Bogdan Păcularu-Burada 1,2 , Alexandru-Ionut, Cîrîc 3,* and Mihaela Begea 3
1 ICA Research & Development S.R.L., 202 Splaiul Independent,ei, 060021 Bucharest, Romania; bogdan.pacularu@ica-rd.ro
2 Dan Voiculescu Foundation for the Development of Romania, 011885 Bucharest, Romania
3 Faculty of Biotechnical Systems Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independent,ei, 060042 Bucharest, Romania; mihaela.begea@upb.ro
* Correspondence: alexandru.ciric@upb.ro
Citation: Păcularu-Burada, B.; Cîrîc, A.-I.; Begea, M. Anti-Aging Effects of Flavonoids from Plant Extracts. Foods
2024, 13, 2441. https://doi.org/ 10.3390/foods13152441
Academic Editor: Barry Parsons
Received: 4 July 2024
Revised: 25 July 2024
Accepted: 29 July 2024
Published: 2 August 2024
Copyright: © 2024 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Abstract: Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues’ and cells’ morphology and functionality and consequently being responsible for aging-related diseases. Taking into account the actual preoccupations of both consumers and researchers, healthy anti-aging alternatives are being intensively studied in order to address such concerns. Due to their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights the possibilities to use flavonoids extracted from various plants for their antiaging potential on the skin, brain, and heart. Moreover, their anticarcinogenic, anti-inflammatory, and anti-diabetic properties are summarized, along with the senescence-associated mechanisms. Both the nutraceutical and cosmeceutical fields are continuously developing and flavonoids originating from plants are promising candidates to obtain such products. Thus, the bioactive compounds’ extraction and their subsequent involvement in innovative product manufacturing must be carefully performed while being aware of the various intrinsic and extrinsic factors that may affect the phytochemicals’ structures, bioavailability, and health effects.
Keywords: flavonoids; senescence; diseases; anti-aging; nutraceuticals
Seongsu Kang 1 , Jiwon Park 1 , Zhihong Cheng 2 , Sanghyun Ye 1 , Seung-Hyun Jun 1,* and Nae-Gyu Kang 1,*
1 LG Household and Health Care R&D Center, Seoul 07795, Republic of Korea; franck.kang@lghnh.com (S.K.); jwon1222@lghnh.com (J.P.); shye123@lghnh.com (S.Y.)
2 Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, China; chengzhh@fudan.edu.cn
* Correspondence: junsh@lghnh.com (S.-H.J.); ngkang@lghnh.com (N.-G.K.); Tel.: +82-2-6980-1239 (S.-H.J.); +82-2-6980-1533 (N.-G.K.)
Citation: Kang, S.; Park, J.; Cheng, Z.; Ye, S.; Jun, S.-H.; Kang, N.-G. Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+ ) by Synergistic Inhibition of CD38 Expression. Cells 2024, 13, 1799.
https://doi.org/10.3390/ cells13211799
Academic Editor: Paweł Kordowitzki
Received: 8 October 2024
Revised: 28 October 2024
Accepted: 28 October 2024
Published: 30 October 2024
Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Abstract: Nicotinamide adenine dinucleotide (NAD+ ) is indispensable for the regulation of biological metabolism. Previous studies have revealed its role in aging and degenerative diseases, while crucially showing that supplementation with NAD+ or its precursors could ameliorate or reverse the progression of aging. Despite extensive evidence for the role and action of NAD+ in aging, its pharmacological activity on the skin, or even its mechanism, has not been elucidated. In this study, we established a novel approach to effectively utilize NAD+ for skin anti-aging by enhancing the pharmacological efficacy of exogenous NAD+ using a phytochemical complex consisting of quercetin, and enoxolone through inhibition of CD38. Through the comprehensive in vitro experiments based on human fibroblasts, we observed that exogenous NAD+ could exert protective effects against both extrinsic aging induced by ultraviolet light exposure and intrinsic aging. Additionally, we found that its effects were significantly boosted by quercetin and enoxolone. In this in-depth study, we demonstrated that these beneficial effects are mediated by improved sirtuin activation, autophagy, and mitochondrial functionality. Our approach is expected to verify the applicability of the topical application of NAD+ and offer more effective solutions for the unmet needs of patients and consumers who demand more effective anti-aging effects.
Keywords: nicotinamide adenine dinucleotide (NAD+ ); quercetin; enoxolone; anti-aging; topical application; CD38
原创: 十六点五 中山二院糖尿病足中心
我们今天(2018年11月6日)打开了患者的负压,希望能够有我们想要的结果
赖伯,2018年81岁,糖尿病史多年,2016年不幸伤到右足,经过几家医院反复转运,来到我院,期间发生“中风”、“消化道出血”、“心衰”等多种并发症,多次抢救之后,终于病情稳定,并在我院进行创面处理之后,达到下图的水平。
梁某,女,60岁,糖尿病病史7年,平时不规则用药,血糖控制一般。10余天前不小心刺伤左脚第2趾,到当地医院看病,感染扩散,当地医院建议截肢,患者要求转院于2018年10月27日转入我院。
截肢与保肢只差一个中山二院的距离
原创: 血管工程师 血管工程师
胡奶奶今年73岁高龄,10年前发现糖尿病,血糖一直控制不佳,还有高血压等疾病,3年前因右下肢静脉曲张在当地医院做过手术。1月前因左下肢无力、麻木,当地医院考虑为左下肢静脉曲张再次入院行左下肢静脉曲张手术。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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