Anti-aging and immunomodulatory role of caffeine in Drosophila larvae

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28 9月 2025

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Author : 伤口世界

Anti-aging and immunomodulatory role of caffeine in Drosophila larvae

This article is excerpted from the 《Small Science》 by Wound World

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1型糖尿病多重环境因素的研究进展* 2026-11-10 00:00

王爽¹,王涵学¹,孟晓彤¹,朱晓双¹,王亚蕊^1,2,陈蕴^1,2△ (1.新疆医科大学护理学院,乌鲁木齐 830000;2.新疆区域人群疾病与健康照护研究中心,乌鲁木齐 830000)

[摘要] 近年来,1型糖尿病发病率呈上升趋势,其发病原因极为复杂,发生机制尚未完全阐明。已有研究证实1型糖尿病的发生和演变是典型的多基因、多因素、多阶段和多途径的过程,是遗传和环境因素共同作用所致。目前认为环境因素与感染因素、饮食因素、早期暴露事件、肠道菌群、免疫因素、其他因素及遗传因素的交互作用有关。该文对近年来1型糖尿病多重环境因素的相关研究进行综述。

[关键词] 1型糖尿病;环境因素;多重;自身免疫;综述

[中图法分类号] R587.1

[文献标识码] A

[文章编号] 1671-8348(2025)05-1255-05

Advancesonmultipleenvironmentalfactorsaffectingtype1diabetes *

WANGShuang ¹,WANG Hanxue ¹,MENGXiaotong ¹,ZHU Xiaoshuang ¹,WANGYarui ^1,2,CHEN Yun ^1,2△ (1.NursingSchool,XinjiangMedicalUniversity,Urumqi,Xinjiang830000,China; 2.HealthCareResearchCenterforXinjiangRegionalPopulation,Urumqi,Xinjiang830000,China)

[Abstract]

In recent years, the incidence rate of type 1 diabetes is on the rise. The causes of the diseaseare extremely complex, and the pathogenesis has not yet been fully clarified. Different types of studies haveconfirmed that the occurrence and evolution of type 1 diabetes is a typical process of polygene, multifactor.multi-stage and multi-channel,which is considered to be caused by the combined effect of genetic and environmental factors, At present.it is believed that environmental factors are related to the interaction of infectionactors, diet factors,early exposure events,intestinal flora,immune factors,other factors and genetic factors.This article reviews the research on environmental factors of type 1 diabetes in recent years.

[Key words] type 1 diabetes;environmental factors; multiple;autoimmunity; review
Bactericidal and anti-inflammatory activity of defined hypochlorite solution 2026-11-09 00:00

Christopher David Chapman ^1,2☯*, Myles Hyla Edward Dakin ², Richard Aspinall^1☯

¹Centre for Intelligent Healthcare, Coventry University, United Kingdom, ²Hypo-stream Limited, Cambridge, United Kingdom

☯ These authors contributed equally to this work.

Abstract

Background

Hypochlorite is an antiseptic that has been used for over a century for industrial sterilisation and antisepsis. More recently, the topical application of hypochlorite to severe burn patients increased their rate of survival post infection with Gram-negative bacteria, of which antisepsis cannot be solely responsible.

Methodology

Broth microdilution experiments were performed to confirm anti-microbial activity. Cytokine exposure was performed by dialytic exposure of serum spiked with either interleukin-6 or interleukin-10, accounting for contextually appropriate organic load. Cytokine degradation was measured by immunoassay and by functional bioassay utilising HEK-Blue cells. Hypochlorite mediated cytotoxicity against dermal cells was assessed via direct exposure, followed by a 1-hour attenuation period. Resazurin was utilised to assay the impact of hypochlorite on cell viability.

Results

We have shown that this formulation of hypochlorite in isotonic saline has multiple mechanisms. The first is that 7 mmol/L hypochlorite is capable of eliminating both Gram-negative and Gram-positive bacteria, and that the same concentration differentially degrades the function of IL-6 and IL-10. IL-6 was seen to be 3 times more susceptible to loss of function than IL-10 after only 5 minutes of exposure (P<0.005). The asymmetrical effect on these cytokines was observed between 7 and 1.75 mmol/L, and across the entire time scale examined. This hypochlorite formulation has the capability to sterilize a wound, and by altering the cytokine profile reduce inflammation and scarring, and improve wound healing.

Conclusions

These findings, taken with the burn survival study, suggest that the increased survival rate after application of hypochlorite could be due to the combined effect of elimination of infective pathogens, and the differential degradation of interleukin-6 and interleukin-10 at the site of injury
Periprocedural Use of Hypochlorous Acid Mist for Improving Healing and Cosmesis of the Face After Laser 2026-11-07 00:00

Marianna Blyumin-Karasik¹ | Jessica Colon² | Sophie Gaer¹ | Isabella Vigil¹ | Sylvie Nguyen² | Jordan Rosen¹

¹Precision Skin & Body Institute, Davie, Florida, USA |²Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, Florida, USA

Correspondence: Marianna Blyumin-Karasik (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)

Received: 12 May 2025 | Revised: 7 August 2025 | Accepted: 12 August 2025

Funding: The authors received no specific funding for this work.

Keywords: aesthetic | cosmeceuticals | hypochlorous acid | integrated skincare | laser treatment | photoaging | resurfacing laser

ABSTRACT

Background: Laser resurfacing treatments have revolutionized dermatological procedures by improving skin texture, tone, and quality. Effective periprocedural care remains essential to reduce side effects, support healing, and optimize aesthetic outcomes. Hypochlorous acid (HOCl), a naturally occurring oxidant with anti-inflammatory and antimicrobial properties, has demonstrated efficacy in promoting wound healing and minimizing scarring.

Aim: To evaluate the use of stabilized HOCl mist in the periprocedural care of patients undergoing laser resurfacing.

Methods: Ten patients underwent treatment with UltraClear, CO2RE, and/or GentleMax Pro laser devices. Stabilized HOCl mist was applied before and after the procedure, with continued application twice daily for 1week posttreatment. Follow-up assessments at 1–3weeks and 1–3months post-procedure included clinical photography, tolerability evaluation, and aesthetic outcome assessment. Outcomes measured included Clinician Erythema Assessment (CEA), 4-point Edema Scale, Investigator Global Assessment of Pigmentation Scale (IPA), and Global Aesthetic Improvement Scale (GAIS). Statistical analysis was performed using the Friedman and Wilcoxon signed-rank tests.

Results: HOCl mist was associated with accelerated recovery, including a noticeable reduction in erythema and pigmentation. Statistically significant improvements were observed in CEA (p=0.007) and IPA (p=0.012) scores, indicating reduced clinical severity and pigment alteration. Edema and GAIS scores showed no statistically significant change.

Conclusion: Stabilized HOCl mist is well-tolerated and may significantly aid post-procedural recovery by minimizing side effects and reducing discomfort. Results support the potential role of stabilized HOCl mist as a beneficial adjunct in post-laser skincare, contributing to faster healing, reduced inflammation, and enhanced cosmetic results.

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Anti-aging and immunomodulatory role of caffeine in Drosophila larvae

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

Anti-aging and immunomodulatory role of caffeine in Drosophila larvae

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