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Wang L, PhD, a Bassiri M, PhD, a Najafi R, PhD, a Najafi K, MD, b Yang J, BS, a Khosrovi B, PhD, a Hwong W, BS, a Barati E, BS, a Belisle B, PhD, a Celeri C, MSa , and Robson MC, MD c
aNovaBay Pharmaceuticals, Inc, Emeryville, CA; bEye Institute San Rafael, CA; and c Institute for Tissue Regeneration, Repair and Rehabilitation, Bay Pines, FL.
Objective: Hypochlorous acid (HOCl), a major inorganic bactericidal compound of innate immunity, is effective against a broad range of microorganisms. Owing to its chemical nature, HOCl has never been used as a pharmaceutical drug for treating infection. In this article, we describe the chemical production, stabilization, and biological activity of a pharmaceutically useful formulation of HOCl. Methods: Stabilized HOCl is in the form of a physiologically balanced solution in 0.9% saline at a pH range of 3.5 to 4.0. Chlorine species distribution in solution is a function of pH. In aqueous solution, HOCl is the predominant species at the pH range of 3 to 6. At pH values less than 3.5, the solution exists as a mixture of chlorine in aqueous phase, chlorine gas, trichloride (Cl− 3 ), and HOCl. At pH greater than 5.5, sodium hypochlorite (NaOCl) starts to form and becomes the predominant species in the alkaline pH. To maintain HOCl solution in a stable form, maximize its antimicrobial activities, and minimize undesirable side products, the pH must be maintained at 3.5 to 5. Results: Using this stabilized form of HOCl, the potent antimicrobial activities of HOCl are demonstrated against a wide range of microorganisms. The in vitro cytotoxicity profile in L929 cells and the in vivo safety profile of HOCl in various animal models are described. Conclusion: On the basis of the antimicrobial activity and the lack of animal toxicity, it is predicted that stabilized HOCl has potential pharmaceutical applications in the control of soft tissue infection.
伤口、造口、失禁护理俱乐部
对烧伤外科、整形外科及美容外科有较深的造谐，擅长大面积严重烧伤的救治，唇腭裂修复、软组织缺损的修复及各类美容整形和再造整形手术，每年完成大小各类手术360余例。
从事整形外科近30年，留美多年，熟练掌握面部美容、除皱、乳房整形、脂肪抽吸等各类美容整形外科手术及各种非手术美容(如肉毒毒素A注射除皱等)，对外生殖器整形与再造，两性畸形和易性症的手术治疗等有较深入研究。
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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