yatulloh Alquraisy1 , Gofarana Wilar 2 , Ahmed Fouad Abdelwahab Mohammed3 , Ali El-Rayyes4 , Cecep Suhandi 1, Nasrul Wathoni 1
1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Padjadjaran, Sumedang, 45363, Indonesia;
2 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Padjadjaran, Sumedang, 45363, Indonesia; 3 Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt; 4 Department of Chemistry, College of Science, Northern Border University, Arar, Saudi Arabia
Correspondence: Nasrul Wathoni, Email 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Abstract: Various studies have been widely conducted on conditioned medium for the development of anti-aging preparations, including the utilization of stem cells, which present a promising alternative solution. This narrative review aims to understand the latest developments in various conditioned medium stem cell applications for anti-aging on the skin. A search of the Scopus database yielded publications of interest. The research focused on articles published without restrictions on the year. After finding 68 articles in the search results, they moved on to the checking phase. Upon comprehensive literature review, 23 articles met the inclusion criteria, while 45 articles were deemed ineligible for participation in this research. The results of the review indicate that conditioned medium from various stem cells has demonstrated success in reducing risk factors for skin aging, as proven in various tests. The successful reduction of the risk of skin aging has been established in vitro, in vivo, and in clinical trials. Given the numerous studies on the progress of exploring and utilizing conditioned medium, it is expected to provide a solution to the problem of skin aging.
Keywords: conditioned medium, stem cell, anti-aging, skin aging
Hana Yamamoto, Nanami Shimomura and Yasushi Hasegawa
College of Environmental Technology, Muroran Institute of Technology, 27-1 Mizumoto, Muroran 050-8585, Japan; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (H.Y.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (N.S.)
* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。; Tel.: +81-143-46-5745
Abstract: Pearl oysters have been extensively utilized in pearl production; however, most pearl oyster shells are discarded as industrial waste. In a previous study, we demonstrated that the intraperitoneal administration of pearl oyster shell-derived nacre extract (NE) prevented d-galactose-induced brain and skin aging. In this study, we examined the anti-aging effects of orally administered NE in senescence-accelerated mice (SAMP8). Feeding SAMP8 mice NE prevented the development of aging-related characteristics, such as coarse and dull hair, which are commonly observed in aged mice. Additionally, the NE mitigated muscle aging in SAMP8 mice, such as a decline in grip strength. Histological analysis of skeletal muscle revealed that the NE suppressed the expression of aging markers, cyclin-dependent kinase inhibitor 2A (p16) and cyclin-dependent kinase inhibitor 1 (p21), and increased the expression of sirtuin1 and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1)- α, which are involved in muscle synthesis. These findings suggest that the oral administration of NE suppresses skeletal muscle aging. Moreover, NE administration suppressed skin aging, including a decline in water content. Interestingly, oral administration of NE significantly extended the lifespan of SAMP8 mice, suggesting that its effectiveness as an anti-aging agent of various tissues including skeletal muscle, skin, and adipose tissue.
Keywords: skeletal muscle aging; nacre extract; lifespan extension; sarcopenia; skin aging
Citation: Yamamoto, H.; Shimomura,
N.; Hasegawa, Y. Oral Administration
of Nacre Extract from Pearl Oyster
Shells Has Anti-Aging Effects on Skin
and Muscle, and Extends the Lifespan
in SAMP8 Mice. Pharmaceuticals 2024,
17, 713. https://doi.org/
10.3390/ph17060713
Academic Editors: Mariia Shanaida,
Geir Bjørklund and Olha
Mykhailenko
Received: 16 May 2024
Revised: 28 May 2024
Accepted: 29 May 2024
Published: 31 May 2024
原创:十六点五 中山二院糖尿病足中心
伤口愈合的理念一般分为干性愈合和湿性愈合。
传统干性愈合理念认为干性愈合是一般愈合的生理过程,伤口愈合需干燥环境,需要氧气的作用。但事实上人类对氧气的利用需血红蛋白的氧和作用,而大气氧是不能直接被伤口所利用的。
原创:十六点五 中山二院糖尿病足中心
糖尿病足中有一种类型令人十分头疼,就是老人、干性坏疽、十分疼痛(静息疼痛,每到晚上患者都痛得喊“妈”),其实这种病人就是由于糖尿病外周血管病变为主要病因导致的糖尿病足。
糖尿病足是一种顽症,讲到底就是糖尿病人足部伤口难以愈合,而一般皮肤溃疡的愈合都是疤痕愈合,疤痕愈合最重要的原料就是胶原蛋白,因此,糖尿病足难以愈合最重要的直接原因就是在糖尿病的状态下,足部皮肤溃疡的胶原蛋白生成少、慢、质量差。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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