Wang Shuaishuai 1† , Zhu Tongtong1† , Wang Dapeng2 ,
Zhang Mingran1 , Wang Xukai 1 , Yu Yue1 , Dong Hengliang1 ,
Wu Guangzhi 1 * and Zhang Minglei 1 *
1 Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, China,
2 Department of Orthopedics, Siping Central Hospital, Siping, China
EDITED BY
Xiaoyuan Li,
Northeast Normal University, China
REVIEWED BY
Fuzeng Ren,
Southern University of Science and
Technology, China
Gong Cheng,
Harvard University, United States
Ruogu Qi,
Nanjing University of Chinese Medicine,
China
*CORRESPONDENCE
Wu Guangzhi,
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Zhang Minglei,
†
These authors have contributed equally to this work
SPECIALTY SECTION
This article was submitted to Biomaterials, a section of the journal
Frontiers in Bioengineering and Biotechnology
RECEIVED 27 October 2022
ACCEPTED 18 January 2023
PUBLISHED 30 January 2023
CITATION
Shuaishuai W, Tongtong Z, Dapeng W, Mingran Z, Xukai W, Yue Y, Hengliang D, Guangzhi W and Minglei Z (2023), Implantable biomedical materials for treatment of bone infection.
Front. Bioeng. Biotechnol. 11:1081446.
doi: 10.3389/fbioe.2023.1081446
COPYRIGHT
© 2023 Shuaishuai, Tongtong, Dapeng, Mingran, Xukai, Yue, Hengliang, Guangzhi and Minglei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The treatment of bone infections has always been difficult. The emergence of drugresistant bacteria has led to a steady decline in the effectiveness of antibiotics. It is also especially important to fight bacterial infections while repairing bone deffects and cleaning up dead bacteria to prevent biofilm formation. The development of biomedical materials has provided us with a research direction to address this issue.
We aimed to review the current literature, and have summarized multifunctional antimicrobial materials that have long-lasting antimicrobial capabilities that promote angiogenesis, bone production, or “killing and releasing.” This review provides a comprehensive summary of the use of biomedical materials in the treatment of bone infections and a reference thereof, as well as encouragement to perform further research in this field.
KEYWORDS
biological materials, bone infection, multifunctional material, implantable material, treatment of bone infection, progress of infection treatment, multifunctionalization of materials
This article is excerpted from the 《 Frontiers in Endocrinology》 by Wound World
原创： 十六点五 中山二院糖尿病足中心
进一步的清创就到了骨骼，对于骨髓炎最彻底的治疗方法就是去除被细菌侵袭的骨，正常的骨骼一般是浅黄色，如果发白或者变黑，往往就提示这段骨头可能活性比较差，另外，还有一种是面积比较大的骨暴露，一般的肉芽组织很难爬上去，因此，对于坏死的骨头及较大面积的骨暴露，一般需要清除。
皮下组织中的脂肪组织在足部分布广泛，而皮下脂肪中血管分布非常少，在相对或绝对缺血的糖尿病足中，脂肪组织边缘的是否出血不是其是否存活的可靠指标。
这是一个我们在《糖尿病足切开设计（1）》中提到过，这次从不同角度谈谈足趾的保全。
大趾是足部最重要的结构，如果被切除，对足部的功能会有比较大的影响，因此，应该尽可能的保存。
感染的足趾是比较常见的一种糖尿病足表现形式，能否保全足趾是一个比较有技巧的工作，现举例说明
原创： 胡海涛 负压引流与创面修复
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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