伤口世界

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星期五, 06 9月 2019

【分享】国际共识文件--对伤口渗出物的有效评价及处理

赫曼关爱健康中诺医疗

渗出物管理是伤口愈合过程管控中非常重要的一个环节，它可能贯穿整个伤口治疗的过程。国际伤口愈合联合会（WUWHS， World Union of Wound Healing Societies）在2007年曾经发布过一份关于渗出物管理的共识文件，时隔十二年，因为各种新的临床护理技术及方法的出现，WUWHS认识到临床需要更多、更新的指导意见，因此组织专家组对旧版本的共识文件进行了更新，并于2019年年初发布了新版文件。华阳医疗临床小组对此份文件进行了编译，因篇幅较长，所以内容将分几期进行转发推送，供各位老师参考，并对其中不足之处做出指正，感谢。

星期五, 06 9月 2019

不良情绪对疤痕的影响

中诺医疗

疤痕确实给广大疤友带来了无穷的痛苦，但是看到许多疤痕并不重的，甚至都算不上疤痕的人，大喊压力如何大，如何影响疤痕修复，去疤痕的方法不管用什么的。请你不要大喊，这不叫压力。相比人家脸部的疤痕，相比大面积的疤痕这根本不算什么，相对而言，别人那些大面积疤痕修复更加困难。

星期五, 06 9月 2019

糖尿病人泡脚有风险

中诺医疗

文章转自公众号兰世亭作者 Dr.Panda

近几天气温陡降，老朱在家泡了一次脚，就十分钟左右。然而，他的脚还是烫伤了，伤口引发高烧、感染，甚至导致休克、昏迷。所幸经过及时抢救，老朱的命救回来了，但双脚却逃不掉截肢的厄运。

星期五, 06 9月 2019

最常见皮肤病及用药大全，值得收藏！

中国医学博士联络中诺医疗

来源：药圈

这些常见皮肤病用药，临床必知！

星期五, 06 9月 2019

三位院士警告：99%的血栓无征兆，记住一个字就能让你一生无栓！

都市资讯报中诺医疗

血栓就像是游走于血管内的幽灵，一旦堵塞血管，会使血液的运输系统瘫痪，其结果是致命的。而且，血栓可发生在任何年龄、任何时间，严重威胁着生命健康。

星期五, 06 9月 2019

送大家一份高发癌症预防手册

为自己和家人健康，请收藏！

K2 Content

Procyanidin A1 from Peanut Skin Exerts Anti-Aging Effects and Attenuates Senescence via Antioxidative Stress and Autophagy Induction 2025-04-27 00:00

Yajing Li , Lan Xiang and Jianhua Qi *

College of Pharmaceutical Sciences, Zhejiang University, Yu Hang Tang Road 866, Hangzhou 310058, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.L.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.X.)

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Academic Editors: Marina Garcia-Macia and Álvaro F. Fernández

Received: 18 February 2025

Revised: 5 March 2025

Accepted: 5 March 2025

Published: 7 March 2025

Citation: Li, Y.; Xiang, L.; Qi, J. Procyanidin A1 from Peanut Skin Exerts Anti-Aging Effects and Attenuates Senescence via Antioxidative Stress and Autophagy Induction. Antioxidants 2025, 14, 322.

https://doi.org/10.3390/ antiox14030322

Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

(https://creativecommons.org/ licenses/by/4.0/)

Abstract: The aging population is steadily increasing, with aging and age-related diseases serving as major risk factors for morbidity, mortality, and economic burden. Peanuts, known as the “longevity nut” in China, have been shown to offer various health benefits, with peanut skin extract (PSE) emerging as a key compound of interest. This study investigates the bioactive compound in PSE with anti-aging potential and explores its underlying mechanisms of action. Procyanidin A1 (PC A1) was isolated from PSE, guided by the K6001 yeast replicative lifespan model. PC A1 prolonged the replicative lifespan of yeast and the yeast-like chronological lifespan of PC12 cells. To further confirm its anti-aging effect, cellular senescence, a hallmark of aging, was assessed. In senescent cells induced by etoposide (Etop), PC A1 alleviated senescence by reducing ROS levels, decreasing the percentage of senescent cells, and restoring proliferative capacity. Transcriptomics analysis revealed that PC A1 induced apoptosis, reduced senescence-associated secretory phenotype (SASP) factors, and modulated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. The antioxidative capacity of PC A1 was also evaluated, showing enhanced resistance to oxidative stress in PC12 cells by reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels and increasing superoxide dismutase (SOD) activity. Moreover, PC A1 induced autophagy, as evidenced by an increase in fluorescence-labeled autophagic compartments and confirmation via Western blot analysis of autophagy-related proteins. In addition, the treatment of an autophagy inhibitor abolished the antioxidative stress and senescence-alleviating effects of PC A1. These findings reveal that PC A1 extended lifespans and alleviated cellular senescence by enhancing oxidative stress resistance and inducing autophagy, positioning it as a promising candidate for further exploration as a geroprotective agent.

Keywords: aging; peanut skin; procyanidin A1; cell senescence; antioxidative stress; autophagy; PI3K/Akt signaling pathway
Discovering Skin Anti-Aging Potentials of the Most Abundant Flavone Phytochemical Compound Reported in Siam Violet Pearl, a Medicinal Plant from Thailand by In Silico and In Vitro Assessments 2025-04-25 00:00

Chaiyawat Aonsri 1,2 , Sompop Kuljarusnont 3

and Duangjai Tungmunnithum 4,5,*

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Unit of Compounds Library for Drug Discovery, Mahidol University, Bangkok 10400, Thailand

3 Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

4 Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand

5 Le Studium Institute for Advanced Studies, 1 Rue Dupanloup, 45000 Orléans, France

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel./Fax: +66-26448696

Academic Editors: Lina Raudone,˙ Mindaugas Liaudanskas and Sonata Trumbeckaite

Received: 8 January 2025

Revised: 20 February 2025

Accepted: 24 February 2025

Published: 26 February 2025

Citation: Aonsri, C.; Kuljarusnont, S.; Tungmunnithum, D. Discovering Skin Anti-Aging Potentials of the Most Abundant Flavone Phytochemical Compound Reported in Siam Violet Pearl, a Medicinal Plant from Thailand by In Silico and In Vitro Assessments. Antioxidants 2025, 14, 272. https://doi.org/10.3390/ antiox14030272

Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).

Abstract: Currently, nutraceuticals and functional food/cosmeceutical sectors are seeking natural molecules to develop various types of phytopharmaceutical products. Flavonoids have been reported in antioxidant and many medical/pharmacological activities. Monochoria angustifolia or Siam violet pearl medicinal plant is the newest species of the genus Monochoria C. Presl, which have long been consumed as food and herbal medicines. Though previous work showed that apigenin-7-O-glucoside is the most abundant antioxidant phytochemical found in this medicinal plant, the report on anti-aging activity is still lacking and needs to be filled in. The objective of this work is to explore anti-aging capacities of the most abundant antioxidant phytochemical reported in this plant using both in silico and in vitro assessments. In addition, pharmacokinetic properties were predicted. Interestingly, the results from both in silico and in vitro analysis showed a similar trend that apigenin-7- O-glucoside is a potential anti-aging agent against three enzymes. The pharmacokinetic properties, such as adsorption, distribution, metabolism, excretion and toxicity (ADMET), of this compound are also provided in this work. The current study is also the first report on anti-aging properties of this Thai medicinal plant. However, the safety and efficacy of future developed products from this compound and clinical study should be determined in the future.

Keywords: flavone; Monochoria angustifolia; flavonoids; medicinal plants; anti-aging; molecular modeling; pharmacological activity; medical benefits
CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice 2025-04-24 00:00

Yijia Zhang1 | Xueer Wang1 | Jianyuan Huang1 | Xinyue Zhang1 | Lingwei Bu1 |

Yarui Zhang1 | Fengting Liang1 | Shenhua Wu1 | Min Zhang1 | Lu Zhang2 |

Lin Zhang1

1 GDMPA Key Laboratory of key Technologies for Cosmetics Safety and Efficacy Evaluation, NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China

2 Guangdong Provincial Key Laboratory of Proteomics, Department of Pathophysiology, Key Laboratory of Mental Health of the Ministry of Education, School of Basic Medical Sciences, Center for Orthopaedic Surgery of the Third Affiliated Hospital, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, China

Correspondence

Lu Zhang, Guangdong Provincial Key Laboratory of Proteomics, Department of Pathophysiology, Key Laboratory of Mental Health of the Ministry of Education, School of Basic Medical Sciences, Center for Orthopaedic Surgery of the Third Affiliated Hospital, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 Lin Zhang, GDMPA Key Laboratory of key Technologies for Cosmetics Safety and Efficacy Evaluation, NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Funding information

National Natural Science Foundation of China, Grant/Award Number: 82073417, 81872514 and 81971297; GDMPA Key Laboratory Project of Scientific and Technological Innovation, Grant/Award

Number: 2023ZDZ12; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2022A1515010768, 2023A1515012480 and 2024A121301233

Abstract

Skin aging has been associated with the onset of various skin issues, and recent studies have identified an increase in Cdc42 activity in naturally aging mice. While previous literature has suggested that CASIN, a specific inhibitor of Cdc42 activity, may possess anti-aging properties, its specific effects on the epidermis and dermis, as well as the underlying mechanisms in naturally aging mice, remain unclear. Our study revealed that CASIN demonstrated the ability to increase epidermal and dermal thickness, enhance dermal-epidermal junction, and stimulate collagen and elastic fiber synthesis in 9-, 15-, and 24-month-old C57BL/6 mice in vivo. Moreover, CASIN was found to enhance the proliferation, differentiation, and colony formation and restore the cytoskeletal morphology of primary keratinocytes in naturally aging skin in vitro. Furthermore, the anti-aging properties of CASIN on primary fibroblasts in aging mice were mediated by the ribosomal protein RPL4 using proteomic sequencing, influencing collagen synthesis and cytoskeletal morphology both in vitro and in vivo. Meanwhile, both subcutaneous injection and topical application exhibited anti-aging effects for a duration of 21 days. Additionally, CASIN exhibited anti-inflammatory properties, while reduced expression of RPL4 was associated with increased inflammation in the skin of naturally aging mice. Taken together, our results unveil a novel function of RPL4 in skin aging, providing a foundational basis for future investigations into ribosomal proteins. And CASIN shows promise as a potential anti-aging agent for naturally aging mouse skin, suggesting potential applications in the field.

KEYWORDS

CASIN, Cdc42, fibroblast, keratinocyte, ribosome, skin aging

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

【分享】国际共识文件--对伤口渗出物的有效评价及处理

不良情绪对疤痕的影响

糖尿病人泡脚有风险

最常见皮肤病及用药大全，值得收藏！

三位院士警告：99%的血栓无征兆，记住一个字就能让你一生无栓！

送大家一份高发癌症预防手册

学术会议

伤口世界提示

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

伤口世界

【分享】国际共识文件--对伤口渗出物的有效评价及处理

不良情绪对疤痕的影响

糖尿病人泡脚有风险

最常见皮肤病及用药大全，值得收藏！

三位院士警告：99%的血栓无征兆，记住一个字就能让你一生无栓！

送大家一份高发癌症预防手册

消息订阅

学术会议

伤口世界提示