Merve Tomas1 , Deniz Günal-Köroğlu1 , Senem Kamiloglu2,3, Tugba Ozdal4 and Esra Capanoglu1,5*

Abstract

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin’s structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, and reducing levels of inflammatory markers (IL-6, IL-8, etc.) and matrix metalloproteinases (MMP-1, MMP- 2) linked to aging. Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. This review explores the multifaceted roles of phytochemicals in maintaining and improving skin health, highlighting their mechanisms of action and potential in skin anti-aging

Keywords Skin care, Anti-aging, Phytochemicals, Polyphenols, Carotenoids, Fatty acids, Saponins, Alkoloids

*Correspondence:

Esra Capanoglu

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1 Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Türkiye

2 Department of Food Engineering, Faculty of Agriculture, Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye

3 Science and Technology Application and Research Center (BITUAM), Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye

4 Department of Food Engineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, 34959 Tuzla, Istanbul, Türkiye

5 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China

Leah Cliatt , Joanna Petrides

1. Dermatology, Rowan-Virtua School of Osteopathic Medicine, Stratford, USA 2. Family Medicine, Rowan-Virtua School of Osteopathic Medicine, Stratford, USA

Corresponding author: Leah Cliatt, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Abstract

Introduction

The COVID-19 pandemic sparked an interest in skincare with the closure of spas and salons. Skincare, one of TikTok's most popular dermatology-related hashtags, received hundreds of millions of views. The American Academy of Dermatology (AAD) sharedfacial cleansing recommendations; however, how many people follow them is unclear. Studies have shown a good daily facial cleansing andmoisturizing routine can increase microbiome diversityand skin hydration. This can be beneficial in conditions like psoriasis, eczema, and acne.

Purpose

The aim of the study is to assess how well people follow the AAD recommendations and evaluate any differences in this behavior by gender.

Methods

A 19-question survey was designed and administered utilizing Qualtrics. The questions included demographic information, facial cleansing practices, and motivation for skincare routine. The survey was distributed via Rowan Email and on various social media platforms (GroupMe, Instagram, etc.) to target the general population. The data was analyzed using SPSS.

Results

One hundred twenty-four responses were collected from 91 female-identifying and 33 male-identifying participants. There were statistically significant differences between genders for the use of non-alcoholic gentle cleanser (p<0.001), use of moisturizer after washing the face (p<0.001), washing the face after sweating (p<0.001), and using warm water (p=0.026). No statistically significant difference was seen for face washing occurrence between genders (p=0.098). Statistically significant differences were seen between genders for motivation: hygiene (p<0.001), beauty/anti-aging (p<0.001), and health (p=0.004).

Conclusion

Individuals who identify as female may be more likely to adhere to AAD facial skincare recommendations. This could be a result of self-reported motivations such as hygiene, beauty, and health.

Categories: Dermatology

Keywords: beauty, dermatologic agents, dermatology, face cleansing, face washing, female, hygiene, skin

Review began 11/19/2024

Review ended 12/12/2024

Published 12/16/2024

© Copyright 2024

Cliatt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

DOI: 10.7759/cureus.75810

Fan Yang1 Xinyuan Zhang2 Hua Wang1 Miao Guo1 Jinlong Zhang1 Xuejiao Feng3 Jiayi Yu3 Jiahui Yang3 Jinjin Zhu4 Yiyu Wang3

1 Research & Development Center, Mageline Biology Tech Co., Ltd, Wuhan, Hubei, China

2 Shanghai Skinshield Clinical Testing and Technological Research Ltd., Shanghai, China

3 Department of Dermatology, Air Force Medical Center, PLA, Beijing, China

4 Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China

Correspondence

Jinjin Zhu, Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, 430022, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Yiyu Wang, Department of Dermatology, Air Force Medical Center, PLA, Beijing, China.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.

Abstract

Background: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area.

Aim: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7).

Methods: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks.

Results: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants’ assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8.

Conclusion: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.

KEYWORDS

anti-aging, collagen, elastin, extracellular matrix, eye cream, wrinkle

Priscilla Huang1 | Olivia Supan1 | Cecilia L. Pak2 | Rahul C. Mehta1 | Elizabeth T. Makino11 Allergan Aesthetics, an AbbVie Company, Irvine, California, USA | 2SGS Stephens Inc., Richardson, Texas, USA

Correspondence: Olivia Supan (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Rahul C. Mehta is a former employee of Allergan Aesthetics, an AbbVie Company.

Received: 24 June 2024 | Revised: 21 August 2024 | Accepted: 26 August 2024

Funding: Allergan Aesthetics, an AbbVie Company, funded this study and participated in the study design, research, analysis, data collection, interpretation of data, reviewing, and approval of the publication. All authors had access to relevant data and participated in the drafting, review, and approval of this publication. No honoraria or payments were made for authorship. Medical writing support was provided by Illyce Nuñez, PhD of Peloton Advantage, LLC, an OPEN Health company, and funded by Allergan Aesthetics, an AbbVie Company.

Keywords: acne vulgaris | erythema | post-inflammatory hyperpigmentation | salicylic acid

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is

properly cited.

© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.