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蔡道章院长

Custom Mod Mega1

主任医师、教授、博导，南方医科大学第三附属医院（广东省骨科医院）院长

中德骨科伤口管理学校校长

广东省骨科研究院运动医学研究所所长

广东省内运动医学专业唯一的博士研究生导师

美国哈弗大学医学院骨科访问学者

专业特长处于省内领先、国内或国际先进水平以上

2018年获得“国之名医卓越建树”荣誉称号

2017年被评为全国卫生计生系统先进工作者、广东省医学领军人才

中国医师协会运动医师分会副会长

STCOT中国部运动医学分会副主任委员

广东省医学会关节外科分会主任委员

广东省医学会运动医学会分会名誉主任委员

独立承担过国家“863”课题，主持过10余项省、部级科研项目

多份专业杂志编委
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最新文献

Mitigating Glycation and Oxidative Stress in Aesthetic Medicine: Hyaluronic Acid and Trehalose Synergy for Anti-AGEs Action in Skin Aging Treatment 2025-04-29 00:00

Robert Chmielewski1–3 , Aleksandra Lesiak4,5

1 Prime Clinic, Warsaw, Poland;

2 Positive Pro-Aging Foundation, Warsaw, Poland;

3 URGO Aesthetics Department, URGO, Warsaw, Poland;

4 Dermoklinika Medical Center, Lodz, Poland; 5 Department of Dermatology, Pediatric Dermatology and Oncology, Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, Lodz, Poland Correspondence: Aleksandra Lesiak, Department of Dermatology, Pediatric Dermatology and Oncology, Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, 16 Pankiewicza Street, Lodz, Poland, 91-738, Email aleksandra.lesiak@umed.lodz.pl

Abstract: This comprehensive review explores the pivotal roles of glycation and oxidative stress in the aging process of the skin, their targeted therapeutic applications in aesthetic and regenerative medicine, as well as anti-aging interventions. Glycation, a biochemical process involving the non-enzymatic attachment of sugars to proteins, lipids, or nucleic acids, culminates in the formation of Advanced Glycation End products (AGEs). These AGEs are significant contributors to aging and various chronic ailments, triggering oxidative stress and inflammatory pathways, thereby manifesting as wrinkles, diminished skin elasticity, and other age-related dermal alterations. A central focus of this review is the synergistic interplay between Hyaluronic Acid (HA) and Trehalose in combating these aging mechanisms. HA, renowned for its anti-inflammatory and antioxidative properties, assumes a pivotal role in modulating Reactive Oxygen Species (ROS) levels and safeguarding against oxidative damage. Concurrently, trehalose targetsglycation and oxidative stress, exhibiting promising outcomes in augmenting skin health, providing Ultraviolet B (UVB) photoprotection, and manifesting notable anti-photoaging effects. The combined administration of HA and trehalose not only addresses existing skin damage but also confers preventive and reparative benefits, particularly in stabilizing HA and mitigating glycation-induced stress. Their synergistic action significantly enhances skin quality and mitigates inflammation. The implications of these findings are profound for the future of anti-aging therapeutics in aesthetic medicine, suggesting that the integration of HA and trehalose holds promise for revolutionary advancements in preserving skin vitality and health. Moreover this paper underscores the imperative for continued research into the combined efficacy of these compounds, advocating for innovative therapeutic modalities in aesthetic medicine and enhanced strategies for combating aging, glycation, and oxidative stress.

Keywords: hyaluronic acid, trehalose, skin aging, glycation, oxidative stress, anti-aging therapies

Collagen Type VII (COL7A1) as a Longevity Mediator in Caenorhabditis elegans: Anti-Aging Effects on Healthspan Extension and Skin Collagen Synthesis 2025-04-28 00:00

Juewon Kim1,

*, Hyeryung Kim2 , Woo-Young Seo3 , Eunji Lee3 and Donghyun Cho4

1 Department of Physiology, Konkuk University College of Medicine, Chungju 27478,

2 GENINUS Inc., Seoul 05836,

3 ABIOTECH Co., Ltd., Suwon 16675,

4 HEM pharma, Suwon 16229, Republic of Korea

Abstract

Longevity genes and senescence-related signaling proteins are crucial targets in aging research, which aims to enhance the healthy period and quality of life. Identifying these target proteins remains challenging because of the need for precise categorization and validation methods. Our multifaceted approach combined bioinformatics with transcriptomic data to identify collagen as a key element associated with the lifespan of the model organism, Caenorhabditis elegans. By analyzing transcriptomic data from long-lived mutants that involved mechanisms such as antioxidation, dietary restriction, and genetic background, we identified collagen as a common longevity-associated gene. We validated these findings by confirming that collagen peptides positively affect lifespan, thereby strengthening the validity of the target. Further verification through healthspan factors in C. elegans and functional assays in skin fibroblasts provided additional evidence of the role of collagen in organismal aging. Specifically, our study revealed that collagen type VII is a significant target protein for mitigating age-related decline. By validating these findings across different aging models and cell-based studies, we present compelling evidence for the anti-aging effects of collagen type VII, highlighting its potential as a target for promoting healthy aging. This study proposes that collagen not only serves as an indicative marker of organismal longevity across various senescence-related signaling pathways, but also offers a mechanistic understanding of skin degeneration. Consequently, collagen is an effective target for interventions aimed at mitigating skin aging. This study underscores the potential of collagen type VII (bonding collagen T7) as a therapeutic target for enhancing skin health and overall longevity.

Key Words: Collagen VII, Healthspan, C. elegans, Skin aging, Bonding collagen

https://doi.org/10.4062/biomolther.2024.127

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received Aug 1, 2024 Revised Sep 10, 2024 Accepted Sep 30, 2024

Published Online Oct 21, 2024

*

Corresponding Author

E-mail: juewon@kku.ac.kr

Tel: +82-43-840-3728, Fax: +82-2-2049-6195
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伤口世界

电子邮件地址: michael.kung@139.com

星期五, 20 9月 2019

抠痘痘，引发的一场惨案

负压引流与创面修复

文章转自公众号普外时间，作者胡海涛

抠痘痘，简单不？大家肯定都做过。而说到抠痘痘的危害，可能大多数人会想到颅内感染，抠位于面部危险三角区域的痘痘，确实容易导致颅内感染，造成严重问题。

7岁瘫痪女孩压疮3月，只因4年前爬出阳台……

星期五, 20 9月 2019

7岁瘫痪女孩压疮3月，只因4年前爬出阳台……

原创：胡海涛负压引流与创面修复

降温了，糖友们热水洗脚时，小心别被‘烫猪蹄儿’！

星期四, 19 9月 2019

降温了，糖友们热水洗脚时，小心别被‘烫猪蹄儿’！

原创：萤火虫医生负压引流与创面修复

冬天足浴，是一种享受，可以促进人体脚部血液循环，达到改善脚部经络，促进人体健康的目的。

星期四, 19 9月 2019

改良封闭式负压引流技术治疗腹部手术切口感染临床研究

原创：胡海涛负压引流与创面修复

谎言：使用胰岛素，会上瘾，导致终身依赖！

星期四, 19 9月 2019

谎言：使用胰岛素，会上瘾，导致终身依赖！

负压引流与创面修复

文章转载自公众号资讯，作者胡海涛

很多糖尿病患者听说要注射胰岛第一反应就是拒绝。

星期四, 19 9月 2019

认识成人脐炎的真相，否则天天换药也很难愈合！

原创：胡海涛负压引流与创面修复

患者性别：男
患者年龄：32岁
简要病史：反复肚脐流脓1年，保守治疗无效。
体格检查：肚脐部稍红肿，中间破溃渗液，有脓性分泌物，压痛。

学术会议

2019广东省医疗行业协会伤口管理分会年会

扫一扫了解详情:

2019年6月15日中国广州
主办单位：广东省医疗行业协会伤口管理分会

伤口世界提示

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