CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice

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19 9月 2025

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Author : 伤口世界

CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice

This article is excerpted from the 《Aging Cell》 by Wound World

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Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial
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Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency 2026-07-29 00:00

Serhan Sakarya, MD¹ ; Necati Gunay, MS²; Meltem Karakulak, MS³ ; Barcin Ozturk, MD¹; Bulent Ertugrul, MD¹

Abstract: Introduction. Chronic wounds and the infections associated with them are responsible for a considerable escalation in morbidity and the cost of health care. Infection and cellular activation and the relation between cells are 2 critical factors in wound healing. Since chronic wounds offer ideal conditions for infection and biofilm production, good wound care strategies are critical for wound healing. Topical antiseptics in chronic wounds remain in widespread use today. These antiseptics are successful in microbial eradication, but their cytotoxcity is a controversial issue in wound healing. Objective. The aim of this study was to investigate the effect of stabilized hypochlorous acid solution (HOCl) on killing rate, biofilm formation, antimicrobial activity within biofilm against frequently isolated microorganisms and migration rate of wounded fibroblasts and keratinocytes. Materials and Methods. Minimal bactericidal concentration of stabilized HOCl solution for all standard microorganisms was 1/64 dilution and for clinical isolates it ranged from 1/32 to 1/64 dilutions Results. All microorganisms were killed within 0 minutes and accurate killing time was 12 seconds. The effective dose for biofilm impairment for standard microorganisms and clinical isolates ranged from 1/32 to 1/16. Microbicidal effects within the biofilm and antibiofilm concentration was the same for each microorganism. Conclusion. The stabilized HOCl solution had dose-dependent favorable effects on fibroblast and keratinocyte migration compared to povidone iodine and media alone. These features lead to a stabilized HOCl solution as an ideal wound care agent.

Key words: hypochlorous acid, biofilm, wound healing, fibroblast, keratinocyte
Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial 2026-07-28 00:00

Azadeh Dorostkar¹ , Mehdi Ghahartars¹ , Mohammadreza Namazi¹ , Nafiseh Todarbary² , Maryam Hadibarhaghtalab¹ , Maryam Rezaee¹

1 Dermatology Department, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Key words: topical, sodium hypochlorite, acne vulgaris, treatment

Citation: Dorostkar A, Ghahartars M, Namazi M, Todarbary N, Hadibarhaghtalab M, Rezaee M. Sodium hypochlorite 0.005%

versus placebo in the treatment of mild to moderate acne: a double-blind randomized controlled trial. Dermatol Pract Concept.

2021;11(3):e2021046. DOI: https://doi.org/10.5826/dpc.1103a46

Accepted: December 9, 2020; Published: May 20, 2021

Copyright: ©2021 Dorostkar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License

BY-NC-4.0, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors

and source are credited.

Competing interests: The authors have no conflicts of interest to declare.

Funding: None

Corresponding author: Maryam Hadibarhaghtalab, Department of Dermatology, Faghihi Hospital, Zand Street, Shiraz, Iran.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

ABSTRACT

Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions.

Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions.

Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation.

Results: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month.

Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones.

Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1.
Sodium Hypochlorite 0.005% Versus Placebo in the Treatment of Mild to Moderate Acne: A Double-Blind Randomized Controlled Trial 2026-07-28 00:00

Azadeh Dorostkar¹ , Mehdi Ghahartars¹ , Mohammadreza Namazi¹ , Nafiseh Todarbary² , Maryam Hadibarhaghtalab¹ , Maryam Rezaee¹

1 Dermatology Department, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

Key words: topical, sodium hypochlorite, acne vulgaris, treatment

Citation: Dorostkar A, Ghahartars M, Namazi M, Todarbary N, Hadibarhaghtalab M, Rezaee M. Sodium hypochlorite 0.005%

versus placebo in the treatment of mild to moderate acne: a double-blind randomized controlled trial. Dermatol Pract Concept.

2021;11(3):e2021046. DOI: https://doi.org/10.5826/dpc.1103a46

Accepted: December 9, 2020; Published: May 20, 2021

Copyright: ©2021 Dorostkar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License

BY-NC-4.0, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original authors

and source are credited.

Competing interests: The authors have no conflicts of interest to declare.

Funding: None

Corresponding author: Maryam Hadibarhaghtalab, Department of Dermatology, Faghihi Hospital, Zand Street, Shiraz, Iran.

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

ABSTRACT

Background: Acne vulgaris is a common inflammatory disease of the pilosebaceous follicle that affects many teenagers and young people. There is an obvious need for topical treatments with good tolerability and efficacy for the management of acne lesions.

Objective: This study determined the therapeutic efficacy of topical sodium hypochlorite solution (0.005%) in the treatment of mild to moderate acne lesions.

Methods: This placebo-controlled randomized controlled trial compared 0.005% sodium hypochlorite to placebo administered topically on each side of the patients’ faces 3 times a day for 1 month. The numbers of papules and pustules were recorded at baseline, 1, 2 and 4 weeks after initiation.

Results: The total number of papules and pustules decreased after topical application of sodium hypochlorite 0.005% for 1 month.

Conclusions: Topical sodium hypochlorite solution (0.005%) can be effective in the treatment of mild to moderate acne, and its clinical efficacy was evaluated between the male and female groups and between the hormonal and non-hormonal ones.

Trial registration: Our study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code number IRCT20200701047976N1.

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice

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主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice

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