Magdalena Wójciak 1,* , Piotr Drozdowski 2,* , Agnieszka Skalska-Kami ´nska 1 , Martyna Zagórska-Dziok 3 , Aleksandra Ziemlewska 3 , Zofia Nizioł-Łukaszewska 3 and Małgorzata Latalska 4
1 Department of Analytical Chemistry, Medical University of Lublin, Chod´zki 4a, 20-093 Lublin, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
2 Department of Plastic Surgery, Specialist Medical Centre, 57-320 Polanica-Zdrój, Poland
3 Department of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.Z.-D.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (A.Z.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Z.N.-Ł.)
4 Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-079 Lublin, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (M.W.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (P.D.)
Citation: Wójciak, M.; Drozdowski, P.; Skalska-Kami ´nska, A.; Zagórska Dziok, M.; Ziemlewska, A.; Nizioł- Łukaszewska, Z.; Latalska, M. Protective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies. Molecules 2024, 29, 5790. https://doi.org/10.3390/ molecules29235790
Academic Editors: José Basilio Heredia, Luis Angel CabanillasBojórquez and Marilyn
Shomara Criollo-Mendoza
Received: 1 November 2024
Revised: 1 December 2024
Accepted: 5 December 2024
Published: 7 December 2024
Abstract: Isoflavones are found in numerous plant species within the Leguminosae family; however, soy isoflavones are particularly significant in practice and have been extensively studied in recent years. The health-promoting potential of orally administered soy isoflavones is widely documented in the scientific literature, and many review articles have been developed to highlight their significance. However, it should be noted that soy-isoflavone-rich extracts and isolated soy isoflavones, such as genistein and daidzein, are also often applied topically as ingredients in many formulations, including face creams, tonics, and emulsions. New delivery systems are continuously being developed to enhance the skin permeability of isoflavones, thus improving their efficacy. In this context, their direct activity on skin cells is an important aspect of scientific research. The anti-inflammatory, protective, and antioxidant properties of isoflavones and soy extracts make them promising cosmetic ingredients with anti-aging potential because inflammation and the accumulation of reactive oxygen species (ROS) can lead to structural and functional changes in skin cells, accelerating the aging process. This review provides an overview of research on the impact of the application of soy isoflavone extract and soy-derived isoflavones on skin cells, with a focus on the documented molecular mechanisms underlying their effects. This study aims to offer essential insights to aid in the development of functional cosmetics and future clinical applications.
Keywords: phytoestrogens; topical application; genistein; daidzein; fibroblasts; keratinocytes; skin
Minseo Kang 1,† , Somin Park 2,†, So-Ri Son 2 , Yedam Noh 2 , Dae Sik Jang 2,* and Sullim Lee 1,*
1 Department of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
2 Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.P.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.-R.S.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (Y.N.)
* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (D.S.J.); 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。 (S.L.)
† These authors equally contributed to this work.
Abstract: Panax ginseng (Korean ginseng) is renowned for its health-promoting properties, attributed to its bioactive compounds, including saponins, polyphenols, and polysaccharides, which possess both antioxidant and anti-aging activities. This study investigated the anti-aging and antiinflammatory effects of compounds isolated from the hot water extract of fresh P. ginseng roots, evaluating their resistance to TNF-α/IFN-γ-induced skin cell damage. Among 14 compounds, ginsenoside Rf (compound 2) showed significant multi-target effects. In NHDFs, ginsenoside Rf and others effectively reduced intracellular ROS, demonstrating strong antioxidant properties. Additionally, they inhibited MMP-1 expression, a key enzyme in collagen degradation, and promoted pro-collagen Type I synthesis, countering the negative effects of TNF-α and supporting skin health. Further analysis showed that ginsenoside Rf reduced the secretion of inflammatory cytokines like IL-1β and IL-6, exhibiting anti-inflammatory effects. It also promoted the expression of crucial skin barrier proteins, including LOR, AQP3, FLG, and KRT1 in TNF-α/IFN-γ-stimulated NHEKs, enhancing skin hydration and structural integrity. These results suggest that compounds from P. ginseng roots, especially ginsenoside Rf, hold promise as skincare agents targeting skin aging and inflammation. Future research should further explore their mechanisms and optimize their applications in dermatological treatments.
Keywords: ginsenoside Rf; P. ginseng; anti-aging; anti-inflammatory; ROS; MMP-1; skin barrier; TNF-α/IFN-γ
Citation: Kang, M.; Park, S.; Son, S.-R.; Noh, Y.; Jang, D.S.; Lee, S. Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ- Induced Skin Cell Damage. Molecules 2024, 29, 5479. https://doi.org/ 10.3390/molecules29225479
Academic Editor: Enrique
Barrajón-Catalán
Received: 24 October 2024
Revised: 15 November 2024
Accepted: 18 November 2024
Published: 20 November 2024
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不小心受伤了，经过医生缝合后，回到了家里，许多人最关心的问题是：伤口为什么要缝合？我该怎么来护理伤口？怎么样才能避免伤口感染？怎么样让伤口长得更好？什么时候才能拆线？怎么样才能够使得我的伤口疤痕最小？今天，我来回答这个问题。
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