
伤口世界

- 星期四, 03 4月 2025
Betaine–salicylic acid cocrystal for enhanced skincare and acne treatment†
Zhenyuan Wang,ab Mi Wang, *a Qingsheng Tao,c Yufei Li, d Hao Wang,a Mei Zhang,c Xueli Liuc and Jiaheng Zhang *a
a Sauvage Laboratory for Smart Materials, School of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China. E-mail: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。, 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。
b Shenzhen Shinehigh Innovation Technology Co., Ltd., Shenzhen 518055, China
c Advanced Research, L'Oreal Research & Innovation China, Shanghai 201206, China
d The Centre in Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao 999078, China
† Electronic supplementary information (ESI) available. CCDC 2101906. For ESI
and crystallographic data in CIF or other electronic format see DOI: https://doi.
org/10.1039/d5md00001g
Salicylic acid (SA) is a natural lipophilic active ingredient commonly used in cosmetics and skin disease treatments, offering benefits such as exfoliation, anti-inflammation effects, antibacterial properties, oil control, and acne alleviation. However, its poor water solubility, low bioavailability, and potential side effects, such as allergies, irritation, and dryness, hinder its widespread application. In this study, we prepared a betaine–salicylic acid (BeSA) cocrystal and systematically characterized its crystal structure, biological activity, and clinical efficacy. The results showed that BeSA has significantly lower irritancy and cytotoxicity than SA, but exhibits excellent anti-inflammatory and antioxidant properties as well as high moisturizing and anti-acne efficacy, making it a potential alternative to SA. Further, quantum chemical calculations and molecular docking simulations were conducted to investigate the intrinsic mechanisms underlying the excellent bioactivity of BeSA cocrystals. This study introduces an innovative solution for safer and more effective skincare formulations based on SA and offers theoretical guidance regarding material engineering and further material optimization, which has crucial implications for both industry and academia.
Received 1st January 2025,
Accepted 4th February 2025
DOI: 10.1039/d5md00001g rsc.li/medchem

- 星期三, 02 4月 2025
Treatment effects of two pharmaceutical skin care creams for xerotic feet among persons with diabetes: Rationale and design of a two-armed double blind randomized controlled trial
Anna Ericsson a,* , Karin Borgstrom¨ b,c , Christine Kumlien a,c,d , Magdalena Gershater Annersten a,c , Tautgirdas Ruzgas b,c , Johan Engblom b,c , Petri Gudmundsson b,c , Victoria Lazer a , Skaidre Jankovskaja b,c , Eva Lavant b,c , Sophia Ågren-Witteschus d , Sebastian Bjorklund ¨ b,d , Saman Salim e,f , Mikael Åstrom¨ g , Stefan Acosta f
a Department of Care Science, Faculty of Health and Society, Malm¨ o University, Malm¨ o, Sweden
b Department of Biomedical Science, Faculty of Health and Society, Malm¨ o University, Malm¨ o, Sweden
c Biofilms – Research Center for Biointerfaces, Malm¨ o University, Malm¨ o, Sweden
d Department of Cardiothoracic and Vascular Surgery, Skåne University Hospital, Malm¨ o, Sweden
e Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark
f Department of Clinical Sciences, Lund University, Malmo, ¨ Sweden
g StatCons, Sweden
ARTICLE INFO
Keywords: Diabetes mellitus Dry feet Prevention Foot-xerosis Self-care
ABSTRACT
Introduction: To minimize the risk of developing foot-ulcers, persons with diabetes are given the advice to daily inspect their feet and to apply skincare formulations. However, commercially available skincare products have rarely been developed and evaluated for diabetes foot care specifically. The primary aim of this randomized controlled trial (RCT) is to evaluate the effects in reducing foot xerosis in persons with diabetes without footulcers using two skincare creams containing different humectants (interventions) against a cream base nonhumectant (comparator). Secondary outcomes are to evaluate differences on skin barrier integrity, lowmolecular weight biomarkers and skin microbiota, microcirculation including transcutaneous oxygen pressure, degree of neuropathy, and HbA1c between intervention-comparator creams.
Methods: Two-armed double-blind RCT, registered in ClinicalTrials.gov Identifier: NCT06427889. With 80 % power, two-tailed significance of 2.5 % in each arm, 39 study persons is needed in each arm, total 78 persons, 98 including dropouts, to be able to prove a reduction of at least one category in the Xerosis Severity Scale with the intervention creams compared to the comparator. In one arm, each participant will treat one foot with one of the intervention creams (Oviderm® or Canoderm®), while the opposite foot will be treated with the comparator cream (Decubal®lipid cream), twice a day. If needed, participants are enrolled after a wash-out period of two weeks. The participants will undergo examinations at baseline, day 14 and day 28.
Discussion: This RCT evaluate the potential effects of humectants in skin creams against foot xerosis in persons with diabetes.

- 星期二, 01 4月 2025
Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles
Ha Young Park a , Min Ho Kang a , Guewha Lee b , Jin Woo Kim a,c,*
a Department of Food Science, Sunmoon University, Chungcheongnam-do, Republic of Korea
b Hu evergreen Pharm Inc., Incheon, Republic of Korea
c Center for Next-Generation Semiconductor Technology, Sun Moon University, Chungnam, Republic of Korea
ARTICLE INFO
Keywords: Ginseng non-edible callus Extracellular vesicle Skin regeneration Collagen synthesis Proliferation
1 . ABSTRACT
Background: This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF).
Methods: GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis (TGF-β, SMAD-2, SMAD-3, COL1A1) was measured using RT-PCR.
Results: Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically TGF-β, SMAD-2, SMAD-3, and COL1A1, by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the TGF-β/SMAD signaling pathway, showcasing its potential to induce skin
Conclusions: In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the TGF-β/SMAD signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology

- 星期一, 31 3月 2025
Leveraging Single Nucleotide Polymorphism Profiling for Precision Skin Care: How SNPs Shape Individual Responses in Cosmetic Dermatology
Diala Haykal
Centre Médical Laser Palaiseau, Palaiseau, France
Correspondence: Diala Haykal (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)
Received: 5 December 2024 | Accepted: 15 December 2024
Funding: The author received no specific funding for this work.
Keywords: cosmetic dermatology | genetic predisposition | personalized skincare | precision medicine | single nucleotide polymorphisms (SNPs) profiling

- 星期五, 28 3月 2025
Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin
Liang Chen1,2 | Fudi Wang3 | Xiaoyun Hu1,2 | Nihong Li1,2 | Ying Gao4 | Fengfeng Xue5 | Ling Xie1,2 | Min Xie1,2
1 Scientific Research Laboratory, Shanghai Le-Surely Biotechnology Co. Ltd, Shanghai, China |
2 SASELOMO Research Institute and Biological Laboratory, Shanghai Chuanmei Industrial Co. Ltd, Shanghai, China |
3 Evelab Insight (Singapore) Pte. Ltd, Singapore, Singapore |
4 Zhejiang Moda Biotech Co. Ltd, Hangzhou, China |
5 Nanomedicine and Intestinal Microecology Research Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China
Correspondence: Liang Chen (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。) | Fengfeng Xue (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)
Received: 5 September 2024 | Revised: 25 December 2024 | Accepted: 24 January 2025
Funding: The authors received no specific funding for this work.
Keywords: antiaging | baicalin | bio-vesicle | skin physiology and cell culture | transdermal delivery

- 星期四, 27 3月 2025
Preparation and Evaluation of Complexed Ubiquinone (Coenzyme Q10) Antiaging Hyaluronic Acid–Vitamin C Serum for Skin Care
Hawazin Arkan Yousif1 | Israa Al-Ani1 | Maha N. Abu Hajleh2 | Sina Matalqah1 | Wael Abu Dayyih3 |
Emad A. Al-Dujaili4
1 Department of Pharmaceutics and Pharmaceutical Technology, Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya
Amman University, Amman, Jordan |
2 Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical
Sciences, Al-Ahliyya Amman University, Amman, Jordan |
3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mutah University, Al-Karak,
Jordan |
4 Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
Correspondence: Maha N. Abu Hajleh (该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。)
Received: 26 August 2024 | Revised: 4 October 2024 | Accepted: 18 November 2024
Keywords: antiaging | coenzyme Q10 | hyaluronic acid | skin care | ubiquinone