Rui Dias-Costa 1,* , Concepción Medrano-Padial 2 , Raquel Fernandes 1 , Raúl Domínguez-Perles 2 , Irene Gouvinhas 1 and Ana Novo Barros 1,*
1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes e Alto Douro, Quinta de Prados, 5000-801 Vila Real, Portugal; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.F.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (I.G.)
2 Laboratorio de Fitoquímica y Alimentos Saludables (LabFAS), Centro de Edafología y Biología Aplicada del Segura-Spanish Council for Scientific Research (EBAS-CSIC), University Campus of Espinardo 25, 30100 Murcia, Spain; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (C.M.-P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.D.-P.)
* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (R.D.-C.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.N.B.)
Citation: Dias-Costa, R.; MedranoPadial, C.; Fernandes, R.; DomínguezPerles, R.; Gouvinhas, I.; Barros, A.N. Valorisation of Winery By-Products: Revealing the Polyphenolic Profile of Grape Stems and Their Inhibitory Effects on Skin Aging-Enzymes for Cosmetic and Pharmaceutical Applications. Molecules 2024, 29, 5437.
https://doi.org/10.3390/molecules 29225437
Academic Editor: Michael Jourdes
Received: 17 October 2024
Revised: 9 November 2024
Accepted: 15 November 2024
Published: 18 November 2024
Copyright: © 2024 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Abstract: Grape (Vitis vinifera L.) stems, a by-product of winemaking, possess significant potential value due to their rich polyphenolic composition, which allows their exploitation for cosmetic and pharmaceutical applications. This presents a promising opportunity for valorisation aimed at developing innovative products with potential health-promoting effects. In this study, the polyphenolic profile of extracts from grape stems of seven white grape varieties was determined using spectrophotometric and chromatographic methods, specifically high-performance liquid chromatography coupled with a photodiode array detector and electrospray ionization multi-stage mass spectrometry (HPLCPDA-ESI-MSn), as well as on their ferric-reducing antioxidant power (FRAP) and radical scavenging capacity, using 2,2-diphenyl-1-picrylhydrazyl (DPPH• ) and 2,2′ -azino-bis(3-ethylbenzothiazoline-6- sulfonic acid (ABTS•+ ) radicals. This study also evaluated the anti-aging activity and skin depigmenting activity of these extracts. These findings revealed a diverse polyphenolic profile, encompassing proanthocyanidins and catechin derivatives (PCDs), phenolic acids, and flavonols. Among the varieties studied, ‘Códega do Larinho’ exhibited the highest concentrations of six distinct polyphenols and the highest total phenolic content. It also demonstrated the highest results for antioxidant capacity and elastase and tyrosinase inhibition. Pearson’s correlation analysis showed a significant positive correlation between certain PCDs with both FRAP and DPPH assays, as well as between the identified flavonols and anti-elastase activity. These results underscore the potential health benefits of grape stem extracts and emphasize the importance of their polyphenolic composition in enhancing antioxidant and anti-aging properties, thus supporting their application in different industries.
Keywords: grape stems; polyphenolic profile; antioxidant capacity; anti-aging; valorisation
Yu-Dan Wang 1 , Lu-Sheng Han 1 , Gen-Yue Li 1 , Kai-Li Yang 1 , Yan-Long Shen 2 , Hao Zhang 3 , Jian-Feng Hou 4 and En-Peng Wang 1,*
1 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.-D.W.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (L.-S.H.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (G.-Y.L.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (K.-L.Y.)
2 College of Innovation and Entrepreneurship, Changchun University of Chinese Medicine, Changchun 130117, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
3 Institute of Special Animal and Plant Sciences CAAS, Changchun 130112, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
4 Shiqi Biological R&D Centre (Suzhou Industrial Park) Co., Ltd., Suzhou 215125, China; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 * Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Citation: Wang, Y.-D.; Han, L.-S.; Li, G.-Y.; Yang, K.-L.; Shen, Y.-L.; Zhang, H.; Hou, J.-F.; Wang, E.-P. A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries. Molecules 2024, 29, 4962. https:// doi.org/ 10.3390/molecules29204962
Academic Editors: Jurca Tünde and
Laura Gratiela Vicas
Received: 5 September 2024
Revised: 14 October 2024
Accepted: 18 October 2024
Published: 20 October 2024
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
Abstract: This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultrahigh-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms. A total of 31 differential compounds, including saponins, flavonoids, phenolic acids, and other chemical constituents, were identified between the two groups. Superoxide dismutase (SOD) activity was more significantly increased (p < 0.05) and malondialdehyde (MDA) content was more significantly decreased (p < 0.01) in RGB more than YGB induced by UVB ultraviolet radiation. In terms of whitening effects, YGB was more effective in inhibiting the melanin content of B16-F10 cells (p < 0.01). The results of zebrafish experiments were consistent with those of in vitro experiments and cell biology experiments. The DCFH fluorescence staining results revealed that both ginseng berries were able to significantly reduce the level of reactive oxygen species (ROS) in zebrafish (p < 0.01). Comparison of chemical composition and skin care activities based on RGB and YGB can provide a theoretical basis for the deep development and utilization of ginseng berry resources.
Keywords: ginseng; ginseng berry; chemical composition; anti-aging; anti-UVB; anti-melanin; whitening
作者丨静雨轩 雷小航
夏季是许多“疤痕”人群最怕过的季节，一方面夏季衣着较少，有些疤痕部位裸露在外，影响美观，另一方面夏季高温，出汗多，也会刺激疤痕部位，痒、痛难耐。
原创： 胃肠肛肠疝外科 南充市中心医院
大肠癌是临床上最为常见的恶性肿瘤之一。根据全球癌症研究报告显示，2018年我国大肠癌新发病例超过25万人，跃居国内肿瘤发病率前5位。
Authors
Jeanette Fingren
Elisabet Lindholm
伤口世界平台生态圈，以“关爱人间所有伤口患者”为愿景，连接、整合和拓展线上和线下的管理慢性伤口的资源，倡导远程、就近和居家管理慢性伤口，解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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