Seongsu Kang 1 , Jiwon Park 1 , Zhihong Cheng 2 , Sanghyun Ye 1 , Seung-Hyun Jun 1,* and Nae-Gyu Kang 1,*
1 LG Household and Health Care R&D Center, Seoul 07795, Republic of Korea; franck.kang@lghnh.com (S.K.); jwon1222@lghnh.com (J.P.); shye123@lghnh.com (S.Y.)
2 Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China; chengzhh@fudan.edu.cn
* Correspondence: junsh@lghnh.com (S.-H.J.); ngkang@lghnh.com (N.-G.K.); Tel.: +82-2-6980-1239 (S.-H.J.); +82-2-6980-1533 (N.-G.K.)
Citation: Kang, S.; Park, J.; Cheng, Z.; Ye, S.; Jun, S.-H.; Kang, N.-G. Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression. Cells 2024, 13, 1799.
https://doi.org/10.3390/ cells13211799
Academic Editor: Paweł Kordowitzki
Received: 8 October 2024
Revised: 28 October 2024
Accepted: 28 October 2024
Published: 30 October 2024
Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Abstract: Nicotinamide adenine dinucleotide (NAD+ ) is indispensable for the regulation of biological metabolism. Previous studies have revealed its role in aging and degenerative diseases, while crucially showing that supplementation with NAD+ or its precursors could ameliorate or reverse the progression of aging. Despite extensive evidence for the role and action of NAD+ in aging, its pharmacological activity on the skin, or even its mechanism, has not been elucidated. In this study, we established a novel approach to effectively utilize NAD+ for skin anti-aging by enhancing the pharmacological efficacy of exogenous NAD+ using a phytochemical complex consisting of quercetin, and enoxolone through inhibition of CD38. Through the comprehensive in vitro experiments based on human fibroblasts, we observed that exogenous NAD+ could exert protective effects against both extrinsic aging induced by ultraviolet light exposure and intrinsic aging. Additionally, we found that its effects were significantly boosted by quercetin and enoxolone. In this in-depth study, we demonstrated that these beneficial effects are mediated by improved sirtuin activation, autophagy, and mitochondrial functionality. Our approach is expected to verify the applicability of the topical application of NAD+ and offer more effective solutions for the unmet needs of patients and consumers who demand more effective anti-aging effects.
Keywords: nicotinamide adenine dinucleotide (NAD+ ); quercetin; enoxolone; anti-aging; topical application; CD38
Andrada Pintea 1 , Andrei Manea 1,* , Cezara Pintea 1 , Robert-Alexandru Vlad 2 , Magdalena Bîrsan 3 , Paula Antonoaea 2 , Emöke Margit Rédai 2 and Adriana Ciurba 2
1 Medicine and Pharmacy Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania
2 Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania; adriana.ciurba@umfst.ro (A.C.)
3 Department of Drug Industry and Pharmaceutical Biotechnology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
* Correspondence: andrei.manea@umfst.ro
Academic Editors: Maurice Am Van
Steensel and Jean-Luc Poyet
Received: 29 November 2024
Revised: 28 December 2024
Accepted: 8 January 2025
Published: 9 January 2025
Citation: Pintea, A.; Manea, A.; Pintea, C.; Vlad, R.-A.; Bîrsan, M.; Antonoaea, P.; Rédai, E.M.; Ciurba, A.
Peptides: Emerging Candidates for the Prevention and Treatment of Skin
Senescence: A Review. Biomolecules 2025, 15, 88. https://doi.org/ 10.3390/biom15010088
Copyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
Abstract: One class of cosmetic compounds that have raised interest of many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use of peptides in cosmetic products. Peptides are novel active ingredients that improve collagen synthesis, enhance skin cell proliferation, or decrease inflammation. Based on their mechanism of action, they can be classified into signal peptides, carrier peptides, neurotransmitter inhibitor peptides, and enzyme inhibitor peptides. This review focuses on the main types of peptides and their application in the cosmetic field, underlining their main limitations. One of the most significant drawbacks of cosmetic peptides is their poor permeability through membranes, which limits their delivery and effectiveness. As a result, this review follows the methods used for improving permeability through the stratum corneum. Increasing peptide bioavailability and stability for enhanced delivery to the desired site of action and visible effects have become central points for the latest research due to their promising features. For this purpose, several methods have been identified and described. Physical techniques include thermal ablation (radiofrequency and laser), electrical methods (electroporation, iontophoresis), mechanical approach (microneedles), and ultrasounds. As an alternative, innovative formulations have been developed in nanosystems such as liposomes, niosomes, ethosomes, nanoemulsions, and other nanomaterials to reduce skin irritation and improve product effectiveness. The purpose of this review is to provide the latest information regarding these noteworthy molecules and the reasoning behind their use in cosmetic formulations.
Keywords: cosmetic peptides; anti-aging products; permeability; nano-systems
原创: 胡海涛 负压引流与创面修复
近日处理多位慢性伤口患者,他们的病程时间都大于五月,最长患者达六年,并且有相同的经历——换药、换药、换药,吃抗生素、抗生素、抗生素!
刘晗 负压引流与创面修复
是不是 瘘了?
原创: 十六点五 中山二院糖尿病足中心
男性,24岁,3年前外院诊断“下丘脑生殖细胞瘤”,进行γ刀治疗后,长期应用“氢化可的松”早晚各2片维持,半年前不慎损伤左小腿下部外侧皮肤,之后长期不愈合,收入院。
含银的敷料是目前治疗糖尿病足的主流敷料,有各种剂型,包括泡沫状、胶冻态、液态、粉末态、膏态等等,生产的厂家的非常多,其中的质量良莠不齐,很难鉴别。
进一步的清创就到了骨骼,对于骨髓炎最彻底的治疗方法就是去除被细菌侵袭的骨,正常的骨骼一般是浅黄色,如果发白或者变黑,往往就提示这段骨头可能活性比较差,另外,还有一种是面积比较大的骨暴露,一般的肉芽组织很难爬上去,因此,对于坏死的骨头及较大面积的骨暴露,一般需要清除。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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