Oliver Kuss1,2,3 · Michael Roden3,4,5 · Sabrina Schlesinger1,3 · Annika Hoyer6
Received: 27 May 2024 / Accepted: 23 November 2024 / Published online: 12 December 2024 © The Author(s) 2024
Abstract
Aims Two prerequisites must be met for the precision treatment approach to be beneficial for treated individuals. First, there must be treatment heterogeneity; second, in case of treatment heterogeneity, clinical predictors to identify people who would benefit from one treatment more than from others must be available. There is an established meta-regression approach to assess these two prerequisites that relies on measuring the variability of a clinical outcome after treatment in placebo-controlled randomised trials. We recently applied this approach to the treatment of type 2 diabetes for the clinical outcomes of glycaemic control and body weight and repeat it for the clinical outcome of all-cause mortality.
Methods We performed a meta-regression analysis using digitalized individual participant information on time to death from 10 large cardiovascular outcome trials (7563 deaths from 99,746 participants) on DPP-4 inhibitors, GLP-1 receptor agonists, and SGLT-2 inhibitors with respect to the variability of all-cause mortality and its potential predictors after treatment.
Results The adjusted difference in log(SD) values of time to death between the verum and placebo arms was −0.036 (95%- CI: −0.059; −0.013), showing larger variability of time to death in the placebo arms. No clinical predictors were found to explain treatment heterogeneity.
Conclusions This analysis suggests that the potential of the precision treatment approach in type 2 diabetes is low, at least with regard to improvement of all-cause mortality in population with high cardiovascular risk. This extends our previous findings for the clinical outcomes of glycaemic control and body weight.
Keywords Dipeptidyl peptidase-4 inhibitors · Glucagon-like peptide 1 · HbA1c · Meta-regression · Precision medicine · Sodium–glucose transporter 2 inhibitors · Type 2 diabetes mellitus
Annunziata Lapolla1 · Maria Grazia Dalfrà1 · Giuseppe Marelli2 · Mario Parrillo3 · Laura Sciacca4 · Maria Angela Sculli5 · Elena Succurro6 · Elisabetta Torlone7 · Ester Vitacolonna8
Received: 18 September 2024 / Accepted: 27 December 2024 / Published online: 22 January 2025 © Springer-Verlag Italia S.r.l., part of Springer Nature 2025
Proper nutrition is essential during pregnancy to ensure an adequate supply of nutrients to the foetus and adequate maternal weight gain. In pregnancy complicated by diabetes (both gestational and pre-gestational), diet in terms of both the intake and quality of carbohydrates is an essential factor in glycaemic control. Maternal BMI at conception defines the correct weight increase during gestation in order to reduce maternal-foetal complications related to hypo- or hyper-nutrition. The recommendations presented here, which are based on national and international guidelines and the most recently published data on nutrition in physiological pregnancy and pregnancy complicated by hyperglycaemia and/or obesity, are designed to help healthcare professionals prescribe suitable eating patterns to safeguard the health of the mother and the foetus.
原创：伤口治疗及造口护理中心
不管哪种肤质，哪怕是“天生丽质”的人，都会存在或多或少的小毛病，每种不同的肤质可能出现的问题也各有侧重，当皮肤出现问题时就应该警醒了，应该立即审视和调整你的计划，那么我们应该如何科学评估自己的皮肤？今天小编就告诉大家医生及伤口师是如何评估我们的皮肤的。
皮肤是作为人类健康与美丽的象征，当我们最初注意到一个人时，她健康的肌肤往往是形成美好的第一印象的重要因素。
健康与美丽是分不开的，尤其是对皮肤来说，这一点更加重要，如果没有了健康，便根本谈不上皮肤的美丽。
在日常的工作、学习、生活中，难免会有磕磕碰碰，时不时我们的身体就是因某些原因，造成不可避免的伤口出现。有时我们会发现，有些伤口会快速愈合甚至不留痕迹，而有些伤口经久不愈甚至情况愈演愈烈，造成不可挽回的后果，只有我们能够简单的初步认识伤口的各种情况，才能更好地对待我们所发生的一些伤口情况，使其快速愈合，让我们的身体恢复健康。
今天，小编就给大家讲解一下什么是伤口以及伤口的分类。
在日常生活中，当我们的机体受到伤害而造成伤口的时候，最希望伤口能够尽快愈合，恢复到未受伤时候的状态。通过观察不难发现，伤口几乎是一天一个样，那么机体是如何让伤口产生这些变化的呢？伤口有时如何进行修复的呢？
今天小编就告诉大家伤口的愈合过程，通过了解这个过程，我们能够更好地了解自己伤口所处在的周期，以及能够大概了解伤口是往好的方向发展还是往坏的方向恶化。话不多说，下面介绍今天的主题！
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
扫一扫了解详情:
任何关于疾病的建议都不能替代执业医师的面对面诊断。所有门诊时间仅供参考，最终以医院当日公布为准。
网友、医生言论仅代表其个人观点，不代表本站同意其说法，请谨慎参阅，本站不承担由此引起的法律责任。
