Bogdan Păcularu-Burada 1,2 , Alexandru-Ionut, Cîrîc 3,* and Mihaela Begea 3

1 ICA Research & Development S.R.L., 202 Splaiul Independent,ei, 060021 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

2 Dan Voiculescu Foundation for the Development of Romania, 011885 Bucharest, Romania

3 Faculty of Biotechnical Systems Engineering, National University of Science and Technology Politehnica Bucharest, 313 Splaiul Independent,ei, 060042 Bucharest, Romania; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Citation: Păcularu-Burada, B.; Cîrîc, A.-I.; Begea, M. Anti-Aging Effects of Flavonoids from Plant Extracts. Foods

2024, 13, 2441. https://doi.org/ 10.3390/foods13152441

Academic Editor: Barry Parsons

Received: 4 July 2024

Revised: 25 July 2024

Accepted: 29 July 2024

Published: 2 August 2024

Copyright: © 2024 by the authors.

Licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Abstract: Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues’ and cells’ morphology and functionality and consequently being responsible for aging-related diseases. Taking into account the actual preoccupations of both consumers and researchers, healthy anti-aging alternatives are being intensively studied in order to address such concerns. Due to their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights the possibilities to use flavonoids extracted from various plants for their antiaging potential on the skin, brain, and heart. Moreover, their anticarcinogenic, anti-inflammatory, and anti-diabetic properties are summarized, along with the senescence-associated mechanisms. Both the nutraceutical and cosmeceutical fields are continuously developing and flavonoids originating from plants are promising candidates to obtain such products. Thus, the bioactive compounds’ extraction and their subsequent involvement in innovative product manufacturing must be carefully performed while being aware of the various intrinsic and extrinsic factors that may affect the phytochemicals’ structures, bioavailability, and health effects.

Keywords: flavonoids; senescence; diseases; anti-aging; nutraceuticals