Cellular senescence and wound healing in aged and diabetic skin

Arisa Kita1,2 , Sena Yamamoto3 , Yuki Saito1 * and Takako S. Chikenji 3 *

1 Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan, 2 Department of Plastic and Reconstructive Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan,

3 Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan

Cellular senescence is a biological mechanism that prevents abnormal cell proliferation during tissue repair, and it is often accompanied by the secretion of various factors, such as cytokines and chemokines, known as the senescenceassociated secretory phenotype (SASP). SASP-mediated cell-to-cell communication promotes tissue repair, regeneration, and development. However, senescent cells can accumulate abnormally at injury sites, leading to excessive inflammation, tissue dysfunction, and intractable wounds. The effects of cellular senescence on skin wound healing can be both beneficial and detrimental, depending on the condition. Here, we reviewed the functional differences in cellular senescence that emerge during wound healing, chronic inflammation, and skin aging. We also review the latest mechanisms of wound healing in the epidermis, dermis, and subcutaneous fat, with a focus on cellular senescence, chronic inflammation, and tissue regeneration. Finally, we discuss the potential clinical applications of promoting and inhibiting cellular senescence to maximize benefits and minimize detrimental effects.

KEYWORDS

cellular senescence, senescence-associated secretory phenotypes (SASP), woundhealing, aged-skin, diabetic skin

EDITED BY

Chengliang Deng, Affiliated Hospital of Zunyi Medical University, China

REVIEWED BY

Eleni Mavrogonatou, National Centre of Scientific Research Demokritos, Greece Mariaceleste Aragona, University of Copenhagen, Denmark

*CORRESPONDENCE Takako S. Chikenji, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 Yuki Saito, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

RECEIVED 25 November 2023

ACCEPTED 05 February 2024

PUBLISHED 19 February 2024

CITATION

Kita A, Yamamoto S, Saito Y and Chikenji TS (2024), Cellular senescence and wound healing in aged and diabetic skin. Front. Physiol. 15:1344116.

doi: 10.3389/fphys.2024.1344116

COPYRIGHT

© 2024 Kita, Yamamoto, Saito and Chikenji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these  terms.

Macrocystis pyrifera ferment-containing creams for optimizing facial skin rejuvenation

Michael Gold MD FAAD¹ | Yoon-Soo Cindy Bae MD FAAD² | David J. Goldberg MD JD FAAD^3,4 | Sumayah Jamal MD PhD⁵ | Amy B. Lewis MD⁶ | Shari Marchbein MD FAAD⁷ | Adriana Ros DO⁸ | Uma Santhanam PhD⁹ | Lisa DiNatale^9,10 | Jaime Emmetsberger PhD^9,10

细胞衰老与衰老相关疾病研究进展

田潇雨 卢娜

中国药科大学，中国·江苏 南京 210000

摘 要

衰老(Senecence)是细胞功能逐渐退化的一种状态，在这种状态下细胞几乎丧失复制能力，并且细胞周期抑制基因p16INK4a 的表达升高。细胞衰老贯穿生物个体的整个生命过程，在各种生理以及病理过程中发挥重要的作用。一方面，衰老的细胞能够促进胚胎发育，伤口愈合和宿主免疫反应以及抑制肿瘤发生发展等。另一方面，随着年龄增长而在体内积累的衰老细胞也会对机体带来有害的影响。这些不能增殖的细胞产生衰老相关分泌表型(Senescence-Associated Secretory PhenotypeSASP)，促进衰老相关疾病(Aging-related Diseae)的发生发展，而清除衰老细胞能够减缓衰老相关疾病的症状。因此寻找能够特异性杀死衰老细胞的药物(Senolytics)成为了抗衰老领域的研究重点。

关键词
细胞衰老;衰老相关分泌表型;衰老相关疾病;抗衰老;Senolytics

Advances in Research on Senescence in Health and Diseases

Xiaoyu Tian Na Lu

China Pharmaceutical University, Nanjing, Jiangsu, 210000, China

AbstractSenescence is a state in which the cell's functional characteristics are gradually deteriorating, in which the cell is at a sustained lowevel ofreplication and is accompanied by an increase in the expression of the cell cycle inhibitor pl6lNK4a The production of senescent cells occurs throughout life and plays key roles in various physiological and pathological proceses. These noneproliferating celsoccupy key cellular niches and produce senescence-associated secretory phenotype (SASP) which contributes to aging-related diseasesprogress. Therefore, the search for Senolytics has become the focus ofresearch in the field of anti-aging.

Keywords
cellular senescence, SASP, aging-related disease, anti-senescence, senolytics

间充质干细胞抗衰老的理论研究进展

刘淼  叶俊儒
(成都医学院第一附属医院，成都610000)
【摘要】研究抗衰老是当今社会的热点课题。干细胞是具有自我更新能力和多向分化能力的细胞,间充质干细胞包含其中。研究常用的间充质干细胞有骨髓间充质干细胞和脂肪间充质干细胞,二者均在组织修复和抗衰老方面有广泛的应用,有很好的发展前景。本文综述了近年来脂肪间充质干细胞抗衰老作用的特点、机制及应用研究进展。

【关键词】干细胞;骨髓间充质干细胞;脂肪间充质干细胞;抗衰老;组织修复【中图分类号】R725【文献标识码】A【文章编号】1005-1457(2017)04-30-7

Advances in the Theoretical Research of Mesenchymal Stem Cells

Liu Miao Ye Junru

( The first affiliated hospital ofchengdu medical college ,chengdu 610000 , China)
Research on aging is a hot topic in today's society, Mesenchymal stem cells is a kind of stem cells, hasAbstraettheability to self-renewal and multi-directional differentiation potential, Research between commonly used there arebone marrow mesenchymal stem cells and adipose mesenchymal stem cells, mesenchymal stem cells between both intissue repair and anti-aning has a wide range of applications, In this paper,the characteristics,mechanism and applica-tion of the anti-aging effect of adipose mesenchymal stem cells in recent years are reviewd.

【Key words】Stem Cells; Bone Marrow mesenchymal stem cells; Adipose Mesenchymal stem cells; Ant- Aging; Tissue repair

眼周年轻化联合治疗方案的临床管理

章 晾

（武汉美莱医疗美容整形医院，湖北 武汉，430000）

【摘 要】 目的 探讨应用手术和非手术联合治疗方案恢复眼周年轻化的临床管理概念。方法 综合分析患者眼周衰老临床表现，选择上睑松弛矫正术、眼袋整形术等手术治疗方案联合肉毒素、玻尿酸、光电治疗等非手术治疗方案进行个性化的治疗。

结果 患者 22 例，术后回访 3-18 个月，眼周年轻化联合治疗方案越全面效果满意度越高。结论 应针对眼周衰老制定个性化联合治疗方案，达到眼周年轻化的目的。

【关键词】眼周年轻化；眼整形术；肉毒素；透明质酸；单极射频

DOI：

The clinical management of the combined treatment of peri-orbital rejuvenation ZHANG Liang (Mylike Cosmetic Hospital, Hubei Province, 430000, China)

[ABSTRACT] Objective To explore the concept of clinical management in the application of combined surgical and non-surgical treatment to restore the peri-orbital rejuvenation. Methods The clinical manifestations of peri-orbital aging were analyzed comprehensively, and surgical treatment (Blepharoplasty and Eyebag surgery ) combined with non-surgical treatment was selected. Non-surgical treatment includes: Botulinum toxin injection , Laser therapy (Radio frequency ; Picosecond) and Microneeding therapy. Results 22 patients were followed up for 3-18 months. The more comprehensive the treatment, the higher the satisfaction. Conclusion It is necessary to make a Personalized combination therapy for peri-orbital aging, so as to achieve the goal of peri-orbital

[KEY WORDS] peri-orbital rejuvenation; Blepharoplasty; botulinum toxin; hyaluronic acid; monopolar radiofrequency

抗衰老药物的研究进展

何晨1，刘晶晶1，陈楠1，段路娟1，王斓星1，王丽丽2+(1．河北农业大学生命科学学院，保定071000；2．河北农业大学中国枣研究中心，保定071000)

摘要：目的

总结近年来研究人员在抗衰老药物研究领域的发现，为后期研究提供参考。方法通过查阅近5年的相关文献，对抗衰老药物进行分类归纳。结果抗衰老药物大致可分为中药类(如当归、人参和蜂王浆等)、小分子类(如二甲双胍、白藜芦醇、原花青素和雷帕霉素)和多肽类(如大米多肽、大豆多肽和人工合成多肽)，通过构建不同的生物模型(如D半乳糖致衰老小鼠模型、p53基因敲除斑马鱼模型和秀丽隐杆线虫模型等)可证实其抗衰老作用。结论尽管抗衰老药物的作用效果得到了证实，但其分子作用机制有待进一步阐明。

关键词：抗衰老药物；中药类；小分子类；多肽类

DOI：10．3969／i．issn．1004—2407．2020．01．035

中图分类号：R977

文献标志码：A

文章编号：1004—2407(2020)01一0154一04