Patrick Bogdanowicz 1,4囚 , Paul Bensadoun 2,4, Maïté Noizet 1 , Benoît Béganton 1 , Armony Philippe 1 , SandrineAlvarez‑Georges 1 , Gautier Doat 3 , AmélieTourette 1 , Sandrine Bessou‑Touya 1 , Jean‑Marc Lemaitre 2囚 & Hélène Duplan 1
1 R&D Pierre Fabre Dermo-Cosmétique & Personal Care, Toulouse, France.
2 INSERM IRMB UMR1183, Hôpital Saint Eloi, Université de Montpellier, Montpellier, France.
3 Laboratoires Dermatologiques Avène, Lavaur, France. 4These authors contributed equally: Patrick Bogdanowicz and Paul Bensadoun.
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Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) that includes MMPs, CXCLs and S100A8/9. Reducing the SASP with senotherapeutics is a promising strategy to reduce skin aging. Here we evaluated the effect of a formula containing niacinamide and hyaluronic acid, which are known to limit senescence and skin aging. We conducted three different studies. (1) Ex vivo explants treated with the formula had more collagen and glycosaminoglycan. (2) In a clinical trial with forty-four women, two months of treatment improved fne lines, wrinkles, luminosity, smoothness, homogeneity, and plumpness. (3) In a third study on thirty women, we treated one arm for two months and took skin biopsies to study gene expression. 101 mRNAs and 13 miRNAs were differentially expressed. We observed a likely senomorphic efect, as there was a decrease in many SASP genes including MMP12 and CXCL9 and a significant downregulation of autocrine signaling genes: S100A8 and S100A9. These pharmaco-clinical results are the first to demonstrate the senomorphic properties of an effective anti-aging formula in skin.
Merve Tomas1 , Deniz Günal-Köroğlu1 , Senem Kamiloglu2,3, Tugba Ozdal4 and Esra Capanoglu1,5*
*Correspondence: Esra Capanoglu 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
1 Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, 34469 Maslak, Istanbul, Türkiye
2 Department of Food Engineering, Faculty of Agriculture, Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye
3 Science and Technology Application and Research Center (BITUAM), Bursa Uludag University, 16059 Gorukle, Bursa, Türkiye
4 Department of Food Engineering, Faculty of Engineering and Natural Sciences, Istanbul Okan University, 34959 Tuzla, Istanbul, Türkiye
5 School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Abstract
Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin’s structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, and elastase, which degrade skin structure, and reducing levels of inflammatory markers (IL-6, IL-8, etc.) and matrix metalloproteinases (MMP-1, MMP- 2) linked to aging. Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. This review explores the multifaceted roles of phytochemicals in maintaining and improving skin health, highlighting their mechanisms of action and potential in skin anti-aging
Keywords Skin care, Anti-aging, Phytochemicals, Polyphenols, Carotenoids, Fatty acids, Saponins, Alkoloids
原创:伤口治疗及造口护理中心
下肢静脉性溃疡,俗称“老烂腿”,是下肢静脉疾病的常见临床表现。下肢静脉性溃疡常常反复发作,溃疡久治不愈,严重影响患者的正常生活,因此一旦出现下肢静脉性溃疡的现象,患者应该及时到正规医院的血管外科就医,以查清病因,对症下药.
下肢静脉性溃疡,俗称“老烂腿”,是下肢静脉疾病的常见临床表现。下肢静脉性溃疡常常反复发作,溃疡久治不愈,严重影响患者的正常生活,因此一旦出现下肢静脉性溃疡的现象,患者应该及时到正规医院的血管外科就医,以查清病因,对症下药。
今天我们来了解一下下肢静脉的基本机构及特点。
糖尿病足是糖尿病后期最严重的并发症之一,据文献统计,糖尿病足的发病率在糖尿病住院病人中约占15%的比例,糖尿病鞋是针对糖尿病足的保护专门研发设计的新型健康鞋,其合适的选材与科学的做工,可有效保护糖尿病足的患者。
足部是糖尿病这个多系统疾病的一个复杂的靶器官。糖尿病患者因周围神经病变与外周血管疾病合并过高的机械压力,可引起足部软组织及骨关节系统的破坏与畸形形成,进而引发一系列足部问题,从轻度的神经症状到严重的溃疡、感染、血管疾病、Charcot关节病和神经病变性骨折。如果积极治疗不能充分解决下肢出现的症状和并发症,则会造成灾难性的后果。因此,在糖尿病患者中开展对足部问题的早期预防和治疗将有重要的意义。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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