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    Custom Mod Mega1

    主任医师、教授、博导,南方医科大学第三附属医院(广东省骨科医院)院长

    • 中德骨科伤口管理学校校长
    • 广东省骨科研究院运动医学研究所所长
    • 广东省内运动医学专业唯一的博士研究生导师
    • 美国哈弗大学医学院骨科访问学者
    • 专业特长处于省内领先、国内或国际先进水平以上
    • 2018年获得“国之名医卓越建树”荣誉称号
    • 2017年被评为全国卫生计生系统先进工作者、广东省医学领军人才
    • 中国医师协会运动医师分会副会长
    • STCOT中国部运动医学分会副主任委员
    • 广东省医学会关节外科分会主任委员
    • 广东省医学会运动医学会分会名誉主任委员
    • 独立承担过国家“863”课题,主持过10余项省、部级科研项目
    • 多份专业杂志编委
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    • 寻常痤疮临床严重度分级及疗效评价 中国专家共识(2025版) 2026-06-09 00:00

      中国医师协会皮肤科医师分会痤疮学组 中国研究型医院学会皮肤科学专业委员会 中国中西医结合学会皮肤性病专业委员会痤疮学组 通信作者:鞠强,Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。;顾恒,Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。;郑志忠, Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

      【摘要】 寻常痤疮(简称痤疮)是皮肤科常见的损容性皮肤病,临床表现多样。痤疮存在多种临 床严重度分级方法,但如何客观地评价疾病严重程度并用于指导痤疮治疗方案的选择,以及如何科 学评价各种治疗方式在痤疮治疗中的疗效目前仍缺乏统一标准,也是临床医生极为关注的问题。为此,中国医师协会皮肤科医师分会痤疮学组、中国研究型医院学会皮肤科学专业委员会、中国中西医结合学会皮肤性病专业委员会痤疮学组组织我国痤疮诊疗领域部分专家,在广泛讨论的基础上制订《寻常痤疮临床严重度分级及疗效评价中国专家共识》,供皮肤科医师临床应用参考。【关键词】 寻常痤疮;治疗;严重度分级;疗效评价;专家共识 DOI:10.35541/cjd.20250034

      Chinese expert consensus on clinical severity grading and therapeutic evaluation of acne vulgaris (2025 edition)

      Acne Study Group of China Dermatologist Association; Dermatology Professional Committee of Chinese Research Hospital Association; Acne Study Group of Dermatology and Venereology Professional Committee of Chinese Association of Integrative Medicine

      Corresponding authors: Ju Qiang, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Gu Heng, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Zheng Zhizhong, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

      【Abstract】 Acne vulgaris (abbreviated as acne) is a common aesthetic ⁃ impairing dermatological disease that markedly affects appearance, and is characterized by diverse clinical manifestations. At present, there are various grading systems for acne severity, while there is still a lack of unified standards for objectively assessing disease severity to guide treatment selection and scientifically evaluating the efficacy of acne therapies, which are also highly concerned issues for clinicians. To address this, the Acne Study Group of China Dermatologist Association, the Dermatology Professional Committee of Chinese Research Hospital Association, and the Acne Study Group of Dermatology and Venereology Professional Committee of Chinese Association of Integrative Medicine organized a group of experts in the field of acne diagnosis and treatment in China to develop the "Chinese expert consensus on clinical severity grading and therapeutic evaluation of acne vulgaris" after extensive discussions, aiming to provide a reference for dermatologists in clinical practice.

      【Key words】 Acne vulgaris; Treatment; Clinical severity grading; Therapeutic evaluation; Expert consensus DOI: 10.35541/cjd.20250034

    • Comprehensive Approaches to Diagnosis and Treatment of Sensitive Skin 2026-06-08 00:00

      Hye One Kim 1,* , Ji Young Um 1,* , Han Bi Kim 1 , So Yeon Lee 1 , Hyun Choi 2 , Jihye Kim 3 , Eunbi Ko 3 , Bo Young Chung 1 , Chun Wook Park 1

      1 Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea

      2 Make-up Lab, R&D Center, Kolmar Korea, Seoul, Korea

      3 Clinical Research Lab, Amorepacific R&I Center, Yongin, Korea

      ABSTRACT

      Sensitive skin (SS) is increasingly recognized as a complex syndrome characterized by discom-fort and heightened sensitivity to otherwise harmless stimuli, such as environmental changes, physical contact, and cosmetic products. This condition poses challenges in both diagnosis and treatment due to its variable presentation and subjective nature. The pathophysiological features of SS include neurogenic inflammation and small fiber neuropathy, largely driven by the hyperactivation of sensory nerves. This hyperactivation is closely associated with transient receptor potential (TRP) channels, particularly TRPV1, which contribute to the exaggerated sensory responses seen in SS. Furthermore, psychological factors like stress and anxiety, along with environmental stressors such as pollution and ultraviolet exposure, play significant roles in exacerbating symptoms. The diverse and individualized responses to stimuli make it difficult to establish standardized diagnostic criteria for SS, necessitating a combination of subjective diagnostic tools (e.g., the Sensitive Scale-10) and objective assessments (e.g., transepidermal water loss and lactic acid sting test) to accurately identify and assess SS. This paper provides a comprehensive review of SS, covering its definition, prevalence, pathogenesis, diagnostic challenges, and management strategies, and highlights the importance of personalized care in effectively managing SS and improving patient quality of life.

      Keywords: Skin diseases; Skin irritancy tests; Skin physiological phenomena; Pruritus; Pathophysiology; Sensitive Scale-10; Sensitive skin

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Measuring Anti-aging Effects in Drosophila

Measuring Anti-aging Effects in Drosophila

伤口世界,
2025-09-24 00:00
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Anti‑aging interventions in geriatric mice: insights  into the timing of treatment,  benefits, and limitations

Anti‑aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations

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2025-09-23 00:00
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Unveiling New Horizons: Advancing Technologies in Cosmeceuticals for Anti-Aging Solutions

Unveiling New Horizons: Advancing Technologies in Cosmeceuticals for Anti-Aging Solutions

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CASIN exerts anti-aging effects through RPL4 on the skin of  naturally aging mice

CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice

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2025-09-19 00:00
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  • 寻常痤疮临床严重度分级及疗效评价 中国专家共识(2025版) 2026-06-09 00:00

    中国医师协会皮肤科医师分会痤疮学组 中国研究型医院学会皮肤科学专业委员会 中国中西医结合学会皮肤性病专业委员会痤疮学组 通信作者:鞠强,Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。;顾恒,Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。;郑志忠, Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

    【摘要】 寻常痤疮(简称痤疮)是皮肤科常见的损容性皮肤病,临床表现多样。痤疮存在多种临 床严重度分级方法,但如何客观地评价疾病严重程度并用于指导痤疮治疗方案的选择,以及如何科 学评价各种治疗方式在痤疮治疗中的疗效目前仍缺乏统一标准,也是临床医生极为关注的问题。为此,中国医师协会皮肤科医师分会痤疮学组、中国研究型医院学会皮肤科学专业委员会、中国中西医结合学会皮肤性病专业委员会痤疮学组组织我国痤疮诊疗领域部分专家,在广泛讨论的基础上制订《寻常痤疮临床严重度分级及疗效评价中国专家共识》,供皮肤科医师临床应用参考。【关键词】 寻常痤疮;治疗;严重度分级;疗效评价;专家共识 DOI:10.35541/cjd.20250034

    Chinese expert consensus on clinical severity grading and therapeutic evaluation of acne vulgaris (2025 edition)

    Acne Study Group of China Dermatologist Association; Dermatology Professional Committee of Chinese Research Hospital Association; Acne Study Group of Dermatology and Venereology Professional Committee of Chinese Association of Integrative Medicine

    Corresponding authors: Ju Qiang, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Gu Heng, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Zheng Zhizhong, Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

    【Abstract】 Acne vulgaris (abbreviated as acne) is a common aesthetic ⁃ impairing dermatological disease that markedly affects appearance, and is characterized by diverse clinical manifestations. At present, there are various grading systems for acne severity, while there is still a lack of unified standards for objectively assessing disease severity to guide treatment selection and scientifically evaluating the efficacy of acne therapies, which are also highly concerned issues for clinicians. To address this, the Acne Study Group of China Dermatologist Association, the Dermatology Professional Committee of Chinese Research Hospital Association, and the Acne Study Group of Dermatology and Venereology Professional Committee of Chinese Association of Integrative Medicine organized a group of experts in the field of acne diagnosis and treatment in China to develop the "Chinese expert consensus on clinical severity grading and therapeutic evaluation of acne vulgaris" after extensive discussions, aiming to provide a reference for dermatologists in clinical practice.

    【Key words】 Acne vulgaris; Treatment; Clinical severity grading; Therapeutic evaluation; Expert consensus DOI: 10.35541/cjd.20250034

  • Comprehensive Approaches to Diagnosis and Treatment of Sensitive Skin 2026-06-08 00:00

    Hye One Kim 1,* , Ji Young Um 1,* , Han Bi Kim 1 , So Yeon Lee 1 , Hyun Choi 2 , Jihye Kim 3 , Eunbi Ko 3 , Bo Young Chung 1 , Chun Wook Park 1

    1 Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea

    2 Make-up Lab, R&D Center, Kolmar Korea, Seoul, Korea

    3 Clinical Research Lab, Amorepacific R&I Center, Yongin, Korea

    ABSTRACT

    Sensitive skin (SS) is increasingly recognized as a complex syndrome characterized by discom-fort and heightened sensitivity to otherwise harmless stimuli, such as environmental changes, physical contact, and cosmetic products. This condition poses challenges in both diagnosis and treatment due to its variable presentation and subjective nature. The pathophysiological features of SS include neurogenic inflammation and small fiber neuropathy, largely driven by the hyperactivation of sensory nerves. This hyperactivation is closely associated with transient receptor potential (TRP) channels, particularly TRPV1, which contribute to the exaggerated sensory responses seen in SS. Furthermore, psychological factors like stress and anxiety, along with environmental stressors such as pollution and ultraviolet exposure, play significant roles in exacerbating symptoms. The diverse and individualized responses to stimuli make it difficult to establish standardized diagnostic criteria for SS, necessitating a combination of subjective diagnostic tools (e.g., the Sensitive Scale-10) and objective assessments (e.g., transepidermal water loss and lactic acid sting test) to accurately identify and assess SS. This paper provides a comprehensive review of SS, covering its definition, prevalence, pathogenesis, diagnostic challenges, and management strategies, and highlights the importance of personalized care in effectively managing SS and improving patient quality of life.

    Keywords: Skin diseases; Skin irritancy tests; Skin physiological phenomena; Pruritus; Pathophysiology; Sensitive Scale-10; Sensitive skin

  • Cai’s herbal tea enhances mitochondrial autophagy of type 1 diabetic mellitus β cells through the AMPK/mTOR pathway and alleviates inflammatory response 2026-06-06 00:00

    Hongchun Li1 ·Yanfei Gao2 · Mengdi Li1 ·Yue Dong1 · Jie Chen3 · Bingyue Zhang3 · Kaiqiang Li4 ·Yuqun Cai3

    Received: 11 January 2024 / Accepted: 30 May 2024 / Published online: 2 July 2024©The Author(s) 2024

    Abstract

    Background This study investigates the therapeutic mechanisms of Cai’s Herbal Tea in Type 1 Diabetes Mellitus (T1DM) mice,focusing on its effects on mitochondrial change and autophagy via the AMP-activated protein kinase (AMPK)—mammalian target of rapamycin (mTOR) pathway.

    Methods The composition of Cai’s Herbal Tea was analyzed by Ultra-High Performance Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry (UHPLC-Q/TOF-MS). C57BL/6 mice and Min6 pancreatic beta cells were divided into control, diabetic mellitus (DM)/high glucose (HG), and treatment groups (low, medium, and high doses of Cai’s Tea, and Metformin). Key physiological parameters, pancreatic islet health, Min6 cell morphology, viability, and insulin (INS) secretion were assessed. Small Interfering RNA-AMPK (si-AMPK) was utilized to confirm the pathway involvement. Results Cai’s Herbal Tea improved body weight, pancreatic islet pathological injury, and INS secretion whereas reduced total triglycerides, fasting blood sugar, and Interferon gamma (INF-γ) in T1DM mice,particularly at higher doses. In Min6 cells, Cai’s Tea mitigated HG-induced damage and proinflammatory response, enhancing cell viability and INS secretion. Notably, it reduced swelling and improved cristae structure in treated groups of mitochondria and promoted autophagy via the AMPK-mTOR pathway, evidenced by increased LC3II/LC3I and P-AMPK/AMPK ratios, and decreased P-mTOR/ mTOR and P62 expressions in pancreatic islet β-cells.Furthermore,these effects were converted by si-AMPK interference. Conclusion Cai’s Herbal Tea exhibits significant therapeutic efficacy in T1DM mice by improving mitochondrial health and inducing autophagy through the AMPK-mTOR pathway in pancreatic islet β-cells. These findings highlight its potential as a therapeutic approach for T1DM management.

    Keywords Animal study · Cai’s herbal tea · Type 1 diabetes mellitus · AMPK-mTOR pathway · Autophagy

    Abbreviations

    T1DM Type 1 diabetes mellitus

    INS Insulin

    IL-1β Interleukin-1β

    MAP1LC3

    AMPK

    UPLC-Q/TOF-MS

    Microtubule-associated protein 1 light chain 3

    AMP-activated protein kinase Ultra performance liquid chromatography-quadrupole/time of flight-mass

    spectrometry

    IDA Information dependent acquisition

    TG Total triglycerides

    TC Total cholesterol

    ELISA Enzyme-linked immunosorbent assay

    INF-γ Interferon gamma

    IL-4 Interleukin 4

    HE Hematoxylin and eosin

    IHC Immunohistochemistry

    TEM Transmission electron microscopy

    DMEM Dulbecco’s modified eagle medium

    HG High-glucose

    si-NC SiRNA negative control

    si-AMPK SiRNA AMP-activated protein

    kinase

    MTT 3-(4,5-Dimethylthiazol-2-yl)-2,5-di-

    phenyltetrazolium bromide

    GSIS Glucose stimulated INS secretion

    BIS Basal INS secretion

    ISI INS secretion index

    NOD Non-obese diabetic

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