Qianqian Wang1 Nihong Li2,3 Mingyu Wang2,3 Yuting Jin2,3 Rui Ye2,3 Le Du2,3 Fan Hu2,3
1 Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China
2 UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., Shanghai, China
3 DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai, China
Correspondence
Fan Hu,UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., 19F, No.8 Huaihai Rd (M), Lansheng Building, Huangpu District, Shanghai.
Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Abstract
Background: The assessment of skin aging through skin measurements faces limitations, making perceived age evaluation a more valuable and direct tool for assessing skin aging. Given that the aging process markedly affects the appearance of the eye contour, characterizing the eye region could be beneficial for perceived age assessment. This study aimed to analyze age-correlated changes in the eye contour within the Chinese Han female population and to develop, validate, and apply a multiple linear regression model for predicting perceived age.
Materials and methods: A naïve panel of 107 Chinese women assessed the perceived ages of 212 Chinese Han women. Instrumental analysis evaluated periorbital parameters, including palpebral fissure width (PFW), palpebral fissure height (PFH), acclivity of palpebral fissure (AX), angle of inner canthal (AEN), and angle of outer canthal (AEX). These parameters were used to construct a multiple linear regression model for predicting the perceived ages of Chinese Han women. A combined treatment using Fotona 4D and an anti-aging eye cream, formulated with plant extracts, peptides, and antioxidants, was conducted to verify the cream’s anti-aging efficacy and safety. This eye cream was then tested in a large-scale clinical trial involving 101 participants. The prediction model was employed in this trial to assess the perceived ages of the women after an 8-week application of the eye cream.
Results: All parameters were observed to decrease with age. An intergroup comparison indicated that eyelid aging in Chinese Han women accelerates beyond the age of 50. Consequently, a linear regression model was constructed and validated, with the perceived age being calculated as 183.159 - 1.078 * AEN - 4.487 * PFW + 6.061 * PFH - 1.003 * AX - 0.328 * AEX. The anti-aging efficacy and safety of the eye cream were confirmed through combined treatment with Fotona 4D, showing improvements in wrinkles, elasticity, and dark circles under the eyes. In a large-scale clinical evaluation using this eye cream, a perceived age prediction model was applied, suggesting that 8 weeks of use made participants appear 2.25 years younger.
Conclusion: Our study developed and validated a multiple linear regression model to predict the perceived age of Chinese Han women. This model was successfully utilized in a large-scale clinical evaluation of anti-aging eye cream, revealing that 8 weeks of usage made participants appear 2.25 years younger. This method effectively bridges the gap between clinical research and consumer perceptions, explores the complex factors influencing perceived age, and aims to improve anti-aging formulations.
KEYWORDS
anti-aging, Chinese Han women, perceived, periorbital, prediction model, skin
Maheshvari N. Patel , Nayan K. Patel , Apeksha M. Merja , Saurav Patnaik
1. Clinical Research, NovoBliss Research Private Limited, Ahmedabad, IND 2. Pharmacology, Swaminarayan University, Ahmedabad, IND 3. Dermatology, NovoBliss Research Private Limited, Ahmedabad, IND 4. Cosmetology, Anveya Living Private Limited, Gurgaon, IND
Corresponding author: Maheshvari N. Patel, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Review began 09/06/2024
Review ended 09/18/2024
Published 09/23/2024
© Copyright 2024
Patel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.7759/cureus.69968
Categories: Dermatology
Keywords: dark spots, facial cleanser and serum, porphyrins, iga scoring, niacinamide, acne
1, 2 1 3 4
Open Access Original Article
How to cite this article
Patel M N, Patel N K, Merja A M, et al. (September 23, 2024) Clinical Evaluation of the Efficacy, Safety, and In-Use Tolerability of a Diacnemide™-Containing Acne Kit (Facial Serum and Cleanser) Regimen for the Synergistic Management of Facial Acne in Adults. Cureus 16(9): e69968.
DOI 10.7759/cureus.69968
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