文献精选

高二男生肛周脓肿手术 33 天后死亡，给我们普外医生敲响警钟!

胡海涛负压引流与创面修复

这个事件，对患者家属是悲剧，对医生更是悲剧！

为啥肛周脓肿这个常见疾病，大家都认为的小病，发展到急危重症，直至最后死亡？

个人经验总结：外伤后难愈合性小腿伤口处理策略

原创：胡大夫负压引流与创面修复

老烂腿，首先想到糖尿病性溃疡、静脉曲张溃疡、动脉缺血性伤口。

临床，外伤性小腿伤口进入难愈合状态，也很常见！

WHY？

先看几个案例：

案例1：男性患者，环卫工人，小腿外伤后2月伤口不愈合：

糖尿病足的肌腱外露，切除or保留？

原创：胡海涛负压引流与创面修复

3年来，第一例糖足截肢的经验分享

原创：胡海涛负压引流与创面修复

2016年至今，保足成功过百个，成功率大于95%，近期第一例糖尿病足患者，进入截肢流程，是医患双方达成的积极治疗方案，诊治经过如下：

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K2 Content

Motor and vestibular signals in the visual cortex permit the separation of self versus externally generated visual motion 2025-07-04 00:00

Mateo Ve´ lez-Fort,1,3 Lee Cossell,1,3 Laura Porta,1 Claudia Clopath,1,2 and Troy W. Margrie1,4,*

1 Sainsbury Wellcome Centre, University College London, London, UK

2 Bioengineering Department, Imperial College London, London, UK

3 These authors contributed equally

4 Lead contact

*Correspondence: t.margrie@ucl.ac.uk

https://doi.org/10.1016/j.cell.2025.01.032

SUMMARY

Knowing whether we are moving or something in the world is moving around us is possibly the most critical sensory discrimination we need to perform. How the brain and, in particular, the visual system solves this motion-source separation problem is not known. Here, we find that motor, vestibular, and visual motion signals are used by the mouse primary visual cortex (VISp) to differentially represent the same visual flow information according to whether the head is stationary or experiencing passive versus active translation. During locomotion, we find that running suppresses running-congruent translation input and that translation signals dominate VISp activity when running and translation speed become incongruent. This cross-modal interaction between the motor and vestibular systems was found throughout the cortex, indicating that running and translation signals provide a brain-wide egocentric reference frame for computing the internally generated and actual speed of self when moving through and sensing the external world.
Mapping the landscape of social behavior 2025-07-03 00:00

Ugne Klibaite,1,4,* Tianqing Li,2,4 Diego Aldarondo,1,3 Jumana F. Akoad,1 Bence P. O¨ lveczky,1,* and Timothy W. Dunn2,5,*

1 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA

2 Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA

3 Present address: Fauna Robotics, New York, NY 10003, USA

4 These authors contributed equally

5 Lead contact

*Correspondence: klibaite@fas.harvard.edu (U.K.), olveczky@fas.harvard.edu (B.P.O¨ .), timothy.dunn@duke.edu (T.W.D.)

https://doi.org/10.1016/j.cell.2025.01.044

SUMMARY

Social interaction is integral to animal behavior. However, lacking tools to describe it in quantitative and rigorous ways has limited our understanding of its structure, underlying principles, and the neuropsychiatric disorders, like autism, that perturb it. Here, we present a technique for high-resolution 3D tracking of postural dynamics and social touch in freely interacting animals, solving the challenging subject occlusion and partassignment problems using 3D geometric reasoning, graph neural networks, and semi-supervised learning. We collected over 110 million 3D pose samples in interacting rats and mice, including seven monogenic autism rat lines. Using a multi-scale embedding approach, we identified a rich landscape of stereotyped actions, interactions, synchrony, and body contacts. This high-resolution phenotyping revealed a spectrum of changes in autism models and in response to amphetamine not resolved by conventional measurements. Our framework and large library of interactions will facilitate studies of social behaviors and their neurobiological underpinnings.
Large language models deconstruct the clinical intuition behind diagnosing autism 2025-06-26 00:00

Jack Stanley,1,2,6 Emmett Rabot,3,4,6 Siva Reddy,1 Eugene Belilovsky,1,5 Laurent Mottron,3,4,7 and Danilo Bzdok1,2,7,8,*

1 Mila - Que´ bec Artificial Intelligence Institute, Montre´ al, QC H2S3H1, Canada

2 The Neuro - Montre´ al Neurological Institute (MNI), McConnell Brain Imaging Centre, Department of Biomedical Engineering, Faculty of Medicine, School of Computer Science, McGill University, Montre´ al, QC H3A2B4, Canada

3 Research Center, Centre Inte´ gre´ Universitaire de Sante´ et de Services Sociaux du Nord-de-lIle-de-Montre´ al (CIUSSS-NIM), Montre´ al, QC H4K1B3, Canada

4 Universite´ de Montre´ al, Montre´ al, QC H3C3J7, Canada

5 Department of Computer Science and Software Engineering, Concordia University, Montreal, QC H3G 1M8, Canada

6 These authors contributed equally

7 These authors contributed equally

8 Lead contact

*Correspondence: danilo.bzdok@mcgill.ca

https://doi.org/10.1016/j.cell.2025.02.025

SUMMARY

Efforts to use genome-wide assays or brain scans to diagnose autism have seen diminishing returns. Yet the clinical intuition of healthcare professionals, based on longstanding first-hand experience, remains the gold standard for diagnosis of autism. We leveraged deep learning to deconstruct and interrogate the logic of expert clinician intuition from clinical reports to inform our understanding of autism. After pre-training on hundreds of millions of general sentences, we finessed large language models (LLMs) on >4,000 free-form health records from healthcare professionals to distinguish confirmed versus suspected autism cases. By introducing an explainability strategy, our extended language model architecture could pin down the most salient single sentences in what drives clinical thinking toward correct diagnoses. Our framework flagged the most autism-critical DSM-5 criteria to be stereotyped repetitive behaviors, special interests, and perception-based behaviors, which challenges today,s focus on deficits in social interplay, suggesting necessary revision of long-trusted diagnostic criteria in gold-standard instruments.

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

高二男生肛周脓肿手术 33 天后死亡，给我们普外医生敲响警钟!

个人经验总结：外伤后难愈合性小腿伤口处理策略

糖尿病足的肌腱外露，切除or保留？

3年来，第一例糖足截肢的经验分享

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

文献精选

高二男生肛周脓肿手术 33 天后死亡，给我们普外医生敲响警钟!

个人经验总结：外伤后难愈合性小腿伤口处理策略

糖尿病足的肌腱外露，切除or保留？

3年来，第一例糖足截肢的经验分享

消息订阅

学术会议

伤口世界提示