Hallmarks of aging: An expanding universe（2023）--2

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09 10月 2024

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Author : 伤口世界

Hallmarks of aging: An expanding universe（2023）--2

To be continued.

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Latest from 伤口世界

Investigation of the anti-skin aging effects of taurine through mendelian randomization analysis of its relationship with immune cells
Anti-Aging Effects of Flavonoids from Plant Extracts
Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression
Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review
Holistic investigation of the anti-wrinkle and repair efficacy of a facial cream enriched with C-xyloside

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Investigation of the anti-skin aging effects of taurine through mendelian randomization analysis of its relationship with immune cells 2025-05-12 00:00

Hongtao Liu, MD1 | Honglai Zheng, MD1 | Siyuan Zhou, MD2 | Quan Lin, MD3

1 Guangxi Health Science College, Nanning, China

2 The Second Affiliated Hospital of Guangxi Medical University, Nanning, China

3 The People's Hospital of Laibin, Laibin, China

Hongtao Liu and Honglai Zheng contributed equally to this work.

Correspondence

Quan Lin, The People's Hospital of Laibin, Laibin 546100, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

[Correction added on 26 August 2024, after first online publication:The spelling of the second author’s surname has been corrected in this version.]

Abstract

Background: Aging skin, exacerbated by external factors like UV radiation and pollutants, is a major cosmetic concern. Taurine, renowned for its antioxidant and anti-inflammatory properties, may combat skin aging. We performed mendelian randomization (MR) analysis to investigate the causal link between taurine and immune cells linked to skin aging.

Objectives: To investigate the association between taurine and immune cells using mendelian randomization, to thereby explore the mechanism through which taurine exerts anti-aging effects on the skin via immune modulation.

Methods: A MR approach was employed using taurine-level data from the Ieu Open GWAS Project and immunocyte traits from a large European cohort. MR-Egger regression, weighted median estimation, and inverse variance weighting all provided statistical insights into causality. Sensitivity analyses assessed the heterogeneity and pleiotropy among the genetic instruments used.

Results: MR analysis identified a causal relationship between taurine levels and 10 immunocyte phenotypes, with taurine found to be negatively and positively associated with three and seven phenotypes, respectively. Sensitivity analysis revealed no significant heterogeneity or pleiotropy, suggesting reliable MR findings.

Conclusion: This study provides insights into the immunological pathways by which taurine contributes to skin anti-aging effects, suggesting that increasing taurine levels could offer a novel strategy for anti-aging skincare.

KEYWORDS

anti-aging treatment, immune cells, Mendelian randomization, monocytes, taurine
Anti-Aging Effects of Flavonoids from Plant Extracts 2025-05-08 00:00

Bogdan Păcularu-Burada 1,2 , Alexandru-Ionut, Cîrîc 3,* and Mihaela Begea 3

1 ICA Research & Development S.R.L., 202 Splaiul Independent,ei, 060021 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Dan Voiculescu Foundation for the Development of Romania, 011885 Bucharest, Romania

3 Faculty of Biotechnical Systems Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independent,ei, 060042 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Citation: Păcularu-Burada, B.; Cîrîc, A.-I.; Begea, M. Anti-Aging Effects of Flavonoids from Plant Extracts. Foods

2024, 13, 2441. https://doi.org/ 10.3390/foods13152441

Academic Editor: Barry Parsons

Received: 4 July 2024

Revised: 25 July 2024

Accepted: 29 July 2024

Published: 2 August 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues’ and cells’ morphology and functionality and consequently being responsible for aging-related diseases. Taking into account the actual preoccupations of both consumers and researchers, healthy anti-aging alternatives are being intensively studied in order to address such concerns. Due to their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights the possibilities to use flavonoids extracted from various plants for their antiaging potential on the skin, brain, and heart. Moreover, their anticarcinogenic, anti-inflammatory, and anti-diabetic properties are summarized, along with the senescence-associated mechanisms. Both the nutraceutical and cosmeceutical fields are continuously developing and flavonoids originating from plants are promising candidates to obtain such products. Thus, the bioactive compounds’ extraction and their subsequent involvement in innovative product manufacturing must be carefully performed while being aware of the various intrinsic and extrinsic factors that may affect the phytochemicals’ structures, bioavailability, and health effects.

Keywords: flavonoids; senescence; diseases; anti-aging; nutraceuticals
Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression 2025-05-07 00:00

Seongsu Kang 1 , Jiwon Park 1 , Zhihong Cheng 2 , Sanghyun Ye 1 , Seung-Hyun Jun 1,* and Nae-Gyu Kang 1,*

1 LG Household and Health Care R&D Center, Seoul 07795, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.K.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (J.P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.Y.)

2 Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.-H.J.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (N.-G.K.); Tel.: +82-2-6980-1239 (S.-H.J.); +82-2-6980-1533 (N.-G.K.)

Citation: Kang, S.; Park, J.; Cheng, Z.; Ye, S.; Jun, S.-H.; Kang, N.-G. Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression. Cells 2024, 13, 1799.

https://doi.org/10.3390/ cells13211799

Academic Editor: Paweł Kordowitzki

Received: 8 October 2024

Revised: 28 October 2024

Accepted: 28 October 2024

Published: 30 October 2024

Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Nicotinamide adenine dinucleotide (NAD+ ) is indispensable for the regulation of biological metabolism. Previous studies have revealed its role in aging and degenerative diseases, while crucially showing that supplementation with NAD+ or its precursors could ameliorate or reverse the progression of aging. Despite extensive evidence for the role and action of NAD+ in aging, its pharmacological activity on the skin, or even its mechanism, has not been elucidated. In this study, we established a novel approach to effectively utilize NAD+ for skin anti-aging by enhancing the pharmacological efficacy of exogenous NAD+ using a phytochemical complex consisting of quercetin, and enoxolone through inhibition of CD38. Through the comprehensive in vitro experiments based on human fibroblasts, we observed that exogenous NAD+ could exert protective effects against both extrinsic aging induced by ultraviolet light exposure and intrinsic aging. Additionally, we found that its effects were significantly boosted by quercetin and enoxolone. In this in-depth study, we demonstrated that these beneficial effects are mediated by improved sirtuin activation, autophagy, and mitochondrial functionality. Our approach is expected to verify the applicability of the topical application of NAD+ and offer more effective solutions for the unmet needs of patients and consumers who demand more effective anti-aging effects.

Keywords: nicotinamide adenine dinucleotide (NAD+ ); quercetin; enoxolone; anti-aging; topical application; CD38

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Hallmarks of aging: An expanding universe（2023）--2

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