Maja Paterska 1 , Bogusław Czerny 2,3 and Judyta Cielecka-Piontek 4,*
1 Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznan, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
2 Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, 62-064 Plewiska, Poland; 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
3 Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland
4 Department of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland
* Correspondence: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Citation: Paterska, M.; Czerny, B.;
Cielecka-Piontek, J. Macrofungal
Extracts as a Source of Bioactive
Compounds for Cosmetical
Anti-Aging Therapy: A
Comprehensive Review. Nutrients
2024, 16, 2810. https://doi.org/
10.3390/nu16162810
Academic Editors: Arrigo Cicero and
Akiko Kojima-Yuasa
Received: 26 June 2024
Revised: 21 August 2024
Accepted: 22 August 2024
Published: 22 August 2024
Abstract: For centuries, mushrooms have been used as a component of skincare formulations. Environmental stresses and a modern lifestyle expose the skin to accelerated aging. To slow down this process, natural anti-aging skincare ingredients are being sought. In this review, 52 scientific publications about the effects of chemical compounds extracted from the fruiting bodies of macrofungi on skin cells were selected. The effects of extracts from nine species that are tested for anti-aging effects have been described. According to available literature data, macrofungi contain many polysaccharides, phenolic compounds, polysaccharide peptides, free amino acids, sterols, proteins, glycosides, triterpenes, alkaloids, which can have an anti-aging effect on the skin by acting as antioxidants, photoprotective, skin whitening, moisturizing, anti-inflammatory and stabilizing collagen, elastin and hyaluronic acid levels in the skin.
Keywords: anti-aging; Trametes versicolor; Schizophyllum commune; Tremella fuciformis; Pleurotus ostreatus; Agaricus subrufescens; Volvariella volvacea; Ganoderma lucidum; Letinula edodes; Inonotus obliquus; mushrooms; macrofungi
Suradwadee Thungmungmee1 , Boonchoo Sritularak2 , Nakuntwalai Wisidsri1 , Nattakan Kanana3 , Nattika Nimmano3
1 Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, Thailand;
2 Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Science, Chulalongkorn University, Bangkok, Thailand;
3 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
Correspondence: Nattika Nimmano, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Tel +66 0 2188399, Fax +66 0 2188401, Email 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
Purpose: The study aimed to investigate in vitro anti-aging activities of 29 Dendrobium spp. and develop and characterize microemulsions (MEs) for topical application.
Methods: Antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2 scavenging, and ferric reducing antioxidant power (FRAP) assays. The anti-collagenase (MMP-1 and MMP-2) and anti-elastase activities were also evaluated.
Cytotoxicity and human intracellular reactive oxygen species (ROS) levels were determined using resazurin reduction and 2′,7′- dichlorofluorescin diacetate (DCFDA) assays, respectively. D. kentrophyllum extract-loaded microemulsion (DKME) was then prepared and optimized. The stability of DKME was studied using a heating-cooling cycle.
Results: D. kentrophyllum appeared to be the best candidate anti-aging agent because of its antioxidant, anti-collagenase, and antielastase activities. The extract was safe for human skin cells at a concentration of 6.25–100 μg/mL. It also decreased the intracellular ROS-induced ultraviolet B (UVB) irradiation compared to that in the control. DKME comprising Tween 80:ethanol (5:1), water, and isononyl isononanoate showed a suitable appearance, droplet size, polydisperse index, zeta potential, pH, and viscosity. This formulation demonstrated desirable physical and chemical stability, with non-cytotoxic effects.
Conclusion: DKME is considered a promising anti-aging product. However, an in vivo study of this optimized formulation might be evaluated in further study for anti-aging purposes.
Keywords: reactive oxygen species, anti-aging activities, Dendrobium kentrophyllum, microemulsion
原创: 十六点五 中山二院糖尿病足中心
经过反复权衡掂量,以及与患者、患者家属沟通,决定对于患者生长比较好的右足采取“点状植皮”,以加速患者伤口愈合,减少伤口的渗出。在进行植皮之前,首先再次对伤口进行清创,尽可能清除可能影响植皮效果的组织,之后装负压(2019年1月24日),准备下周四(2019年1月31日)在手术台上拆负压,直接植皮,之后再装负压,以促进植皮的贴敷,增加植皮的成功率。
2019年1月22日,对患者的足进行了第一次清创,效果如下:
由于各种原因,患者到中心的合作医院治疗了整整两个星期。在不断的微信沟通下,合作医院的医生进行了不懈的努力,患者继续向保足的方向又前进了几步。
周末很快就过去了,今天才想办法将病人收入病房,这两天在病房护士的帮助下,进行安尔碘纱布填塞换药,借助急诊科的留观床进行内科治疗,控制血糖、全身抗生素、监测全身重要脏器功能、营养支持等,由于患者脓液被充分引流,局部炎症反应有所消除,患者全身炎症反应(SIRS)明显改善。
伤口世界平台生态圈,以“关爱人间所有伤口患者”为愿景,连接、整合和拓展线上和线下的管理慢性伤口的资源,倡导远程、就近和居家管理慢性伤口,解决伤口专家的碎片化时间的价值创造、诊疗经验的裂变复制、和患者的就近、居家和低成本管理慢性伤口的问题。
2019广东省医疗行业协会伤口管理分会年会
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