皮肤屏障功能维持着机体内环境稳定[1]。遗传基因异常、生理性衰退及各种疾病等均可破坏皮肤完整性,导致屏障功能障碍,进一步影响皮肤健康乃至疾病的发生和发展[2]。因此,使用保湿润肤类产品成为保护和修复皮肤屏障的重要措施。为规范及合理应用保湿润肤类产品,中国医师协会皮肤科医师分会组织国内有关专家,结合国内外研究现状,就保湿润肤类产品的功效、成分选择、应用指征、使用方法、不良反应及注意事项等深入讨论并达成应用指导的专家共识。
为减少不良反应,产品配方应简单温和,少用或者不用香精、着色剂、防腐剂及表面活性剂等添加剂[58]。对有化妆品过敏史或过敏体质的人群,可选择化妆品系列抗原做斑贴试验,以明确致敏成分,在使用前须查阅产品配方,规避相关成分,避免化妆品接触性皮炎的发生[59]。对于婴幼儿(尤其患有板层状鱼鳞病、烧伤等疾病时),需要避免使用含有丙二醇、水杨酸以及高浓度尿素的保湿润肤类产品,以免导致相关成分经表皮吸收后引起的系统毒性反应[4,55]。
应用保湿润肤类产品是维持和修护皮肤屏障、保证皮肤健康的重要措施。本共识结合国内外研究现状,就保湿润肤类产品的功效、成分选择、应用指征、使用方法、不良反应及注意事项等进行深入讨论,希望能规范该类产品的使用。高等级研究证据的缺乏给本共识的制订带来很大挑战。希望未来能开展更高水平的研究工作,为修订本共识提供更多的证据。
范宇焜(重庆医科大学附属第三医院皮肤整形美容中心)、高兴华(中国医科大学附属第一医院)、耿松梅(西安交通大学第二附属医院皮肤科)、顾恒(中国医学科学院皮肤病医院)、郝飞(重庆医科大学附属第三医院皮肤整形美容中心)、蒋献(四川大学华西医院皮肤科)、刘喆(华熙生物科技股份有限公司)、王华(重庆医科大学附属儿童医院皮肤科)、吴艳(北京大学第一医院皮肤科)、项蕾红(复旦大学附属华山医院皮肤科)、杨斌(南方医科大学皮肤病医院)、袁超(同济大学附属皮肤病医院)、邹颖(同济大学附属皮肤病医院)
郝飞、吴艳、袁超、邹颖、刘喆、范宇焜
所有作者均声明无利益冲突
参 考 文 献
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